Human Gene SEPTIN1 (ENST00000321367.8_10) from GENCODE V47lift37
  Description: septin 1, transcript variant 1 (from RefSeq NM_001365977.2)
Gencode Transcript: ENST00000321367.8_10
Gencode Gene: ENSG00000180096.13_15
Transcript (Including UTRs)
   Position: hg19 chr16:30,389,456-30,393,882 Size: 4,427 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg19 chr16:30,389,755-30,393,863 Size: 4,109 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:30,389,456-30,393,882)mRNA (may differ from genome)Protein (372 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsMGIOMIM
PubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SEPT1_HUMAN
DESCRIPTION: RecName: Full=Septin-1; AltName: Full=LARP; AltName: Full=Peanut-like protein 3; AltName: Full=Serologically defined breast cancer antigen NY-BR-24;
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).
SUBUNIT: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). Interacts with AURKB.
INTERACTION: Q96GD4:AURKB; NbExp=6; IntAct=EBI-693002, EBI-624291;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Cytoplasm, cytoskeleton, centrosome. Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis.
TISSUE SPECIFICITY: Expressed at high levels in lymphoid and hematopoietic tissues.
SIMILARITY: Belongs to the septin family.
SEQUENCE CAUTION: Sequence=AAK61491.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.39 RPKM in Brain - Cerebellum
Total median expression: 3.34 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.7019-0.089 Picture PostScript Text
3' UTR -101.70299-0.340 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000038 - Cell_div_GTP-bd
IPR016491 - Septin

Pfam Domains:
PF00735 - Septin
PF01926 - 50S ribosome-binding GTPase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like

ModBase Predicted Comparative 3D Structure on Q8WYJ6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0042802 identical protein binding

Biological Process:
GO:0007049 cell cycle
GO:0051301 cell division

Cellular Component:
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0030496 midbody


-  Descriptions from all associated GenBank mRNAs
  AF085235 - Homo sapiens LARP mRNA, complete cds.
AY034176 - Homo sapiens septin 1 mRNA, complete cds.
AL833004 - Homo sapiens mRNA; cDNA DKFZp666C094 (from clone DKFZp666C094).
BC012161 - Homo sapiens septin 1, mRNA (cDNA clone MGC:20394 IMAGE:4576220), complete cds.
JD389652 - Sequence 370676 from Patent EP1572962.
JD546931 - Sequence 527955 from Patent EP1572962.
JD395052 - Sequence 376076 from Patent EP1572962.
KJ891050 - Synthetic construct Homo sapiens clone ccsbBroadEn_00444 SEPT1 gene, encodes complete protein.
AK301045 - Homo sapiens cDNA FLJ57867 complete cds, highly similar to Septin-1.
AK303390 - Homo sapiens cDNA FLJ61013 complete cds, highly similar to Septin-1.
JD498630 - Sequence 479654 from Patent EP1572962.
JD347171 - Sequence 328195 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B4DVE6, DIFF6, ENST00000321367.1, ENST00000321367.2, ENST00000321367.3, ENST00000321367.4, ENST00000321367.5, ENST00000321367.6, ENST00000321367.7, NM_001365977, PNUTL3, Q658T1, Q8NEZ1, Q8WYJ6, Q96EL4, Q9H285, SEPT1, SEPT1_HUMAN, SEPTIN1 , uc317rbd.1, uc317rbd.2
UCSC ID: ENST00000321367.8_10
RefSeq Accession: NM_001365977.2
Protein: Q8WYJ6 (aka SEPT1_HUMAN or SEP1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.