ID:RPR1B_HUMAN DESCRIPTION: RecName: Full=Regulation of nuclear pre-mRNA domain-containing protein 1B; AltName: Full=Cell cycle-related and expression-elevated protein in tumor; FUNCTION: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. SUBUNIT: Associates with the RNA polymerase II complex. INTERACTION: P24928:POLR2A; NbExp=5; IntAct=EBI-747925, EBI-295301; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Preferentially expressed in a range of tumor tissues including colon, lung, liver, breast, prostate, stomach, uterine endometrium and cervical cancers with higher levels in tumors than in adjacent non-tumor tissue (at protein level). SIMILARITY: Belongs to the UPF0400 (RTT103) family. SIMILARITY: Contains 1 CID domain. SEQUENCE CAUTION: Sequence=AAH01696.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NQG5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000993 RNA polymerase II core binding GO:0005515 protein binding GO:0042802 identical protein binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0008284 positive regulation of cell proliferation GO:0010564 regulation of cell cycle process GO:0042795 snRNA transcription from RNA polymerase II promoter GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain
DQ372938 - Homo sapiens cell-cycle related and expression-elevated protein in tumor (CREPT) mRNA, complete cds. BC033629 - Homo sapiens regulation of nuclear pre-mRNA domain containing 1B, mRNA (cDNA clone MGC:45008 IMAGE:5223673), complete cds. AK312468 - Homo sapiens cDNA, FLJ92823. AB463518 - Synthetic construct DNA, clone: pF1KB6477, Homo sapiens C20orf77 gene for chromosome 20 open reading frame 77, without stop codon, in Flexi system. CU689672 - Synthetic construct Homo sapiens gateway clone IMAGE:100016707 5' read C20orf77 mRNA. KJ899384 - Synthetic construct Homo sapiens clone ccsbBroadEn_08778 RPRD1B gene, encodes complete protein. AK092567 - Homo sapiens cDNA FLJ35248 fis, clone PROST2003583. AX747603 - Sequence 1128 from Patent EP1308459. JD523475 - Sequence 504499 from Patent EP1572962. BC001696 - Homo sapiens regulation of nuclear pre-mRNA domain containing 1B, mRNA (cDNA clone IMAGE:2967326), partial cds. JD395681 - Sequence 376705 from Patent EP1572962. AK126484 - Homo sapiens cDNA FLJ44520 fis, clone UTERU3002768. JD546855 - Sequence 527879 from Patent EP1572962. JD289672 - Sequence 270696 from Patent EP1572962. JD330143 - Sequence 311167 from Patent EP1572962. JD040320 - Sequence 21344 from Patent EP1572962. JD357720 - Sequence 338744 from Patent EP1572962. AL117521 - Homo sapiens mRNA; cDNA DKFZp434P0735 (from clone DKFZp434P0735). JD490430 - Sequence 471454 from Patent EP1572962. JD348300 - Sequence 329324 from Patent EP1572962. JD297576 - Sequence 278600 from Patent EP1572962. JD235984 - Sequence 217008 from Patent EP1572962. JD094359 - Sequence 75383 from Patent EP1572962. JD448029 - Sequence 429053 from Patent EP1572962. JD287051 - Sequence 268075 from Patent EP1572962. JD378407 - Sequence 359431 from Patent EP1572962. JD368570 - Sequence 349594 from Patent EP1572962. JD044902 - Sequence 25926 from Patent EP1572962. JD562966 - Sequence 543990 from Patent EP1572962. JD527182 - Sequence 508206 from Patent EP1572962. JD347971 - Sequence 328995 from Patent EP1572962. BC020939 - Homo sapiens, clone IMAGE:4284339, mRNA. JD454338 - Sequence 435362 from Patent EP1572962. AL080224 - Homo sapiens mRNA; cDNA DKFZp566P1946 (from clone DKFZp566P1946). JD355047 - Sequence 336071 from Patent EP1572962. JD200788 - Sequence 181812 from Patent EP1572962. JD200764 - Sequence 181788 from Patent EP1572962. JD139399 - Sequence 120423 from Patent EP1572962. JD083059 - Sequence 64083 from Patent EP1572962. JD052401 - Sequence 33425 from Patent EP1572962. JD175121 - Sequence 156145 from Patent EP1572962. JD327316 - Sequence 308340 from Patent EP1572962. JD279201 - Sequence 260225 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NQG5 (Reactome details) participates in the following event(s):
R-HSA-6810235 RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain R-HSA-6814885 CBCAP complex binds 7-methylguanosine cap of snRNA R-HSA-6807505 RNA polymerase II transcribes snRNA genes R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
