ID:RN123_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase RNF123; EC=6.3.2.-; AltName: Full=Kip1 ubiquitination-promoting complex protein 1; AltName: Full=RING finger protein 123; FUNCTION: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain. SUBCELLULAR LOCATION: Cytoplasm. PTM: Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation (By similarity). SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 RING-type zinc finger. SEQUENCE CAUTION: Sequence=BAB14139.1; Type=Erroneous initiation; Sequence=BAB15607.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5XPI4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL832034 - Homo sapiens mRNA; cDNA DKFZp451P244 (from clone DKFZp451P244). AK308607 - Homo sapiens cDNA, FLJ98648. BC112900 - Homo sapiens cDNA clone IMAGE:3909203, containing frame-shift errors. AK308130 - Homo sapiens cDNA, FLJ98078. AK126883 - Homo sapiens cDNA FLJ44935 fis, clone BRAMY3017965. BC130632 - Homo sapiens ring finger protein 123, mRNA (cDNA clone MGC:163504 IMAGE:40146663), complete cds. AL832344 - Homo sapiens mRNA; cDNA DKFZp451N085 (from clone DKFZp451N085). AL832138 - Homo sapiens mRNA; cDNA DKFZp686M2210 (from clone DKFZp686M2210). CR627051 - Homo sapiens mRNA; cDNA DKFZp686C2222 (from clone DKFZp686C2222). AK096353 - Homo sapiens cDNA FLJ39034 fis, clone NT2RP7008085, highly similar to Homo sapiens ring finger protein 123 (RNF123), mRNA. AY744152 - Homo sapiens ubiquitin ligase (KPC1) mRNA, complete cds. AB385257 - Synthetic construct DNA, clone: pF1KB9504, Homo sapiens RNF123 gene for E3 ubiquitin-protein ligase RNF123, complete cds, without stop codon, in Flexi system. AM393062 - Synthetic construct Homo sapiens clone IMAGE:100002259 for hypothetical protein (RNF123 gene). AF370367 - Homo sapiens FP1477 mRNA, complete cds. AK090632 - Homo sapiens cDNA FLJ33313 fis, clone BNGH42006135. AX746548 - Sequence 73 from Patent EP1308459. BC057392 - Homo sapiens ring finger protein 123, mRNA (cDNA clone IMAGE:6174547), partial cds. BC041145 - Homo sapiens ring finger protein 123, mRNA (cDNA clone IMAGE:6070768), partial cds. BC088801 - Homo sapiens ring finger protein 123, mRNA (cDNA clone IMAGE:6376662), partial cds. AK026968 - Homo sapiens cDNA: FLJ23315 fis, clone HEP12021. AK022627 - Homo sapiens cDNA FLJ12565 fis, clone NT2RM4000848. AL136729 - Homo sapiens mRNA; cDNA DKFZp434A0610 (from clone DKFZp434A0610). JD020294 - Sequence 1318 from Patent EP1572962. JD028793 - Sequence 9817 from Patent EP1572962. LF208624 - JP 2014500723-A/16127: Polycomb-Associated Non-Coding RNAs. MA444201 - JP 2018138019-A/16127: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q5XPI4 (Reactome details) participates in the following event(s):
R-HSA-6781814 USP19 deubiquitinates RNF123 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-5689880 Ub-specific processing proteases R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-5688426 Deubiquitination R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-597592 Post-translational protein modification R-HSA-1280218 Adaptive Immune System R-HSA-392499 Metabolism of proteins R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
