Human Gene TKT (ENST00000462138.6_8) from GENCODE V47lift37
  Description: transketolase, transcript variant 5 (from RefSeq NR_047580.2)
Gencode Transcript: ENST00000462138.6_8
Gencode Gene: ENSG00000163931.17_10
Transcript (Including UTRs)
   Position: hg19 chr3:53,258,728-53,290,038 Size: 31,311 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr3:53,259,772-53,289,958 Size: 30,187 Coding Exon Count: 14 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:53,258,728-53,290,038)mRNA (may differ from genome)Protein (623 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TKT
Diseases sorted by gene-association score: short stature, developmental delay, and congenital heart defects* (1241), transketolase deficiency* (750), wernicke-korsakoff syndrome (45), beriberi (33), wernicke encephalopathy (17), transaldolase deficiency (12), herpes simplex virus keratitis (8), adamantinoma of long bones (8), uremic neuropathy (7), epicondylitis (6), dirofilariasis (6), patent foramen ovale (5), pfeiffer syndrome (4), nasopharyngeal carcinoma (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 257.69 RPKM in Whole Blood
Total median expression: 2546.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.4080-0.355 Picture PostScript Text
3' UTR -403.301044-0.386 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Descriptions from all associated GenBank mRNAs
  BX647248 - Homo sapiens mRNA; cDNA DKFZp686B0599 (from clone DKFZp686B0599).
LF209984 - JP 2014500723-A/17487: Polycomb-Associated Non-Coding RNAs.
LF333692 - JP 2014500723-A/141195: Polycomb-Associated Non-Coding RNAs.
BC024026 - Homo sapiens transketolase, mRNA (cDNA clone IMAGE:2966643), partial cds.
U55017 - Human transketolase (TKT) mRNA, complete cds.
X67688 - H.sapiens mRNA for transketolase.
BC009970 - Homo sapiens transketolase, mRNA (cDNA clone MGC:15349 IMAGE:4310396), complete cds.
EU794667 - Homo sapiens epididymis luminal protein 107 (HEL107) mRNA, complete cds.
AK093667 - Homo sapiens cDNA FLJ36348 fis, clone THYMU2007025, highly similar to TRANSKETOLASE (EC 2.2.1.1).
AK223614 - Homo sapiens mRNA for transketolase variant, clone: FCC133E07.
AX748252 - Sequence 1777 from Patent EP1308459.
AK289454 - Homo sapiens cDNA FLJ76204 complete cds, highly similar to Homo sapiens transketolase (Wernicke-Korsakoff syndrome) (TKT), mRNA.
AK303191 - Homo sapiens cDNA FLJ56274 complete cds, highly similar to Transketolase (EC 2.2.1.1).
BC008615 - Homo sapiens transketolase, mRNA (cDNA clone IMAGE:4156339), partial cds.
GQ472197 - Homo sapiens epididymis secretory protein Li 48 (HEL-S-48) mRNA, partial cds.
BX649193 - Homo sapiens mRNA; cDNA DKFZp686J13123 (from clone DKFZp686J13123).
BC002433 - Homo sapiens transketolase, mRNA (cDNA clone MGC:2211 IMAGE:3346980), complete cds.
AK057092 - Homo sapiens cDNA FLJ32530 fis, clone SMINT2000185, highly similar to TRANSKETOLASE (EC 2.2.1.1).
AK092084 - Homo sapiens cDNA FLJ34765 fis, clone NT2NE2002620, highly similar to TRANSKETOLASE (EC 2.2.1.1).
AX747348 - Sequence 873 from Patent EP1308459.
AK293438 - Homo sapiens cDNA FLJ54957 complete cds, highly similar to Transketolase (EC 2.2.1.1).
AK301231 - Homo sapiens cDNA FLJ53217 complete cds, highly similar to Transketolase (EC 2.2.1.1).
L12711 - Homo sapiens transketolase (tk) mRNA, complete cds.
LF333691 - JP 2014500723-A/141194: Polycomb-Associated Non-Coding RNAs.
JD083622 - Sequence 64646 from Patent EP1572962.
JD283097 - Sequence 264121 from Patent EP1572962.
DQ893078 - Synthetic construct clone IMAGE:100005708; FLH193438.01X; RZPDo839G0378D transketolase (Wernicke-Korsakoff syndrome) (TKT) gene, encodes complete protein.
