ID:RMI1_HUMAN DESCRIPTION: RecName: Full=RecQ-mediated genome instability protein 1; AltName: Full=BLM-associated protein of 75 kDa; Short=BLAP75; AltName: Full=FAAP75; FUNCTION: Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability. SUBUNIT: Component of the RMI complex, containing at least TOP3A, RMI1 and RMI2. The RMI complex interacts with BLM. Directly interacts with RMI2, BLM and TOP3A. May bind DHJ. INTERACTION: P54132:BLM; NbExp=7; IntAct=EBI-621339, EBI-621372; SUBCELLULAR LOCATION: Nucleus. Note=Forms foci in response to DNA damage. SIMILARITY: Belongs to the RMI1 family. SEQUENCE CAUTION: Sequence=AAH20606.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH32494.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH39999.1; Type=Frameshift; Positions=375; Sequence=AAH39999.1; Type=Frameshift; Positions=377, 444; Sequence=AAH53549.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH64937.1; Type=Frameshift; Positions=444, 615; Sequence=AAH64937.1; Type=Frameshift; Positions=377, 444; Sequence=CAI13575.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H9A7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF209811 - JP 2014500723-A/17314: Polycomb-Associated Non-Coding RNAs. LF209812 - JP 2014500723-A/17315: Polycomb-Associated Non-Coding RNAs. BC039999 - Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), mRNA (cDNA clone MGC:48732 IMAGE:5554889), complete cds. BC020606 - Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:4774885), partial cds. AK022950 - Homo sapiens cDNA FLJ12888 fis, clone NT2RP2004081. JD302291 - Sequence 283315 from Patent EP1572962. JD351749 - Sequence 332773 from Patent EP1572962. BC044571 - Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5269264), containing frame-shift errors. BC053549 - Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:6012597), partial cds. BC032494 - Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), mRNA (cDNA clone IMAGE:5243551), partial cds. BC064937 - Homo sapiens RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae), mRNA (cDNA clone MGC:70678 IMAGE:6158300), complete cds. JD358553 - Sequence 339577 from Patent EP1572962. JD304958 - Sequence 285982 from Patent EP1572962. KJ903264 - Synthetic construct Homo sapiens clone ccsbBroadEn_12658 RMI1 gene, encodes complete protein. LF331839 - JP 2014500723-A/139342: Polycomb-Associated Non-Coding RNAs. JD314554 - Sequence 295578 from Patent EP1572962. JD286279 - Sequence 267303 from Patent EP1572962. JD528895 - Sequence 509919 from Patent EP1572962. JD314259 - Sequence 295283 from Patent EP1572962. JD507625 - Sequence 488649 from Patent EP1572962. JD511284 - Sequence 492308 from Patent EP1572962. JD154079 - Sequence 135103 from Patent EP1572962. JD203871 - Sequence 184895 from Patent EP1572962. JD509603 - Sequence 490627 from Patent EP1572962. JD280728 - Sequence 261752 from Patent EP1572962. AJ420435 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1561553. JD342907 - Sequence 323931 from Patent EP1572962. JD293145 - Sequence 274169 from Patent EP1572962. JD369708 - Sequence 350732 from Patent EP1572962. JD066758 - Sequence 47782 from Patent EP1572962. JD477115 - Sequence 458139 from Patent EP1572962. JD427991 - Sequence 409015 from Patent EP1572962. JD100990 - Sequence 82014 from Patent EP1572962. JD350569 - Sequence 331593 from Patent EP1572962. JD166621 - Sequence 147645 from Patent EP1572962. JD061389 - Sequence 42413 from Patent EP1572962. JD563190 - Sequence 544214 from Patent EP1572962. JD550752 - Sequence 531776 from Patent EP1572962. MA567416 - JP 2018138019-A/139342: Polycomb-Associated Non-Coding RNAs. MA445388 - JP 2018138019-A/17314: Polycomb-Associated Non-Coding RNAs. MA445389 - JP 2018138019-A/17315: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9H9A7 (Reactome details) participates in the following event(s):
R-HSA-5686398 SPIDR binds BLM:TOP3A:RMI1:RMI2 R-HSA-5685985 EXO1 or DNA2 in complex with BLM or WRN binds initially resected DNA DSBs along with BRIP1 recruitment R-HSA-5686410 BLM mediates dissolution of double Holliday junction R-HSA-5686657 ERCC1:XPF cleaves flaps generated by SSA R-HSA-5693589 D-loop dissociation and strand annealing R-HSA-5693542 Association of RPA complexes with ssDNA at resected DNA DSBs R-HSA-5685994 Long-range resection of DNA DSBs by EXO1 or DNA2 R-HSA-5684887 Activation of CHEK1 at resected DNA DSBs R-HSA-5684882 CHEK1 is recruited to resected DNA DSBs R-HSA-5693561 RAD51 binds BRCA2 at resected DNA DSBs R-HSA-5693580 Association of RAD52 with the RPA complex at resected DNA DSBs R-HSA-5685156 ATR phosphorylates RPA2 R-HSA-5685341 BCDX2 complex stabilizes RAD51 filament R-HSA-5685838 CX3 complex binds D-loop structures R-HSA-5693620 D-loop formation mediated by PALB2, BRCA2 and RAD51 R-HSA-5684875 Binding of ATR:ATRIP to RPA at resected DNA DSBs R-HSA-5693564 Association of RAD51 with RAD52:DNA double-strand break ends R-HSA-5693593 D-loop extension by DNA polymerases R-HSA-5693584 Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) R-HSA-5686440 MUS81:EME1,EME2 cleaves D-loop R-HSA-5685011 ATR activation at DNA DSBs R-HSA-5686642 RAD52 promotes single strand annealing at resected DNA DSBs R-HSA-6799332 ATR phosphorylates TP53 R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates R-HSA-5693537 Resolution of D-Loop Structures R-HSA-5693607 Processing of DNA double-strand break ends R-HSA-5685938 HDR through Single Strand Annealing (SSA) R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) R-HSA-5685942 HDR through Homologous Recombination (HRR) R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange R-HSA-5693579 Homologous DNA Pairing and Strand Exchange R-HSA-5693567 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5693538 Homology Directed Repair R-HSA-5693532 DNA Double-Strand Break Repair R-HSA-73894 DNA Repair R-HSA-69473 G2/M DNA damage checkpoint R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-69481 G2/M Checkpoints R-HSA-5633007 Regulation of TP53 Activity R-HSA-69620 Cell Cycle Checkpoints R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-1640170 Cell Cycle R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
