Human Gene ARHGAP42 (ENST00000298815.13

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Human Gene ARHGAP42 (ENST00000298815.13_5) from GENCODE V47lift37

Description: Rho GTPase activating protein 42, transcript variant 1 (from RefSeq NM_152432.4)
Gencode Transcript: ENST00000298815.13_5
Gencode Gene: ENSG00000165895.19_9
Transcript (Including UTRs)
Position: hg19 chr11:100,558,019-100,864,672 Size: 306,654 Total Exon Count: 24 Strand: +
Coding Region
Position: hg19 chr11:100,558,410-100,859,532 Size: 301,123 Coding Exon Count: 24

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:100,558,019-100,864,672)			mRNA (may differ from genome)		Protein (874 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RHG42_HUMAN DESCRIPTION: RecName: Full=Rho GTPase-activating protein 42; AltName: Full=Rho GTPase-activating protein 10-like; AltName: Full=Rho-type GTPase-activating protein 42; FUNCTION: May act as a GTPase activator (By similarity). SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 Rho-GAP domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAB71456.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BF511460; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D018817 N-Methyl-3,4-methylenedioxyamphetamine C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 4.39 RPKM in Nerve - Tibial Total median expression: 68.30 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-184.80	391	-0.473	Picture	PostScript	Text
3' UTR	-1244.40	5140	-0.242	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013606 - IRSp53/MIM_homology_IMD
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR001452 - SH3_domain

Pfam Domains:
PF00018 - SH3 domain
PF00169 - PH domain
PF00620 - RhoGAP domain
PF14604 - Variant SH3 domain
PF16746 - BAR domain of APPL family

SCOP Domains:
48350 - GTPase activation domain, GAP
48371 - ARM repeat
48431 - Lipovitellin-phosvitin complex, superhelical domain
103657 - BAR/IMD domain-like
158560 - BH3980-like
50044 - SH3-domain
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on A6NI28


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005096 GTPase activator activity Biological Process: GO:0003085 negative regulation of systemic arterial blood pressure GO:0007165 signal transduction GO:0035024 negative regulation of Rho protein signal transduction GO:0090630 activation of GTPase activity GO:1904694 negative regulation of vascular smooth muscle contraction Cellular Component: GO:0005575 cellular_component

Descriptions from all associated GenBank mRNAs


	JD162365 - Sequence 143389 from Patent EP1572962. AK057372 - Homo sapiens cDNA FLJ32810 fis, clone TESTI2002729, weakly similar to Homo sapiens mRNA for oligophrenin 1. JD290340 - Sequence 271364 from Patent EP1572962. DQ577449 - Homo sapiens piRNA piR-45561, complete sequence. AK023666 - Homo sapiens cDNA FLJ13604 fis, clone PLACE1010401. JD182894 - Sequence 163918 from Patent EP1572962. JD284181 - Sequence 265205 from Patent EP1572962. JD500135 - Sequence 481159 from Patent EP1572962. AK314174 - Homo sapiens cDNA, FLJ94892, highly similar to Homo sapiens AD031 protein (AD031), mRNA. AF247167 - Homo sapiens AD031 mRNA, complete cds. JD092919 - Sequence 73943 from Patent EP1572962. JD288021 - Sequence 269045 from Patent EP1572962. BC112050 - Homo sapiens transmembrane protein 133, mRNA (cDNA clone MGC:138255 IMAGE:8327518), complete cds. BC093843 - Homo sapiens transmembrane protein 133, mRNA (cDNA clone MGC:120878 IMAGE:7939688), complete cds. BC058024 - Homo sapiens transmembrane protein 133, mRNA (cDNA clone IMAGE:4251720), with apparent retained intron. JD508135 - Sequence 489159 from Patent EP1572962. KJ894916 - Synthetic construct Homo sapiens clone ccsbBroadEn_04310 TMEM133 gene, encodes complete protein. JD383420 - Sequence 364444 from Patent EP1572962. JD114324 - Sequence 95348 from Patent EP1572962. JD295037 - Sequence 276061 from Patent EP1572962. JD046974 - Sequence 27998 from Patent EP1572962. JD195144 - Sequence 176168 from Patent EP1572962. JD347704 - Sequence 328728 from Patent EP1572962. JD233681 - Sequence 214705 from Patent EP1572962. JD181770 - Sequence 162794 from Patent EP1572962. JD082574 - Sequence 63598 from Patent EP1572962. JD376954 - Sequence 357978 from Patent EP1572962. JD262696 - Sequence 243720 from Patent EP1572962. JD353247 - Sequence 334271 from Patent EP1572962. JD053916 - Sequence 34940 from Patent EP1572962. JD295538 - Sequence 276562 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein A6NI28 (Reactome details) participates in the following event(s): R-HSA-194922 GAPs inactivate Rho GTPase:GTP by hydrolysis R-HSA-194840 Rho GTPase cycle R-HSA-194315 Signaling by Rho GTPases R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: A6NI28, ARHGAP42 , ENST00000298815.1, ENST00000298815.10, ENST00000298815.11, ENST00000298815.12, ENST00000298815.2, ENST00000298815.3, ENST00000298815.4, ENST00000298815.5, ENST00000298815.6, ENST00000298815.7, ENST00000298815.8, ENST00000298815.9, GRAF3 , NM_152432, Q96M56, RHG42_HUMAN, TMEM133 , uc317mge.1, uc317mge.2 UCSC ID: ENST00000298815.13_5 RefSeq Accession: NM_152432.4 Protein: A6NI28 (aka RHG42_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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