Human Gene TKT (ENST00000462138.6_8) from GENCODE V47lift37
Description: transketolase, transcript variant 5 (from RefSeq NR_047580.2)Gencode Transcript: ENST00000462138.6_8Gencode Gene: ENSG00000163931.17_10Transcript (Including UTRs) Position: hg19 chr3:53,258,728-53,290,038 Size: 31,311 Total Exon Count: 14 Strand: -Coding Region Position: hg19 chr3:53,259,772-53,289,958 Size: 30,187 Coding Exon Count: 14
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: TKT
Diseases sorted by gene-association score: short stature, developmental delay, and congenital heart defects * (1241), transketolase deficiency * (750), wernicke-korsakoff syndrome (45), beriberi (33), wernicke encephalopathy (17), transaldolase deficiency (12), herpes simplex virus keratitis (8), adamantinoma of long bones (8), uremic neuropathy (7), epicondylitis (6), dirofilariasis (6), patent foramen ovale (5), pfeiffer syndrome (4), nasopharyngeal carcinoma (2)* = Manually curated disease association
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
D000082
Acetaminophen
D019256
Cadmium Chloride
D003993
Dibutyl Phthalate
D005411
Flame Retardants
D011794
Quercetin
D013749
Tetrachlorodibenzodioxin
C006780
bisphenol A
C086401
pentabromodiphenyl ether
C006253
pirinixic acid
C049325
1,2-dithiol-3-thione
C029790
2,2',3',4,4',5-hexachlorobiphenyl
C483839
2,2',3,4,4',5',6-heptabromodiphenyl ether
D015073
2-Acetylaminofluorene
C049584
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
C017906
3-dinitrobenzene
D015127
9,10-Dimethyl-1,2-benzanthracene
D016604
Aflatoxin B1
D000643
Ammonium Chloride
D001151
Arsenic
C038328
BEP protocol
C423844
BL 11282
D001554
Benzene
D001564
Benzo(a)pyrene
D002220
Carbamazepine
D002794
Choline
D003042
Cocaine
D003300
Copper
D004041
Dietary Fats
D004052
Diethylnitrosamine
D004237
Diuron
D004997
Ethinyl Estradiol
D005485
Flutamide
D005492
Folic Acid
D005664
Furazolidone
D019833
Genistein
D005839
Gentamicins
D015474
Isotretinoin
D008070
Lipopolysaccharides
D008094
Lithium
D008715
Methionine
D008770
Methylnitrosourea
D009020
Morphine
D010100
Oxygen
D010634
Phenobarbital
D010672
Phenytoin
D011285
Pregnenolone Carbonitrile
D012643
Selenium
D014212
Tretinoin
D014241
Trichloroethylene
D014635
Valproic Acid
D014810
Vitamin E
C006632
arsenic trioxide
C005948
astaxanthine
C055494
caffeic acid phenethyl ester
C018021
cobaltous chloride
C029892
cupric chloride
C047360
felbamate
C040029
gabapentin
C017363
hexabromobenzene
C089796
hexabromocyclododecane
C029891
lead chloride
C041786
palm oil
C076994
perfluorooctane sulfonic acid
C009277
sodium arsenate
D020122
tert-Butylhydroperoxide
C020806
tetrabromobisphenol A
C555802
tetrabromobisphenol-S-bis(2,3-dibromopropyl ether)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
BX647248 - Homo sapiens mRNA; cDNA DKFZp686B0599 (from clone DKFZp686B0599).LF209984 - JP 2014500723-A/17487: Polycomb-Associated Non-Coding RNAs.LF333692 - JP 2014500723-A/141195: Polycomb-Associated Non-Coding RNAs.BC024026 - Homo sapiens transketolase, mRNA (cDNA clone IMAGE:2966643), partial cds.U55017 - Human transketolase (TKT) mRNA, complete cds.X67688 - H.sapiens mRNA for transketolase.BC009970 - Homo sapiens transketolase, mRNA (cDNA clone MGC:15349 IMAGE:4310396), complete cds.EU794667 - Homo sapiens epididymis luminal protein 107 (HEL107) mRNA, complete cds.AK093667 - Homo sapiens cDNA FLJ36348 fis, clone THYMU2007025, highly similar to TRANSKETOLASE (EC 2.2.1.1).AK223614 - Homo sapiens mRNA for transketolase variant, clone: FCC133E07.AX748252 - Sequence 1777 from Patent EP1308459.AK289454 - Homo sapiens cDNA FLJ76204 complete cds, highly similar to Homo sapiens transketolase (Wernicke-Korsakoff syndrome) (TKT), mRNA.AK303191 - Homo sapiens cDNA FLJ56274 complete cds, highly similar to Transketolase (EC 2.2.1.1).BC008615 - Homo sapiens transketolase, mRNA (cDNA clone IMAGE:4156339), partial cds.GQ472197 - Homo sapiens epididymis secretory protein Li 48 (HEL-S-48) mRNA, partial cds.BX649193 - Homo sapiens mRNA; cDNA DKFZp686J13123 (from clone DKFZp686J13123).BC002433 - Homo sapiens transketolase, mRNA (cDNA clone MGC:2211 IMAGE:3346980), complete cds.AK057092 - Homo sapiens cDNA FLJ32530 fis, clone SMINT2000185, highly similar to TRANSKETOLASE (EC 2.2.1.1).AK092084 - Homo sapiens cDNA FLJ34765 fis, clone NT2NE2002620, highly similar to TRANSKETOLASE (EC 2.2.1.1).AX747348 - Sequence 873 from Patent EP1308459.AK293438 - Homo sapiens cDNA FLJ54957 complete cds, highly similar to Transketolase (EC 2.2.1.1).AK301231 - Homo sapiens cDNA FLJ53217 complete cds, highly similar to Transketolase (EC 2.2.1.1).L12711 - Homo sapiens transketolase (tk) mRNA, complete cds.LF333691 - JP 2014500723-A/141194: Polycomb-Associated Non-Coding RNAs.JD083622 - Sequence 64646 from Patent EP1572962.JD283097 - Sequence 264121 from Patent EP1572962.DQ893078 - Synthetic construct clone IMAGE:100005708; FLH193438.01X; RZPDo839G0378D transketolase (Wernicke-Korsakoff syndrome) (TKT) gene, encodes complete protein.KJ901796 - Synthetic construct Homo sapiens clone ccsbBroadEn_11190 TKT gene, encodes complete protein.KJ897677 - Synthetic construct Homo sapiens clone ccsbBroadEn_07071 TKT gene, encodes complete protein.EU176764 - Synthetic construct Homo sapiens clone IMAGE:100011535; FLH193437.01L; RZPDo839C02256D transketolase (Wernicke-Korsakoff syndrome) (TKT) gene, encodes complete protein.KU178361 - Homo sapiens transketolase isoform 1 (TKT) mRNA, partial cds.KU178362 - Homo sapiens transketolase isoform 2 (TKT) mRNA, complete cds, alternatively spliced.KU178363 - Homo sapiens transketolase isoform 3 (TKT) mRNA, complete cds, alternatively spliced.LF333690 - JP 2014500723-A/141193: Polycomb-Associated Non-Coding RNAs.LF333689 - JP 2014500723-A/141192: Polycomb-Associated Non-Coding RNAs.CU677958 - Synthetic construct Homo sapiens gateway clone IMAGE:100022466 5' read TKT mRNA.LF333687 - JP 2014500723-A/141190: Polycomb-Associated Non-Coding RNAs.LF333686 - JP 2014500723-A/141189: Polycomb-Associated Non-Coding RNAs.CU679545 - Synthetic construct Homo sapiens gateway clone IMAGE:100018374 5' read TKT mRNA.LF333685 - JP 2014500723-A/141188: Polycomb-Associated Non-Coding RNAs.LF333684 - JP 2014500723-A/141187: Polycomb-Associated Non-Coding RNAs.AK309482 - Homo sapiens cDNA, FLJ99523.LF333683 - JP 2014500723-A/141186: Polycomb-Associated Non-Coding RNAs.LF333680 - JP 2014500723-A/141183: Polycomb-Associated Non-Coding RNAs.JD026374 - Sequence 7398 from Patent EP1572962.LF333679 - JP 2014500723-A/141182: Polycomb-Associated Non-Coding RNAs.JD027998 - Sequence 9022 from Patent EP1572962.JD021707 - Sequence 2731 from Patent EP1572962.JD024657 - Sequence 5681 from Patent EP1572962.JD035459 - Sequence 16483 from Patent EP1572962.LF333666 - JP 2014500723-A/141169: Polycomb-Associated Non-Coding RNAs.MA445561 - JP 2018138019-A/17487: Polycomb-Associated Non-Coding RNAs.MA569269 - JP 2018138019-A/141195: Polycomb-Associated Non-Coding RNAs.MA569268 - JP 2018138019-A/141194: Polycomb-Associated Non-Coding RNAs.MA569267 - JP 2018138019-A/141193: Polycomb-Associated Non-Coding RNAs.MA569266 - JP 2018138019-A/141192: Polycomb-Associated Non-Coding RNAs.MA569264 - JP 2018138019-A/141190: Polycomb-Associated Non-Coding RNAs.MA569263 - JP 2018138019-A/141189: Polycomb-Associated Non-Coding RNAs.MA569262 - JP 2018138019-A/141188: Polycomb-Associated Non-Coding RNAs.MA569261 - JP 2018138019-A/141187: Polycomb-Associated Non-Coding RNAs.MA569260 - JP 2018138019-A/141186: Polycomb-Associated Non-Coding RNAs.MA569257 - JP 2018138019-A/141183: Polycomb-Associated Non-Coding RNAs.MA569256 - JP 2018138019-A/141182: Polycomb-Associated Non-Coding RNAs.MA569243 - JP 2018138019-A/141169: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library NONOXIPENT-PWY - pentose phosphate pathway (non-oxidative branch)
Other Names for This Gene
Alternate Gene Symbols: A0A024R2Z9, ENST00000462138.1, ENST00000462138.2, ENST00000462138.3, ENST00000462138.4, ENST00000462138.5, HEL107 , NR_047580, TKT , uc321doz.1, uc321doz.2, V9HWD9, V9HWD9_HUMANUCSC ID: ENST00000462138.6_8RefSeq Accession: NM_001064.4
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 