Human Gene TMEM143 (ENST00000293261.8_10) from GENCODE V47lift37

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Description: transmembrane protein 143, transcript variant 1 (from RefSeq NM_018273.4)
Gencode Transcript: ENST00000293261.8_10
Gencode Gene: ENSG00000161558.11_15
Transcript (Including UTRs)
Position: hg19 chr19:48,835,613-48,867,197 Size: 31,585 Total Exon Count: 8 Strand: -
Coding Region
Position: hg19 chr19:48,836,476-48,867,177 Size: 30,702 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:48,835,613-48,867,197)			mRNA (may differ from genome)		Protein (459 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TM143_HUMAN DESCRIPTION: RecName: Full=Transmembrane protein 143; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D013749 Tetrachlorodibenzodioxin C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 15.61 RPKM in Muscle - Skeletal Total median expression: 213.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-1.50	20	-0.075	Picture	PostScript	Text
3' UTR	-250.50	863	-0.290	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR022227 - DUF3754

Pfam Domains:
PF12576 - Protein of unknown function (DUF3754)

ModBase Predicted Comparative 3D Structure on Q96AN5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function Biological Process: GO:0008150 biological_process Cellular Component: GO:0005739 mitochondrion GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK001784 - Homo sapiens cDNA FLJ10922 fis, clone OVARC1000420. BC040021 - Homo sapiens transmembrane protein 143, mRNA (cDNA clone IMAGE:5787329). AK297610 - Homo sapiens cDNA FLJ57400 complete cds. AK129801 - Homo sapiens cDNA FLJ26290 fis, clone DMC07028. AY358161 - Homo sapiens clone DNA143516 TVEL5922 (UNQ5922) mRNA, complete cds. BC016919 - Homo sapiens transmembrane protein 143, mRNA (cDNA clone MGC:21130 IMAGE:4400601), complete cds. JD525418 - Sequence 506442 from Patent EP1572962. JD322847 - Sequence 303871 from Patent EP1572962. JD306999 - Sequence 288023 from Patent EP1572962. JD522908 - Sequence 503932 from Patent EP1572962. JD223583 - Sequence 204607 from Patent EP1572962. JD155112 - Sequence 136136 from Patent EP1572962. JD092446 - Sequence 73470 from Patent EP1572962. JD062320 - Sequence 43344 from Patent EP1572962. JD213782 - Sequence 194806 from Patent EP1572962. JD371877 - Sequence 352901 from Patent EP1572962. JD188962 - Sequence 169986 from Patent EP1572962. AK291521 - Homo sapiens cDNA FLJ75515 complete cds. AK298317 - Homo sapiens cDNA FLJ57548 complete cds. JD528477 - Sequence 509501 from Patent EP1572962. JD068284 - Sequence 49308 from Patent EP1572962. JD324710 - Sequence 305734 from Patent EP1572962. JD084106 - Sequence 65130 from Patent EP1572962. AK297591 - Homo sapiens cDNA FLJ58915 complete cds. JD506906 - Sequence 487930 from Patent EP1572962. KJ894174 - Synthetic construct Homo sapiens clone ccsbBroadEn_03568 TMEM143 gene, encodes complete protein. JD454801 - Sequence 435825 from Patent EP1572962. JD374268 - Sequence 355292 from Patent EP1572962. JD103671 - Sequence 84695 from Patent EP1572962. AK303635 - Homo sapiens cDNA FLJ58971 complete cds. AK294408 - Homo sapiens cDNA FLJ57361 complete cds. JD466847 - Sequence 447871 from Patent EP1572962. JD240364 - Sequence 221388 from Patent EP1572962. JD118812 - Sequence 99836 from Patent EP1572962. JD455907 - Sequence 436931 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K656, ENST00000293261.1, ENST00000293261.2, ENST00000293261.3, ENST00000293261.4, ENST00000293261.5, ENST00000293261.6, ENST00000293261.7, NM_018273, Q6UXY4, Q96AN5, Q9NV49, TM143_HUMAN, uc317ldd.1, uc317ldd.2, UNQ5922/PRO19813 UCSC ID: ENST00000293261.8_10 RefSeq Accession: NM_018273.4 Protein: Q96AN5 (aka TM143_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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