ID:SIAT2_HUMAN DESCRIPTION: RecName: Full=Beta-galactoside alpha-2,6-sialyltransferase 2; Short=Alpha 2,6-ST 2; EC=2.4.99.1; AltName: Full=CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; AltName: Full=ST6Gal II; Short=ST6GalII; Short=hST6Gal II; AltName: Full=Sialyltransferase 2; FUNCTION: Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids. CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl- 2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.74 mM for Gal-beta-1,4-GlcNAc-beta-O-octyl; KM=0.71 mM for Gal-beta-1,4-GlcNAc; KM=0.48 mM for lacto-N-neotetraose; SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). TISSUE SPECIFICITY: Weakly expressed in some tissues, such as small intestine, colon and fetal brain. INDUCTION: By IL6/interleukin-6 and IL8//interleukin-8. SIMILARITY: Belongs to the glycosyltransferase 29 family. SEQUENCE CAUTION: Sequence=AAH08680.1; Type=Erroneous initiation; Sequence=BAB47506.1; Type=Erroneous initiation; WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST6GAL2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96JF0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0005975 carbohydrate metabolic process GO:0006486 protein glycosylation GO:0007275 multicellular organism development GO:0009311 oligosaccharide metabolic process GO:0018279 protein N-linked glycosylation via asparagine GO:0040007 growth GO:0097503 sialylation
AB058780 - Homo sapiens KIAA1877 mRNA for KIAA1877 protein. AB059555 - Homo sapiens ST6Gal II mRNA for alpha 2,6-sialyltransferase, complete cds. AK307784 - Homo sapiens cDNA, FLJ97732. BC008680 - Homo sapiens ST6 beta-galactosamide alpha-2,6-sialyltranferase 2, mRNA (cDNA clone MGC:9765 IMAGE:3856171), complete cds. AX795200 - Sequence 8 from Patent WO03052088. FJ433885 - Homo sapiens isolate EZ ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ST6GAL2) mRNA, partial cds. FJ433884 - Homo sapiens isolate EY ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ST6GAL2) mRNA, partial cds. FJ433883 - Homo sapiens isolate EX ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ST6GAL2) mRNA, partial cds. AK055273 - Homo sapiens cDNA FLJ30711 fis, clone FCBBF2001309. AK095049 - Homo sapiens cDNA FLJ37730 fis, clone BRHIP2020573. AK095653 - Homo sapiens cDNA FLJ38334 fis, clone FCBBF3026236. JD379586 - Sequence 360610 from Patent EP1572962. JD328832 - Sequence 309856 from Patent EP1572962. DQ579361 - Homo sapiens piRNA piR-47473, complete sequence. JD539646 - Sequence 520670 from Patent EP1572962. JD113298 - Sequence 94322 from Patent EP1572962. AJ512141 - Homo sapiens partial mRNA for beta-galactoside alpha-2,6-sialyltransferase (ST6Gal II gene). AB527224 - Synthetic construct DNA, clone: pF1KA1877, Homo sapiens ST6GAL2 gene for ST6 beta-galactosamide alpha-2,6-sialyltranferase 2, without stop codon, in Flexi system. JF432175 - Synthetic construct Homo sapiens clone IMAGE:100073329 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 (ST6GAL2) gene, encodes complete protein. KJ903439 - Synthetic construct Homo sapiens clone ccsbBroadEn_12833 ST6GAL2 gene, encodes complete protein. AX795201 - Sequence 9 from Patent WO03052088. JD453708 - Sequence 434732 from Patent EP1572962. JD255163 - Sequence 236187 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96JF0 (Reactome details) participates in the following event(s):
R-HSA-4085033 ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link) R-HSA-4085001 Sialic acid metabolism R-HSA-446219 Synthesis of substrates in N-glycan biosythesis R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
