ID:SMD3_HUMAN DESCRIPTION: RecName: Full=Small nuclear ribonucleoprotein Sm D3; Short=Sm-D3; AltName: Full=snRNP core protein D3; FUNCTION: Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner. SUBUNIT: Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. INTERACTION: P54105:CLNS1A; NbExp=5; IntAct=EBI-372789, EBI-724693; SUBCELLULAR LOCATION: Nucleus. PTM: Methylated on arginine residues by PRMT5 and PRMT7; methylation is required for assembly and biogenesis of snRNPs. PTM: Arg-97 is dimethylated, probably to asymmetric dimethylarginine. MISCELLANEOUS: In the autoimmune disease systemic lupus erythematosus, antinuclear antibodies are developed with Sm specificity. SIMILARITY: Belongs to the snRNP core protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62318
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF384647 - JP 2014500723-A/192150: Polycomb-Associated Non-Coding RNAs. BC034447 - Homo sapiens small nuclear ribonucleoprotein D3 polypeptide 18kDa, mRNA (cDNA clone IMAGE:3868264). CR456583 - Homo sapiens SNRPD3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.SNRPD3). LF322798 - JP 2014500723-A/130301: Polycomb-Associated Non-Coding RNAs. BC000457 - Homo sapiens small nuclear ribonucleoprotein D3 polypeptide 18kDa, mRNA (cDNA clone MGC:8490 IMAGE:2822042), complete cds. BC003150 - Homo sapiens small nuclear ribonucleoprotein D3 polypeptide 18kDa, mRNA (cDNA clone MGC:4005 IMAGE:2822042), complete cds. U15009 - Human SnRNP core protein Sm D3 mRNA, complete cds. AK296173 - Homo sapiens cDNA FLJ51872 complete cds, highly similar to Small nuclear ribonucleoprotein Sm D3. JD247083 - Sequence 228107 from Patent EP1572962. AB451373 - Homo sapiens SNRPD3 mRNA for small nuclear ribonucleoprotein polypeptide D3, partial cds, clone: FLJ08058AAAF. AB463267 - Synthetic construct DNA, clone: pF1KB8465, Homo sapiens SNRPD3 gene for small nuclear ribonucleoprotein D3 polypeptide, without stop codon, in Flexi system. CU013470 - Homo sapiens SNRPD3, mRNA (cDNA clone IMAGE:100000440), complete cds, without stop codon, in Gateway system. AB451249 - Homo sapiens SNRPD3 mRNA for small nuclear ribonucleoprotein polypeptide D3, complete cds, clone: FLJ08058AAAN. CU013182 - Homo sapiens SNRPD3, mRNA (cDNA clone IMAGE:100000536), complete cds, with stop codon, in Gateway system. LF322799 - JP 2014500723-A/130302: Polycomb-Associated Non-Coding RNAs. LF322803 - JP 2014500723-A/130306: Polycomb-Associated Non-Coding RNAs. LF322804 - JP 2014500723-A/130307: Polycomb-Associated Non-Coding RNAs. LF322805 - JP 2014500723-A/130308: Polycomb-Associated Non-Coding RNAs. JD288690 - Sequence 269714 from Patent EP1572962. JD561578 - Sequence 542602 from Patent EP1572962. JD538166 - Sequence 519190 from Patent EP1572962. JD407479 - Sequence 388503 from Patent EP1572962. JD497717 - Sequence 478741 from Patent EP1572962. JD542657 - Sequence 523681 from Patent EP1572962. JD542658 - Sequence 523682 from Patent EP1572962. JD212605 - Sequence 193629 from Patent EP1572962. JD197996 - Sequence 179020 from Patent EP1572962. JD413281 - Sequence 394305 from Patent EP1572962. JD413283 - Sequence 394307 from Patent EP1572962. JD413284 - Sequence 394308 from Patent EP1572962. JD246637 - Sequence 227661 from Patent EP1572962. JD246639 - Sequence 227663 from Patent EP1572962. JD246640 - Sequence 227664 from Patent EP1572962. JC506894 - Sequence 262 from Patent EP2733220. JC738006 - Sequence 262 from Patent WO2014075939. JD365058 - Sequence 346082 from Patent EP1572962. MA620224 - JP 2018138019-A/192150: Polycomb-Associated Non-Coding RNAs. MA558375 - JP 2018138019-A/130301: Polycomb-Associated Non-Coding RNAs. MA558376 - JP 2018138019-A/130302: Polycomb-Associated Non-Coding RNAs. MA558380 - JP 2018138019-A/130306: Polycomb-Associated Non-Coding RNAs. MA558381 - JP 2018138019-A/130307: Polycomb-Associated Non-Coding RNAs. MA558382 - JP 2018138019-A/130308: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_smPathway - Spliceosomal Assembly
Reactome (by CSHL, EBI, and GO)
Protein P62318 (Reactome details) participates in the following event(s):
R-HSA-191790 Loading and methylation of Sm proteins onto SMN Complexes R-HSA-77585 Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA R-HSA-111438 Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA R-HSA-77586 Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA R-HSA-111437 Cleavage of the 3'-end of the Histone Pre-mRNA R-HSA-191786 snRNP complex assembly R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-72107 Formation of the Spliceosomal E complex R-HSA-75083 ATAC spliceosome mediated 3' splice site cleavage, exon ligation R-HSA-75080 Formation of AT-AC A complex R-HSA-75079 Formation of AT-AC C complex R-HSA-191830 snRNP nuclear import and release R-HSA-72124 Formation of the Spliceosomal A Complex R-HSA-191763 snRNP:Snurportin complex formation R-HSA-191784 snRNA Cap hypermethylation R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-75081 Formation of AT-AC B Complex R-HSA-75082 ATAC spliceosome mediated Lariat formation,5' splice site cleavage R-HSA-156661 Formation of Exon Junction Complex R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-8953854 Metabolism of RNA R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72165 mRNA Splicing - Minor Pathway R-HSA-75067 Processing of Capped Intronless Pre-mRNA R-HSA-73856 RNA Polymerase II Transcription Termination R-HSA-72172 mRNA Splicing R-HSA-73857 RNA Polymerase II Transcription R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
