Human Gene SLAIN2 (ENST00000264313.11_4) from GENCODE V47lift37
  Description: SLAIN motif family member 2 (from RefSeq NM_020846.2)
Gencode Transcript: ENST00000264313.11_4
Gencode Gene: ENSG00000109171.15_7
Transcript (Including UTRs)
   Position: hg19 chr4:48,343,546-48,428,218 Size: 84,673 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr4:48,343,757-48,424,094 Size: 80,338 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:48,343,546-48,428,218)mRNA (may differ from genome)Protein (581 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SLAI2_HUMAN
DESCRIPTION: RecName: Full=SLAIN motif-containing protein 2;
FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase.
SUBUNIT: Interacts with CLIP1, CLIP2, CKAP5, CLASP1, MAPRE1 and MAPRE3.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. Detected at the plus end of growing microtubules.
TISSUE SPECIFICITY: Widely expressed with highest levels in adult liver, testis and ovary, and lowest levels in adult pancreas and spleen and in fetal brain.
DOMAIN: The N-terminus forms a two-stranded coiled coil.
PTM: Is highly phosphorylated during mitosis, but not during interphase. The highly phosphorylated form does not localize at microtubule plus ends and does not interact with MAPRE1 or CKAP5.
SIMILARITY: Belongs to the SLAIN motif-containing family.
SEQUENCE CAUTION: Sequence=AAH31691.2; Type=Erroneous initiation; Sequence=BAA95982.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.40 RPKM in Testis
Total median expression: 435.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -111.20211-0.527 Picture PostScript Text
3' UTR -920.244124-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026179 - Slain

Pfam Domains:
PF15301 - SLAIN motif-containing family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3RDV - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9P270
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0007020 microtubule nucleation
GO:0031113 regulation of microtubule polymerization
GO:0031116 positive regulation of microtubule polymerization
GO:0031122 cytoplasmic microtubule organization

Cellular Component:
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0035371 microtubule plus-end


-  Descriptions from all associated GenBank mRNAs
  AK023949 - Homo sapiens cDNA FLJ13887 fis, clone THYRO1001570.
BC040993 - Homo sapiens SLAIN motif family, member 2, mRNA (cDNA clone MGC:43785 IMAGE:5272534), complete cds.
AK291006 - Homo sapiens cDNA FLJ76171 complete cds.
BC006139 - Homo sapiens, clone IMAGE:3832640, mRNA.
BC007701 - Homo sapiens cDNA clone IMAGE:3954165, partial cds.
BC012067 - Homo sapiens, clone IMAGE:4640438, mRNA.
AB040891 - Homo sapiens KIAA1458 mRNA for KIAA1458 protein.
AB384217 - Synthetic construct DNA, clone: pF1KSDA1458, Homo sapiens SLAIN2 gene for SLAIN motif family, member 2, complete cds, without stop codon, in Flexi system.
KJ894441 - Synthetic construct Homo sapiens clone ccsbBroadEn_03835 SLAIN2 gene, encodes complete protein.
AK026476 - Homo sapiens cDNA: FLJ22823 fis, clone KAIA3974.
LF206864 - JP 2014500723-A/14367: Polycomb-Associated Non-Coding RNAs.
LF358707 - JP 2014500723-A/166210: Polycomb-Associated Non-Coding RNAs.
JD460773 - Sequence 441797 from Patent EP1572962.
MA442441 - JP 2018138019-A/14367: Polycomb-Associated Non-Coding RNAs.
MA594284 - JP 2018138019-A/166210: Polycomb-Associated Non-Coding RNAs.
BC031691 - Homo sapiens SLAIN motif family, member 2, mRNA (cDNA clone IMAGE:4752398), complete cds.
AK025264 - Homo sapiens cDNA: FLJ21611 fis, clone COL07344.
JD085859 - Sequence 66883 from Patent EP1572962.
JD314688 - Sequence 295712 from Patent EP1572962.
JD305328 - Sequence 286352 from Patent EP1572962.
JD305183 - Sequence 286207 from Patent EP1572962.
JD349450 - Sequence 330474 from Patent EP1572962.
JD296967 - Sequence 277991 from Patent EP1572962.
JD319789 - Sequence 300813 from Patent EP1572962.
JD197905 - Sequence 178929 from Patent EP1572962.
JD258163 - Sequence 239187 from Patent EP1572962.
JD504150 - Sequence 485174 from Patent EP1572962.
JD247726 - Sequence 228750 from Patent EP1572962.
JD061599 - Sequence 42623 from Patent EP1572962.
JD372733 - Sequence 353757 from Patent EP1572962.
JD496598 - Sequence 477622 from Patent EP1572962.
JD563846 - Sequence 544870 from Patent EP1572962.
JD337218 - Sequence 318242 from Patent EP1572962.
JD488926 - Sequence 469950 from Patent EP1572962.
JD296355 - Sequence 277379 from Patent EP1572962.
JD173926 - Sequence 154950 from Patent EP1572962.
JD268585 - Sequence 249609 from Patent EP1572962.
JD114226 - Sequence 95250 from Patent EP1572962.
JD207777 - Sequence 188801 from Patent EP1572962.
JD501850 - Sequence 482874 from Patent EP1572962.
JD241594 - Sequence 222618 from Patent EP1572962.
JD307256 - Sequence 288280 from Patent EP1572962.
JD509434 - Sequence 490458 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K4P1, ENST00000264313.1, ENST00000264313.10, ENST00000264313.2, ENST00000264313.3, ENST00000264313.4, ENST00000264313.5, ENST00000264313.6, ENST00000264313.7, ENST00000264313.8, ENST00000264313.9, KIAA1458, NM_020846, Q8N5R3, Q9P270, SLAI2_HUMAN, uc317hrf.1, uc317hrf.2
UCSC ID: ENST00000264313.11_4
RefSeq Accession: NM_020846.2
Protein: Q9P270 (aka SLAI2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.