ID:RXFP2_HUMAN DESCRIPTION: RecName: Full=Relaxin receptor 2; AltName: Full=G-protein coupled receptor 106; AltName: Full=G-protein coupled receptor affecting testicular descent; AltName: Full=Leucine-rich repeat-containing G-protein coupled receptor 8; AltName: Full=Relaxin family peptide receptor 2; FUNCTION: Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow. DISEASE: Defects in RXFP2 are a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. SIMILARITY: Contains 1 LDL-receptor class A domain. SIMILARITY: Contains 10 LRR (leucine-rich) repeats. CAUTION: It is uncertain whether Met-1 or Met-18 is the initiator.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00001 - 7 transmembrane receptor (rhodopsin family) PF00057 - Low-density lipoprotein receptor domain class A PF13306 - BspA type Leucine rich repeat region (6 copies) PF13855 - Leucine rich repeat
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 81321 - Family A G protein-coupled receptor-like 90123 - ABC transporter transmembrane region 57424 - LDL receptor-like module
ModBase Predicted Comparative 3D Structure on Q8WXD0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
