Human Gene SH3YL1 (ENST00000356150.10_7) from GENCODE V47lift37

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Description: SH3 and SYLF domain containing 1, transcript variant 1 (from RefSeq NM_015677.4)
Gencode Transcript: ENST00000356150.10_7
Gencode Gene: ENSG00000035115.22_12
Transcript (Including UTRs)
Position: hg19 chr2:218,144-264,032 Size: 45,889 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr2:218,811-263,984 Size: 45,174 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:218,144-264,032)			mRNA (may differ from genome)		Protein (342 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: SH3Y1_HUMAN DESCRIPTION: RecName: Full=SH3 domain-containing YSC84-like protein 1; SUBUNIT: Interacts with SH3D19 (By similarity). SIMILARITY: Belongs to the SH3YL1 family. SIMILARITY: Contains 1 SH3 domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D014212 Tretinoin C006780 bisphenol A C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene D000082 Acetaminophen D001564 Benzo(a)pyrene D002117 Calcitriol D002794 Choline D019327 Copper Sulfate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9.90 RPKM in Pancreas Total median expression: 202.49 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-22.00	48	-0.458	Picture	PostScript	Text
3' UTR	-117.40	667	-0.176	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001452 - SH3_domain
IPR007461 - Ysc84_actin-binding

Pfam Domains:
PF00018 - SH3 domain
PF04366 - Las17-binding protein actin regulator
PF07653 - Variant SH3 domain
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D8H - NMR MuPIT

ModBase Predicted Comparative 3D Structure on Q96HL8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0019902 phosphatase binding GO:0035091 phosphatidylinositol binding Biological Process: GO:0006661 phosphatidylinositol biosynthetic process GO:1900027 regulation of ruffle assembly Cellular Component: GO:0032587 ruffle membrane

Descriptions from all associated GenBank mRNAs


	BC008374 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone MGC:12274 IMAGE:3996066), complete cds. BC008375 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone MGC:12275 IMAGE:3996120), complete cds. AK026586 - Homo sapiens cDNA: FLJ22933 fis, clone KAT07516. BC043403 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:6045172), partial cds. AK026507 - Homo sapiens cDNA: FLJ22854 fis, clone KAT00983. AK292312 - Homo sapiens cDNA FLJ78625 complete cds. BC043234 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:5295710). AK055801 - Homo sapiens cDNA FLJ31239 fis, clone KIDNE2004879. BC013286 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:3683474), with apparent retained intron. BC030778 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:4825726), complete cds. BC034974 - Homo sapiens SH3 domain containing, Ysc84-like 1 (S. cerevisiae), mRNA (cDNA clone IMAGE:4825727), complete cds. AK123829 - Homo sapiens cDNA FLJ41835 fis, clone NT2RI3001279, highly similar to Mus musculus mRNA for Sh3yl1. AL050373 - Homo sapiens mRNA; cDNA DKFZp586F1318 (from clone DKFZp586F1318). JD562578 - Sequence 543602 from Patent EP1572962. JD528364 - Sequence 509388 from Patent EP1572962. JD348360 - Sequence 329384 from Patent EP1572962. JD510711 - Sequence 491735 from Patent EP1572962. AK096440 - Homo sapiens cDNA FLJ39121 fis, clone NTONG2006709, highly similar to Mus musculus mRNA for Sh3yl1. CR457361 - Homo sapiens full open reading frame cDNA clone RZPDo834F1213D for gene SH3YL1, SH3 domain containing, Ysc84-like 1 (S. cerevisiae); complete cds, incl. stopcodon. KJ906119 - Synthetic construct Homo sapiens clone ccsbBroadEn_15789 SH3YL1 gene, encodes complete protein. HQ447798 - Synthetic construct Homo sapiens clone IMAGE:100071141; CCSB005551_01 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) (SH3YL1) gene, encodes complete protein. KJ893579 - Synthetic construct Homo sapiens clone ccsbBroadEn_02973 SH3YL1 gene, encodes complete protein. EU831405 - Synthetic construct Homo sapiens clone HAIB:100066434; DKFZo008A0317 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) protein (SH3YL1) gene, encodes complete protein. EU831406 - Synthetic construct Homo sapiens clone HAIB:100066435; DKFZo008A0417 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) protein (SH3YL1) gene, encodes complete protein. EU831497 - Synthetic construct Homo sapiens clone HAIB:100066526; DKFZo004A0318 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) protein (SH3YL1) gene, encodes complete protein. EU831498 - Synthetic construct Homo sapiens clone HAIB:100066527; DKFZo004A0418 SH3 domain containing, Ysc84-like 1 (S. cerevisiae) protein (SH3YL1) gene, encodes complete protein. AB587414 - Synthetic construct DNA, clone: pF1KB6428, Homo sapiens SH3YL1 gene for SH3 domain containing, Ysc84-like 1, without stop codon, in Flexi system. CU678935 - Synthetic construct Homo sapiens gateway clone IMAGE:100018926 5' read SH3YL1 mRNA. CU678933 - Synthetic construct Homo sapiens gateway clone IMAGE:100019022 5' read SH3YL1 mRNA. KJ906118 - Synthetic construct Homo sapiens clone ccsbBroadEn_15788 SH3YL1 gene, encodes complete protein. JD382568 - Sequence 363592 from Patent EP1572962. JD190103 - Sequence 171127 from Patent EP1572962. JD269793 - Sequence 250817 from Patent EP1572962. JD156904 - Sequence 137928 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K8E7, B7WNJ4, B7WPL6, ENST00000356150.1, ENST00000356150.2, ENST00000356150.3, ENST00000356150.4, ENST00000356150.5, ENST00000356150.6, ENST00000356150.7, ENST00000356150.8, ENST00000356150.9, NM_015677, Q8NEL2, Q96HL8, Q9H5X4, Q9Y3V5, SH3Y1_HUMAN, uc317zkv.1, uc317zkv.2 UCSC ID: ENST00000356150.10_7 RefSeq Accession: NM_015677.4 Protein: Q96HL8 (aka SH3Y1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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