ID:SNX16_HUMAN DESCRIPTION: RecName: Full=Sorting nexin-16; FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. SUBUNIT: Homooligomer. Interacts with EGFR (By similarity). SUBCELLULAR LOCATION: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Lysosome (By similarity). TISSUE SPECIFICITY: Detected in placenta, lung, liver,heart and pancreas. DOMAIN: The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. SIMILARITY: Belongs to the sorting nexin family. SIMILARITY: Contains 1 PX (phox homology) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P57768
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006622 protein targeting to lysosome GO:0008333 endosome to lysosome transport GO:0015031 protein transport GO:0045022 early endosome to late endosome transport
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
