Human Gene TMEM108 (ENST00000321871.11_5) from GENCODE V47lift37
  Description: transmembrane protein 108, transcript variant 1 (from RefSeq NM_023943.4)
Gencode Transcript: ENST00000321871.11_5
Gencode Gene: ENSG00000144868.14_10
Transcript (Including UTRs)
   Position: hg19 chr3:132,757,235-133,116,619 Size: 359,385 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr3:132,948,156-133,114,830 Size: 166,675 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:132,757,235-133,116,619)mRNA (may differ from genome)Protein (575 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM108_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 108; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.43 RPKM in Testis
Total median expression: 43.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.90210-0.271 Picture PostScript Text
3' UTR -471.801789-0.264 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15759 - TMEM108 family

ModBase Predicted Comparative 3D Structure on Q6UXF1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0006898 receptor-mediated endocytosis
GO:0008090 retrograde axonal transport
GO:0008150 biological_process
GO:0021542 dentate gyrus development
GO:0031175 neuron projection development
GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway
GO:0097106 postsynaptic density organization
GO:0097484 dendrite extension
GO:0098815 modulation of excitatory postsynaptic potential
GO:1990416 cellular response to brain-derived neurotrophic factor stimulus

Cellular Component:
GO:0005575 cellular_component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0036477 somatodendritic compartment
GO:0042995 cell projection
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:1904115 axon cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AY358381 - Homo sapiens clone DNA87185 KRSL1875 (UNQ1875) mRNA, complete cds.
BC000568 - Homo sapiens transmembrane protein 108, mRNA (cDNA clone MGC:3040 IMAGE:3163990), complete cds.
AK095050 - Homo sapiens cDNA FLJ37731 fis, clone BRHIP2020743, moderately similar to Transmembrane protein 108 precursor.
AB051477 - Homo sapiens mRNA for KIAA1690 protein, partial cds.
CU674278 - Synthetic construct Homo sapiens gateway clone IMAGE:100017711 5' read TMEM108 mRNA.
KJ894614 - Synthetic construct Homo sapiens clone ccsbBroadEn_04008 TMEM108 gene, encodes complete protein.
JD530479 - Sequence 511503 from Patent EP1572962.
JD308747 - Sequence 289771 from Patent EP1572962.
JD372696 - Sequence 353720 from Patent EP1572962.
JD332766 - Sequence 313790 from Patent EP1572962.
AL136578 - Homo sapiens mRNA; cDNA DKFZp761C0824 (from clone DKFZp761C0824).
JD503763 - Sequence 484787 from Patent EP1572962.
JD531957 - Sequence 512981 from Patent EP1572962.
JD176812 - Sequence 157836 from Patent EP1572962.
JD426140 - Sequence 407164 from Patent EP1572962.
JD372453 - Sequence 353477 from Patent EP1572962.
JD393527 - Sequence 374551 from Patent EP1572962.
JD280519 - Sequence 261543 from Patent EP1572962.
JD324636 - Sequence 305660 from Patent EP1572962.
JD089019 - Sequence 70043 from Patent EP1572962.
JD235229 - Sequence 216253 from Patent EP1572962.
JD111303 - Sequence 92327 from Patent EP1572962.
JD496855 - Sequence 477879 from Patent EP1572962.
JD113108 - Sequence 94132 from Patent EP1572962.
JD516652 - Sequence 497676 from Patent EP1572962.
JD381632 - Sequence 362656 from Patent EP1572962.
JD160588 - Sequence 141612 from Patent EP1572962.
JD332813 - Sequence 313837 from Patent EP1572962.
JD556071 - Sequence 537095 from Patent EP1572962.
JD350676 - Sequence 331700 from Patent EP1572962.
JD524282 - Sequence 505306 from Patent EP1572962.
JD328821 - Sequence 309845 from Patent EP1572962.
JD474128 - Sequence 455152 from Patent EP1572962.
JD338251 - Sequence 319275 from Patent EP1572962.
JD372161 - Sequence 353185 from Patent EP1572962.
JD395239 - Sequence 376263 from Patent EP1572962.
JD045668 - Sequence 26692 from Patent EP1572962.
JD555742 - Sequence 536766 from Patent EP1572962.
JD093140 - Sequence 74164 from Patent EP1572962.
JD347640 - Sequence 328664 from Patent EP1572962.
JD196616 - Sequence 177640 from Patent EP1572962.
JD226242 - Sequence 207266 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DNC9, ENST00000321871.1, ENST00000321871.10, ENST00000321871.2, ENST00000321871.3, ENST00000321871.4, ENST00000321871.5, ENST00000321871.6, ENST00000321871.7, ENST00000321871.8, ENST00000321871.9, KIAA1690, NM_023943, Q6UXF1, Q9BQH1, Q9BW81, Q9C0H3, RTLN, TM108_HUMAN, TMEM108 , uc317rdt.1, uc317rdt.2, UNQ1875/PRO4318
UCSC ID: ENST00000321871.11_5
RefSeq Accession: NM_023943.4
Protein: Q6UXF1 (aka TM108_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.