Human Gene STAMBPL1 (ENST00000371926.8_4) from GENCODE V47lift37

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Description: STAM binding protein like 1 (from RefSeq NM_020799.4)
Gencode Transcript: ENST00000371926.8_4
Gencode Gene: ENSG00000138134.12_8
Transcript (Including UTRs)
Position: hg19 chr10:90,640,002-90,683,244 Size: 43,243 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr10:90,661,466-90,682,981 Size: 21,516 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:90,640,002-90,683,244)			mRNA (may differ from genome)		Protein (436 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: STALP_HUMAN DESCRIPTION: RecName: Full=AMSH-like protease; Short=AMSH-LP; EC=3.4.19.-; AltName: Full=STAM-binding protein-like 1; FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains. COFACTOR: Binds 2 zinc ions per subunit. INTERACTION: Q9H0A6:RNF32; NbExp=2; IntAct=EBI-745021, EBI-724829; TISSUE SPECIFICITY: Ubiquitously expressed. DOMAIN: The JAMM motif is essential for the protease activity (By similarity). SIMILARITY: Belongs to the peptidase M67C family. SIMILARITY: Contains 1 MPN (JAB/Mov34) domain. SEQUENCE CAUTION: Sequence=BAA92611.1; Type=Erroneous initiation; Sequence=CAI13863.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C547126 AZM551248 D016604 Aflatoxin B1 D000393 Air Pollutants D001564 Benzo(a)pyrene D002117 Calcitriol D002794 Choline D016572 Cyclosporine D000431 Ethanol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 6.92 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 90.21 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-192.90	447	-0.432	Picture	PostScript	Text
3' UTR	-52.10	263	-0.198	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000555 - JAB1_Mov34_MPN_PAD1

Pfam Domains:
PF01398 - JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PF08969 - USP8 dimerisation domain
PF14464 - Prokaryotic homologs of the JAB domain

SCOP Domains:
140856 - USP8 N-terminal domain-like
116846 - MIT domain
102712 - JAB1/MPN domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2ZNR - X-ray MuPIT

2ZNV - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q96FJ0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0016787 hydrolase activity GO:0046872 metal ion binding GO:0061578 Lys63-specific deubiquitinase activity Biological Process: GO:0006508 proteolysis GO:0016579 protein deubiquitination GO:0070536 protein K63-linked deubiquitination Cellular Component: GO:0005829 cytosol GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	AB037794 - Homo sapiens mRNA for KIAA1373 protein, partial cds. AB385458 - Synthetic construct DNA, clone: pF1KA1373, Homo sapiens STAMBPL1 gene for AMSH-like protease, complete cds, without stop codon, in Flexi system. AK056086 - Homo sapiens cDNA FLJ31524 fis, clone NT2RI2000284, highly similar to AMSH-like protease (EC 3.1.2.15). BC010846 - Homo sapiens STAM binding protein-like 1, mRNA (cDNA clone MGC:8774 IMAGE:3898533), complete cds. JD480990 - Sequence 462014 from Patent EP1572962. BX649096 - Homo sapiens mRNA; cDNA DKFZp686O0744 (from clone DKFZp686O0744). AK092946 - Homo sapiens cDNA FLJ35627 fis, clone SPLEN2011139, highly similar to AMSH-like protease (EC 3.1.2.15). AB010120 - Homo sapiens mRNA for AMSH-LP, complete cds. CU679819 - Synthetic construct Homo sapiens gateway clone IMAGE:100019322 5' read STAMBPL1 mRNA. KJ902970 - Synthetic construct Homo sapiens clone ccsbBroadEn_12364 STAMBPL1 gene, encodes complete protein. AL137439 - Homo sapiens mRNA; cDNA DKFZp761K1824 (from clone DKFZp761K1824). BC069749 - Homo sapiens cDNA clone IMAGE:7262596, with apparent retained intron. BC069782 - Homo sapiens cDNA clone IMAGE:7262608, with apparent retained intron. JD295396 - Sequence 276420 from Patent EP1572962. AK090678 - Homo sapiens cDNA FLJ33359 fis, clone BRACE2005243, highly similar to AMSH-like protease (EC 3.1.2.15). AX746569 - Sequence 94 from Patent EP1308459. JD024753 - Sequence 5777 from Patent EP1572962. JD028782 - Sequence 9806 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q96FJ0 (Reactome details) participates in the following event(s): R-HSA-5689901 Metalloprotease DUBs R-HSA-5688426 Deubiquitination R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: AMSHLP, B3KPA7, ENST00000371926.1, ENST00000371926.2, ENST00000371926.3, ENST00000371926.4, ENST00000371926.5, ENST00000371926.6, ENST00000371926.7, KIAA1373, NM_020799, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4, STALP_HUMAN, STAMBPL1 , uc318jmz.1, uc318jmz.2 UCSC ID: ENST00000371926.8_4 RefSeq Accession: NM_020799.4 Protein: Q96FJ0 (aka STALP_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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