Human Gene SNRPC (ENST00000244520.10_4) from GENCODE V47lift37
  Description: small nuclear ribonucleoprotein polypeptide C, transcript variant 1 (from RefSeq NM_003093.3)
Gencode Transcript: ENST00000244520.10_4
Gencode Gene: ENSG00000124562.10_14
Transcript (Including UTRs)
   Position: hg19 chr6:34,725,282-34,741,634 Size: 16,353 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr6:34,725,321-34,741,347 Size: 16,027 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:34,725,282-34,741,634)mRNA (may differ from genome)Protein (159 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q5TAL4_HUMAN
DESCRIPTION: RecName: Full=U1 small nuclear ribonucleoprotein C; Short=U1 snRNP C; Short=U1-C; Short=U1C;
FUNCTION: Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
SIMILARITY: Belongs to the U1 small nuclear ribonucleoprotein C family.
SIMILARITY: Contains 1 matrin-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SNRPC
Diseases sorted by gene-association score: childhood type dermatomyositis (6), extraosseous chondrosarcoma (5), chondrosarcoma, extraskeletal myxoid (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 79.15 RPKM in Testis
Total median expression: 1646.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -6.9039-0.177 Picture PostScript Text
3' UTR -72.60287-0.253 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017340 - U1_snRNP-C
IPR000690 - Znf_C2H2_matrin
IPR003604 - Znf_U1
IPR013085 - Znf_U1-C

Pfam Domains:
PF06220 - U1 zinc finger

SCOP Domains:
57667 - beta-beta-alpha zinc fingers

ModBase Predicted Comparative 3D Structure on Q5TAL4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0030619 U1 snRNA binding
GO:0046872 metal ion binding
GO:1990446 U1 snRNP binding

Biological Process:
GO:0000387 spliceosomal snRNP assembly
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome

Cellular Component:
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome


-  Descriptions from all associated GenBank mRNAs
  AK311955 - Homo sapiens cDNA, FLJ92223, Homo sapiens small nuclear ribonucleoprotein polypeptide C (SNRPC),mRNA.
AK223098 - Homo sapiens mRNA for small nuclear ribonucleoprotein polypeptide C variant, clone: KAT04768.
BC121082 - Homo sapiens small nuclear ribonucleoprotein polypeptide C, mRNA (cDNA clone MGC:150357 IMAGE:40119776), complete cds.
BC121083 - Homo sapiens small nuclear ribonucleoprotein polypeptide C, mRNA (cDNA clone MGC:150358 IMAGE:40119777), complete cds.
X12517 - Human mRNA for U1 small nuclear RNP-specific C protein.
AB528669 - Synthetic construct DNA, clone: pF1KB6867, Homo sapiens SNRPC gene for small nuclear ribonucleoprotein polypeptide C, without stop codon, in Flexi system.
KJ892176 - Synthetic construct Homo sapiens clone ccsbBroadEn_01570 SNRPC gene, encodes complete protein.
M18465 - Human U1 small nuclear ribonucleoprotein mRNA, 3' end.
LF335638 - JP 2014500723-A/143141: Polycomb-Associated Non-Coding RNAs.
MA571215 - JP 2018138019-A/143141: Polycomb-Associated Non-Coding RNAs.
JD509965 - Sequence 490989 from Patent EP1572962.
JD465615 - Sequence 446639 from Patent EP1572962.
JD289445 - Sequence 270469 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_smPathway - Spliceosomal Assembly

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000244520.1, ENST00000244520.2, ENST00000244520.3, ENST00000244520.4, ENST00000244520.5, ENST00000244520.6, ENST00000244520.7, ENST00000244520.8, ENST00000244520.9, hCG_16077 , NM_003093, Q5TAL4, Q5TAL4_HUMAN, SNRPC , uc317eow.1, uc317eow.2
UCSC ID: ENST00000244520.10_4
RefSeq Accession: NM_003093.3
Protein: Q5TAL4

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.