Human Gene THAP11 (ENST00000303596.3_4) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: THA11_HUMAN
DESCRIPTION: RecName: Full=THAP domain-containing protein 11;
FUNCTION: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
SUBUNIT: Interacts (via coiled coil domain) with HCFC1 (By similarity).
INTERACTION: P70677:Casp3 (xeno); NbExp=2; IntAct=EBI-1790529, EBI-1790419; Q13363:CTBP1; NbExp=2; IntAct=EBI-1790529, EBI-908846; P51610:HCFC1; NbExp=2; IntAct=EBI-1790529, EBI-396176;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity). Note=May be regulated by shuttling of the protein between the cytoplasm and nucleus (By similarity).
POLYMORPHISM: The length of the poly-Gln region is variable in the population.
SIMILARITY: Belongs to the THAP11 family.
SIMILARITY: Contains 1 THAP-type zinc finger.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR006612 - Znf_C2CH
Pfam Domains:
PF05485 - THAP domain
SCOP Domains:
81995 - beta-sandwich domain of Sec23/24
52540 - P-loop containing nucleoside triphosphate hydrolases
56954 - Outer membrane efflux proteins (OEP)
57716 - Glucocorticoid receptor-like (DNA-binding domain)
Protein Data Bank (PDB) 3-D Structure
MuPIT help
ModBase Predicted Comparative 3D Structure on Q96EK4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function:
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0045171 intercellular bridge
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Descriptions from all associated GenBank mRNAs
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LF208284 - JP 2014500723-A/15787: Polycomb-Associated Non-Coding RNAs.
AK289367 - Homo sapiens cDNA FLJ76985 complete cds, highly similar to Homo sapiens THAP domain containing 11 (THAP11), mRNA.
BC012182 - Homo sapiens THAP domain containing 11, mRNA (cDNA clone MGC:20469 IMAGE:4554554), complete cds.
L10378 - Human (clone CTG-B43a) mRNA sequence.
L10379 - Human (clone CTG-B45d) mRNA sequence.
DQ892600 - Synthetic construct clone IMAGE:100005230; FLH188087.01X; RZPDo839G04150D THAP domain containing 11 (THAP11) gene, encodes complete protein.
DQ895831 - Synthetic construct Homo sapiens clone IMAGE:100010291; FLH188083.01L; RZPDo839G04149D THAP domain containing 11 (THAP11) gene, encodes complete protein.
CU680258 - Synthetic construct Homo sapiens gateway clone IMAGE:100023372 5' read THAP11 mRNA.
KJ902943 - Synthetic construct Homo sapiens clone ccsbBroadEn_12337 THAP11 gene, encodes complete protein.
EF036502 - Homo sapiens THAP domain-containing protein 11 mRNA, partial cds.
EU869208 - Homo sapiens clone 742.3.16 THAP domain containing 11 (THAP11) mRNA, partial cds.
AB015338 - Homo sapiens HRIHFB2206 mRNA, partial cds.
LF374152 - JP 2014500723-A/181655: Polycomb-Associated Non-Coding RNAs.
MA443861 - JP 2018138019-A/15787: Polycomb-Associated Non-Coding RNAs.
MA609729 - JP 2018138019-A/181655: Polycomb-Associated Non-Coding RNAs.
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Other Names for This Gene
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Alternate Gene Symbols: A4UCT5, A8K002, ENST00000303596.1, ENST00000303596.2, HRIHFB2206, NM_020457, O94795, Q96EK4, THA11_HUMAN, uc317ngo.1, uc317ngo.2
UCSC ID: ENST00000303596.3_4
RefSeq Accession: NM_020457.3
Protein: Q96EK4
(aka THA11_HUMAN or THAB_HUMAN)
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GeneReviews for This Gene
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GeneReviews article(s) related to gene THAP11:
cbl (Disorders of Intracellular Cobalamin Metabolism)
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Gene Model Information
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Click here
for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
