Human Gene SPCS1 (ENST00000619898.5_5) from GENCODE V47lift37

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Description: signal peptidase complex subunit 1 (from RefSeq NM_014041.5)
Gencode Transcript: ENST00000619898.5_5
Gencode Gene: ENSG00000114902.14_9
Transcript (Including UTRs)
Position: hg19 chr3:52,740,122-52,745,164 Size: 5,043 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr3:52,740,263-52,741,828 Size: 1,566 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	Microarray Expression
RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:52,740,122-52,745,164)			mRNA (may differ from genome)		Protein (102 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C006780 bisphenol A D000082 Acetaminophen D001564 Benzo(a)pyrene D019256 Cadmium Chloride D019327 Copper Sulfate D007657 Ketone Bodies D013749 Tetrachlorodibenzodioxin C008261 lead acetate C023036 perfluorooctanoic acid D020122 tert-Butylhydroperoxide

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-41.70	141	-0.296	Picture	PostScript	Text
3' UTR	-954.90	3336	-0.286	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Descriptions from all associated GenBank mRNAs


	AX775785 - Sequence 55 from Patent WO03048202. AF092138 - Homo sapiens HSPC033 mRNA, complete cds. AK027426 - Homo sapiens cDNA FLJ14520 fis, clone NT2RM1000867, highly similar to Signal peptidase complex subunit 1 (EC 3.4.-.-). AX775781 - Sequence 51 from Patent WO03048202. AX775783 - Sequence 53 from Patent WO03048202. AX775833 - Sequence 103 from Patent WO03048202. L38852 - Homo sapiens 12kDa signal peptidase subunit mRNA, complete cds. AX775787 - Sequence 57 from Patent WO03048202. BC000884 - Homo sapiens signal peptidase complex subunit 1 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4899 IMAGE:3462307), complete cds. KJ902496 - Synthetic construct Homo sapiens clone ccsbBroadEn_11890 SPCS1 gene, encodes complete protein. JD271929 - Sequence 252953 from Patent EP1572962. JD433694 - Sequence 414718 from Patent EP1572962. JD196162 - Sequence 177186 from Patent EP1572962. JD142620 - Sequence 123644 from Patent EP1572962. JD344051 - Sequence 325075 from Patent EP1572962. JD401717 - Sequence 382741 from Patent EP1572962. JD376112 - Sequence 357136 from Patent EP1572962. JD497856 - Sequence 478880 from Patent EP1572962. JD185887 - Sequence 166911 from Patent EP1572962. JD102114 - Sequence 83138 from Patent EP1572962. JD472600 - Sequence 453624 from Patent EP1572962. JD447284 - Sequence 428308 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A5F9YFS9, A0A5F9YFS9_HUMAN, ENST00000619898.1, ENST00000619898.2, ENST00000619898.3, ENST00000619898.4, NM_014041, SPCS1 , uc327sqt.1, uc327sqt.2 UCSC ID: ENST00000619898.5_5 RefSeq Accession: NM_014041.5

Gene Model Information


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Methods, Credits, and Use Restrictions


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