Human Gene RIC8A (ENST00000526104.6_12) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: RIC8A_HUMAN
DESCRIPTION: RecName: Full=Synembryn-A; AltName: Full=Protein Ric-8A;
FUNCTION: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
SUBUNIT: Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. Interacts (via C-terminus) with RGS14; the interaction stimulates the dissociation of the complex between RGS14 and the active GTP-bound form of GNAI1 (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: Belongs to the synembryn family.
SEQUENCE CAUTION: Sequence=BAB14282.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB14282.1; Type=Frameshift; Positions=397; Sequence=BAB15653.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB55126.1; Type=Frameshift; Positions=48;
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR019318 - Gua_nucleotide_exch_fac_Ric8
IPR008376 - Synembryn
Pfam Domains:
PF10165 - Guanine nucleotide exchange factor synembryn
SCOP Domains:
48371 - ARM repeat
ModBase Predicted Comparative 3D Structure on Q9NPQ8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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LF207960 - JP 2014500723-A/15463: Polycomb-Associated Non-Coding RNAs.
AK026897 - Homo sapiens cDNA: FLJ23244 fis, clone COL02432.
AL136935 - Homo sapiens mRNA; cDNA DKFZp586O0222 (from clone DKFZp586O0222).
JD120836 - Sequence 101860 from Patent EP1572962.
BC121807 - Homo sapiens resistance to inhibitors of cholinesterase 8 homolog A (C. elegans), mRNA (cDNA clone MGC:148074 IMAGE:40108083), complete cds.
BC121808 - Homo sapiens resistance to inhibitors of cholinesterase 8 homolog A (C. elegans), mRNA (cDNA clone MGC:148073 IMAGE:40108080), complete cds.
JD458304 - Sequence 439328 from Patent EP1572962.
BC111499 - Homo sapiens resistance to inhibitors of cholinesterase 8 homolog A (C. elegans), mRNA (cDNA clone MGC:131931 IMAGE:6526180), complete cds.
AL390088 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1987170.
AK314568 - Homo sapiens cDNA, FLJ95396.
BC094717 - Homo sapiens cDNA clone IMAGE:5272094, containing frame-shift errors.
AK225420 - Homo sapiens mRNA for resistance to inhibitors of cholinesterase 8 homolog A variant, clone: HRC08644.
AK027461 - Homo sapiens cDNA FLJ14555 fis, clone NT2RM2001855.
AB464144 - Synthetic construct DNA, clone: pF1KB8299, Homo sapiens RIC8A gene for resistance to inhibitors of cholinesterase 8 homolog A, without stop codon, in Flexi system.
AM393435 - Synthetic construct Homo sapiens clone IMAGE:100001682 for hypothetical protein (RIC8A gene).
KJ903035 - Synthetic construct Homo sapiens clone ccsbBroadEn_12429 RIC8A gene, encodes complete protein.
BX538115 - Homo sapiens mRNA; cDNA DKFZp686O16163 (from clone DKFZp686O16163).
AK022870 - Homo sapiens cDNA FLJ12808 fis, clone NT2RP2002373.
BC011821 - Homo sapiens resistance to inhibitors of cholinesterase 8 homolog A (C. elegans), mRNA (cDNA clone IMAGE:3688123), partial cds.
CU680066 - Synthetic construct Homo sapiens gateway clone IMAGE:100018244 5' read RIC8A mRNA.
KJ903034 - Synthetic construct Homo sapiens clone ccsbBroadEn_12428 RIC8A gene, encodes complete protein.
AK098267 - Homo sapiens cDNA FLJ40948 fis, clone UTERU2009540.
AK027090 - Homo sapiens cDNA: FLJ23437 fis, clone HRC13266.
DQ596814 - Homo sapiens piRNA piR-34880, complete sequence.
LF370509 - JP 2014500723-A/178012: Polycomb-Associated Non-Coding RNAs.
LF370510 - JP 2014500723-A/178013: Polycomb-Associated Non-Coding RNAs.
JD441983 - Sequence 423007 from Patent EP1572962.
JD185159 - Sequence 166183 from Patent EP1572962.
JD189227 - Sequence 170251 from Patent EP1572962.
JD249275 - Sequence 230299 from Patent EP1572962.
DQ577633 - Homo sapiens piRNA piR-45745, complete sequence.
U30173 - Human clone 7A ETS-like protein mRNA, partial sequence.
Z49984 - H.sapiens mRNA for ets-like protein (clone 7A).
D61706 - Homo sapiens mRNA for Ets-like protein, clone: 7A.
JD096224 - Sequence 77248 from Patent EP1572962.
JD221225 - Sequence 202249 from Patent EP1572962.
JD231483 - Sequence 212507 from Patent EP1572962.
JD234750 - Sequence 215774 from Patent EP1572962.
JD549864 - Sequence 530888 from Patent EP1572962.
JD402414 - Sequence 383438 from Patent EP1572962.
LF385518 - JP 2014500723-A/193021: Polycomb-Associated Non-Coding RNAs.
JD552681 - Sequence 533705 from Patent EP1572962.
LF370511 - JP 2014500723-A/178014: Polycomb-Associated Non-Coding RNAs.
MA606086 - JP 2018138019-A/178012: Polycomb-Associated Non-Coding RNAs.
MA606087 - JP 2018138019-A/178013: Polycomb-Associated Non-Coding RNAs.
MA621095 - JP 2018138019-A/193021: Polycomb-Associated Non-Coding RNAs.
MA606088 - JP 2018138019-A/178014: Polycomb-Associated Non-Coding RNAs.
MA443537 - JP 2018138019-A/15463: Polycomb-Associated Non-Coding RNAs.
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000526104.1, ENST00000526104.2, ENST00000526104.3, ENST00000526104.4, ENST00000526104.5, NM_001386941, Q0P508, Q2T9J1, Q7Z352, Q96EZ1, Q96SZ2, Q9H064, Q9H5H3, Q9H9E7, Q9NPQ8, RIC8A_HUMAN, uc324bmb.1, uc324bmb.2
UCSC ID: ENST00000526104.6_12
RefSeq Accession: NM_001286134.2
Protein: Q9NPQ8
(aka RIC8A_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
