Human Gene SFRP5 (ENST00000266066.4_7) from GENCODE V47lift37
  Description: secreted frizzled related protein 5 (from RefSeq NM_003015.3)
Gencode Transcript: ENST00000266066.4_7
Gencode Gene: ENSG00000120057.5_9
Transcript (Including UTRs)
   Position: hg19 chr10:99,526,508-99,531,756 Size: 5,249 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr10:99,527,271-99,531,590 Size: 4,320 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:99,526,508-99,531,756)mRNA (may differ from genome)Protein (317 aa)
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-  Comments and Description Text from UniProtKB
  ID: SFRP5_HUMAN
DESCRIPTION: RecName: Full=Secreted frizzled-related protein 5; Short=sFRP-5; AltName: Full=Frizzled-related protein 1b; Short=FRP-1b; AltName: Full=Secreted apoptosis-related protein 3; Short=SARP-3; Flags: Precursor;
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
SUBCELLULAR LOCATION: Secreted (By similarity).
TISSUE SPECIFICITY: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
DOMAIN: The FZ domain is involved in binding with Wnt ligands (By similarity).
SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP) family.
SIMILARITY: Contains 1 FZ (frizzled) domain.
SIMILARITY: Contains 1 NTR domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SFRP5
Diseases sorted by gene-association score: esophageal basaloid squamous cell carcinoma (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 193.41 RPKM in Nerve - Tibial
Total median expression: 383.96 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.30166-0.544 Picture PostScript Text
3' UTR -299.10763-0.392 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015526 - Frizzled/SFRP
IPR020067 - Frizzled_dom
IPR001134 - Netrin_domain
IPR018933 - Netrin_module_non-TIMP
IPR026561 - SFRP5
IPR008993 - TIMP-like_OB-fold

Pfam Domains:
PF01392 - Fz domain
PF01759 - UNC-6/NTR/C345C module

SCOP Domains:
63501 - Frizzled cysteine-rich domain
50242 - TIMP-like

ModBase Predicted Comparative 3D Structure on Q5T4F7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details  Gene Details 
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 RGDEnsembl WormBase 
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004930 G-protein coupled receptor activity
GO:0017147 Wnt-protein binding
GO:0042813 Wnt-activated receptor activity

Biological Process:
GO:0006915 apoptotic process
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007275 multicellular organism development
GO:0007601 visual perception
GO:0008285 negative regulation of cell proliferation
GO:0009653 anatomical structure morphogenesis
GO:0016055 Wnt signaling pathway
GO:0030111 regulation of Wnt signaling pathway
GO:0030154 cell differentiation
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0035567 non-canonical Wnt signaling pathway
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0051898 negative regulation of protein kinase B signaling
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000057 negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AF117758 - Homo sapiens secreted frizzled-related protein 5 (SFRP5) mRNA, complete cds.
BC050435 - Homo sapiens secreted frizzled-related protein 5, mRNA (cDNA clone MGC:54179 IMAGE:6189478), complete cds.
AF017988 - Homo sapiens secreted apoptosis related protein 3 (SARP3) mRNA, complete cds.
JD525660 - Sequence 506684 from Patent EP1572962.
JD357982 - Sequence 339006 from Patent EP1572962.
JD054702 - Sequence 35726 from Patent EP1572962.
JD536685 - Sequence 517709 from Patent EP1572962.
JD375791 - Sequence 356815 from Patent EP1572962.
JD429496 - Sequence 410520 from Patent EP1572962.
JD410699 - Sequence 391723 from Patent EP1572962.
JD223410 - Sequence 204434 from Patent EP1572962.
JD055696 - Sequence 36720 from Patent EP1572962.
JD473006 - Sequence 454030 from Patent EP1572962.
JD471334 - Sequence 452358 from Patent EP1572962.
JD102372 - Sequence 83396 from Patent EP1572962.
JD515449 - Sequence 496473 from Patent EP1572962.
JD436138 - Sequence 417162 from Patent EP1572962.
JD528702 - Sequence 509726 from Patent EP1572962.
JD090960 - Sequence 71984 from Patent EP1572962.
JD393324 - Sequence 374348 from Patent EP1572962.
JD480653 - Sequence 461677 from Patent EP1572962.
JD476462 - Sequence 457486 from Patent EP1572962.
JD145280 - Sequence 126304 from Patent EP1572962.
JD055114 - Sequence 36138 from Patent EP1572962.
JD474107 - Sequence 455131 from Patent EP1572962.
LF212787 - JP 2014500723-A/20290: Polycomb-Associated Non-Coding RNAs.
LF213447 - JP 2014500723-A/20950: Polycomb-Associated Non-Coding RNAs.
JD055801 - Sequence 36825 from Patent EP1572962.
JD336428 - Sequence 317452 from Patent EP1572962.
JD106336 - Sequence 87360 from Patent EP1572962.
MA448364 - JP 2018138019-A/20290: Polycomb-Associated Non-Coding RNAs.
MA449024 - JP 2018138019-A/20950: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000266066.1, ENST00000266066.2, ENST00000266066.3, FRP1B, NM_003015, O14780, Q5T4F7, Q86TH7, SARP3, SFRP5_HUMAN, uc317igb.1, uc317igb.2
UCSC ID: ENST00000266066.4_7
RefSeq Accession: NM_003015.3
Protein: Q5T4F7 (aka SFRP5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.