KJ901796 - Synthetic construct Homo sapiens clone ccsbBroadEn_11190 TKT gene, encodes complete protein.
KJ897677 - Synthetic construct Homo sapiens clone ccsbBroadEn_07071 TKT gene, encodes complete protein.
EU176764 - Synthetic construct Homo sapiens clone IMAGE:100011535; FLH193437.01L; RZPDo839C02256D transketolase (Wernicke-Korsakoff syndrome) (TKT) gene, encodes complete protein.
KU178361 - Homo sapiens transketolase isoform 1 (TKT) mRNA, partial cds.
KU178362 - Homo sapiens transketolase isoform 2 (TKT) mRNA, complete cds, alternatively spliced.
KU178363 - Homo sapiens transketolase isoform 3 (TKT) mRNA, complete cds, alternatively spliced.
LF333690 - JP 2014500723-A/141193: Polycomb-Associated Non-Coding RNAs.
LF333689 - JP 2014500723-A/141192: Polycomb-Associated Non-Coding RNAs.
CU677958 - Synthetic construct Homo sapiens gateway clone IMAGE:100022466 5' read TKT mRNA.
LF333687 - JP 2014500723-A/141190: Polycomb-Associated Non-Coding RNAs.
LF333686 - JP 2014500723-A/141189: Polycomb-Associated Non-Coding RNAs.
CU679545 - Synthetic construct Homo sapiens gateway clone IMAGE:100018374 5' read TKT mRNA.
LF333685 - JP 2014500723-A/141188: Polycomb-Associated Non-Coding RNAs.
LF333684 - JP 2014500723-A/141187: Polycomb-Associated Non-Coding RNAs.
AK309482 - Homo sapiens cDNA, FLJ99523.
LF333683 - JP 2014500723-A/141186: Polycomb-Associated Non-Coding RNAs.
LF333680 - JP 2014500723-A/141183: Polycomb-Associated Non-Coding RNAs.
JD026374 - Sequence 7398 from Patent EP1572962.
LF333679 - JP 2014500723-A/141182: Polycomb-Associated Non-Coding RNAs.
JD027998 - Sequence 9022 from Patent EP1572962.
JD021707 - Sequence 2731 from Patent EP1572962.
JD024657 - Sequence 5681 from Patent EP1572962.
JD035459 - Sequence 16483 from Patent EP1572962.
LF333666 - JP 2014500723-A/141169: Polycomb-Associated Non-Coding RNAs.
MA445561 - JP 2018138019-A/17487: Polycomb-Associated Non-Coding RNAs.
MA569269 - JP 2018138019-A/141195: Polycomb-Associated Non-Coding RNAs.
MA569268 - JP 2018138019-A/141194: Polycomb-Associated Non-Coding RNAs.
MA569267 - JP 2018138019-A/141193: Polycomb-Associated Non-Coding RNAs.
MA569266 - JP 2018138019-A/141192: Polycomb-Associated Non-Coding RNAs.
MA569264 - JP 2018138019-A/141190: Polycomb-Associated Non-Coding RNAs.
MA569263 - JP 2018138019-A/141189: Polycomb-Associated Non-Coding RNAs.
MA569262 - JP 2018138019-A/141188: Polycomb-Associated Non-Coding RNAs.
MA569261 - JP 2018138019-A/141187: Polycomb-Associated Non-Coding RNAs.
MA569260 - JP 2018138019-A/141186: Polycomb-Associated Non-Coding RNAs.
MA569257 - JP 2018138019-A/141183: Polycomb-Associated Non-Coding RNAs.
MA569256 - JP 2018138019-A/141182: Polycomb-Associated Non-Coding RNAs.
MA569243 - JP 2018138019-A/141169: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
NONOXIPENT-PWY - pentose phosphate pathway (non-oxidative branch)

-  Other Names for This Gene
  Alternate Gene Symbols: A0A024R2Z9, ENST00000462138.1, ENST00000462138.2, ENST00000462138.3, ENST00000462138.4, ENST00000462138.5, HEL107 , NR_047580, TKT , uc321doz.1, uc321doz.2, V9HWD9, V9HWD9_HUMAN
UCSC ID: ENST00000462138.6_8
RefSeq Accession: NM_001064.4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.