ID:RRAGB_HUMAN DESCRIPTION: RecName: Full=Ras-related GTP-binding protein B; Short=Rag B; Short=RagB; FUNCTION: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. Involved in the RCC1/Ran-GTPase pathway. SUBUNIT: The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGA, interacts with RPTOR; this interaction is particularly efficient with GTP-loaded RRAGB and GDP-loaded RRAGC. It is regulated by amino acids, since amino acid stimulation of cells increase the GTP-loading of RRAGB. INTERACTION: Q9HB90:RRAGC; NbExp=4; IntAct=EBI-993049, EBI-752390; Q9NQL2:RRAGD; NbExp=7; IntAct=EBI-993049, EBI-992949; SUBCELLULAR LOCATION: Cytoplasm. Lysosome. SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00025 - ADP-ribosylation factor family PF00071 - Ras family PF01926 - 50S ribosome-binding GTPase PF04670 - Gtr1/RagA G protein conserved region PF08477 - Ras of Complex, Roc, domain of DAPkinase
ModBase Predicted Comparative 3D Structure on Q5VZM2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007050 cell cycle arrest GO:0010506 regulation of autophagy GO:0016241 regulation of macroautophagy GO:0032006 regulation of TOR signaling GO:0032008 positive regulation of TOR signaling GO:0034198 cellular response to amino acid starvation GO:0034613 cellular protein localization GO:0071230 cellular response to amino acid stimulus GO:1904263 positive regulation of TORC1 signaling GO:1990253 cellular response to leucine starvation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
