Human Gene TMEM158 (ENST00000503771.2_6) from GENCODE V48lift37
  Description: transmembrane protein 158 (from RefSeq NM_015444.3)
Gencode Transcript: ENST00000503771.2_6
Gencode Gene: ENSG00000249992.2_8
Transcript (Including UTRs)
   Position: hg19 chr3:45,265,958-45,267,779 Size: 1,822 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr3:45,266,617-45,267,519 Size: 903 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2025-04-10 15:10:12

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:45,265,958-45,267,779)mRNA (may differ from genome)Protein (300 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIneXtProtPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM158_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 158; AltName: Full=40 kDa BINP-binding protein; Short=p40BBP; AltName: Full=Ras-induced senescence protein 1; Flags: Precursor;
FUNCTION: Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
INDUCTION: Up-regulated during Ras-induced senesence.
PTM: N-glycosylated (By similarity).
SIMILARITY: Belongs to the TMEM158 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM158
Diseases sorted by gene-association score: brain injury (19)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 53.48 RPKM in Brain - Nucleus accumbens (basal ganglia)
Total median expression: 328.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -140.40260-0.540 Picture PostScript Text
3' UTR -180.60659-0.274 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8WZ71
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0042277 peptide binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF212329 - JP 2014500723-A/19832: Polycomb-Associated Non-Coding RNAs.
LP896289 - Sequence 1153 from Patent EP3253886.
LF208683 - JP 2014500723-A/16186: Polycomb-Associated Non-Coding RNAs.
LF213960 - JP 2014500723-A/21463: Polycomb-Associated Non-Coding RNAs.
AL080235 - Homo sapiens mRNA; cDNA DKFZp586E1621 (from clone DKFZp586E1621).
AF438313 - Homo sapiens Ras-induced senescence 1 (RIS1) mRNA, complete cds.
BC057390 - Homo sapiens transmembrane protein 158, mRNA (cDNA clone MGC:57838 IMAGE:6175193), complete cds.
JD448573 - Sequence 429597 from Patent EP1572962.
LF378964 - JP 2014500723-A/186467: Polycomb-Associated Non-Coding RNAs.
JD483568 - Sequence 464592 from Patent EP1572962.
LF378965 - JP 2014500723-A/186468: Polycomb-Associated Non-Coding RNAs.
JD147308 - Sequence 128332 from Patent EP1572962.
JD507827 - Sequence 488851 from Patent EP1572962.
JD043283 - Sequence 24307 from Patent EP1572962.
JD344917 - Sequence 325941 from Patent EP1572962.
AB078417 - Homo sapiens hbbp mRNA for p40BBp, complete cds.
JD458515 - Sequence 439539 from Patent EP1572962.
JD404652 - Sequence 385676 from Patent EP1572962.
JD458232 - Sequence 439256 from Patent EP1572962.
MA449537 - JP 2018138019-A/21463: Polycomb-Associated Non-Coding RNAs.
MA447906 - JP 2018138019-A/19832: Polycomb-Associated Non-Coding RNAs.
MA444260 - JP 2018138019-A/16186: Polycomb-Associated Non-Coding RNAs.
MA614541 - JP 2018138019-A/186467: Polycomb-Associated Non-Coding RNAs.
MA614542 - JP 2018138019-A/186468: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000503771.1, HBBP, NM_015444, Q6PFW5, Q8WZ71, Q9Y4M1, RIS1, TM158_HUMAN, uc322xpz.1, uc322xpz.2
UCSC ID: ENST00000503771.2_6
RefSeq Accession: NM_015444.3
Protein: Q8WZ71 (aka TM158_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.