Human Gene TMEM100 (ENST00000424486.3_8) from GENCODE V47lift37
  Description: transmembrane protein 100, transcript variant 2 (from RefSeq NM_018286.3)
Gencode Transcript: ENST00000424486.3_8
Gencode Gene: ENSG00000166292.12_10
Transcript (Including UTRs)
   Position: hg19 chr17:53,796,988-53,800,225 Size: 3,238 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr17:53,798,027-53,798,431 Size: 405 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:53,796,988-53,800,225)mRNA (may differ from genome)Protein (134 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM100_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 100;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 74.36 RPKM in Lung
Total median expression: 256.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -81.30311-0.261 Picture PostScript Text
3' UTR -243.501039-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF16311 - Transmembrane protein 100

ModBase Predicted Comparative 3D Structure on Q9NV29
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0005515 protein binding

Biological Process:
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001701 in utero embryonic development
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
GO:0030509 BMP signaling pathway
GO:0043491 protein kinase B signaling
GO:0045603 positive regulation of endothelial cell differentiation
GO:0050848 regulation of calcium-mediated signaling
GO:0051930 regulation of sensory perception of pain
GO:0060842 arterial endothelial cell differentiation
GO:0071773 cellular response to BMP stimulus
GO:2001214 positive regulation of vasculogenesis

Cellular Component:
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043204 perikaryon
GO:0048471 perinuclear region of cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK001832 - Homo sapiens cDNA FLJ10970 fis, clone PLACE1000948.
JD305873 - Sequence 286897 from Patent EP1572962.
JD552923 - Sequence 533947 from Patent EP1572962.
JD272595 - Sequence 253619 from Patent EP1572962.
BC010128 - Homo sapiens transmembrane protein 100, mRNA (cDNA clone MGC:19509 IMAGE:3952255), complete cds.
AK095175 - Homo sapiens cDNA FLJ37856 fis, clone BRSSN2014685, highly similar to Transmembrane protein 100.
JD284210 - Sequence 265234 from Patent EP1572962.
JD053232 - Sequence 34256 from Patent EP1572962.
JD046367 - Sequence 27391 from Patent EP1572962.
JD239213 - Sequence 220237 from Patent EP1572962.
JD539263 - Sequence 520287 from Patent EP1572962.
JD176897 - Sequence 157921 from Patent EP1572962.
JD102461 - Sequence 83485 from Patent EP1572962.
JD357541 - Sequence 338565 from Patent EP1572962.
JD278011 - Sequence 259035 from Patent EP1572962.
KJ894175 - Synthetic construct Homo sapiens clone ccsbBroadEn_03569 TMEM100 gene, encodes complete protein.
AB464310 - Synthetic construct DNA, clone: pF1KB7087, Homo sapiens TMEM100 gene for transmembrane protein 100, without stop codon, in Flexi system.
JD061045 - Sequence 42069 from Patent EP1572962.
JD266226 - Sequence 247250 from Patent EP1572962.
JD132830 - Sequence 113854 from Patent EP1572962.
JD554560 - Sequence 535584 from Patent EP1572962.
JD559558 - Sequence 540582 from Patent EP1572962.
JD244839 - Sequence 225863 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DTY7, ENST00000424486.1, ENST00000424486.2, I3L214, NM_018286, Q96FZ0, Q9NV29, TM100_HUMAN, uc319ttk.1, uc319ttk.2
UCSC ID: ENST00000424486.3_8
RefSeq Accession: NM_018286.3
Protein: Q9NV29 (aka TM100_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.