Human Gene RHOH (ENST00000381799.10_4) from GENCODE V47lift37

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Description: ras homolog family member H, transcript variant 6 (from RefSeq NM_004310.5)
Gencode Transcript: ENST00000381799.10_4
Gencode Gene: ENSG00000168421.14_11
Transcript (Including UTRs)
Position: hg19 chr4:40,198,651-40,248,587 Size: 49,937 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr4:40,245,007-40,245,582 Size: 576 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:40,198,651-40,248,587)			mRNA (may differ from genome)		Protein (191 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q6ICP4_HUMAN DESCRIPTION: SubName: Full=ARHH protein; SubName: Full=Ras homolog gene family, member H, isoform CRA_a; SubName: Full=cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA; Flags: Fragment; SIMILARITY: Belongs to the small GTPase superfamily. Rho family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: RHOH Diseases sorted by gene-association score: t-cell immunodeficiency with epidermodysplasia verruciformis* (350), hodgkin lymphoma (15), superficial mycosis (5), lymphoma (5), appendicitis (5), t cell deficiency (4) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D000535 Aluminum D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002737 Chloroprene D002794 Choline D004052 Diethylnitrosamine D004147 Dioxins D005492 Folic Acid D005839 Gentamicins more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 15.48 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 42.61 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-192.90	600	-0.322	Picture	PostScript	Text
3' UTR	-901.60	3005	-0.300	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003578 - Small_GTPase_Rho

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q6ICP4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003924 GTPase activity GO:0005525 GTP binding Biological Process: GO:0007264 small GTPase mediated signal transduction GO:0030217 T cell differentiation GO:0045576 mast cell activation Cellular Component: GO:0001772 immunological synapse GO:0005622 intracellular GO:0005737 cytoplasm GO:0005886 plasma membrane

Descriptions from all associated GenBank mRNAs


	Z35227 - H.sapiens TTF mRNA for small G protein. BC014261 - Homo sapiens ras homolog gene family, member H, mRNA (cDNA clone MGC:20656 IMAGE:4763104), complete cds. AK313744 - Homo sapiens cDNA, FLJ94345, Homo sapiens ras homolog gene family, member H (ARHH), mRNA. JD290234 - Sequence 271258 from Patent EP1572962. JD146978 - Sequence 128002 from Patent EP1572962. AY673956 - Homo sapiens hematopoiesis-specific RhoH (RHOH) mRNA, exon X4 and 5' UTR. JD040549 - Sequence 21573 from Patent EP1572962. JD065374 - Sequence 46398 from Patent EP1572962. JD557635 - Sequence 538659 from Patent EP1572962. JD038345 - Sequence 19369 from Patent EP1572962. JD144900 - Sequence 125924 from Patent EP1572962. CU676949 - Synthetic construct Homo sapiens gateway clone IMAGE:100017556 5' read RHOH mRNA. AB464685 - Synthetic construct DNA, clone: pF1KB9787, Homo sapiens RHOH gene for ras homolog gene family, member H, without stop codon, in Flexi system. CR450349 - Homo sapiens full open reading frame cDNA clone RZPDo834G112D for gene ARHH, ras homolog gene family, member H; complete cds; without stopcodon. DQ895867 - Synthetic construct Homo sapiens clone IMAGE:100010327; FLH188447.01L; RZPDo839C0663D ras homolog gene family, member H (RHOH) gene, encodes complete protein. DQ892629 - Synthetic construct clone IMAGE:100005259; FLH188451.01X; RZPDo839C0673D ras homolog gene family, member H (RHOH) gene, encodes complete protein. KJ890709 - Synthetic construct Homo sapiens clone ccsbBroadEn_00103 RHOH gene, encodes complete protein. AF498975 - Homo sapiens small GTP binding protein RhoH (ARHH) mRNA, complete cds. JD360778 - Sequence 341802 from Patent EP1572962. JD314054 - Sequence 295078 from Patent EP1572962. JD278749 - Sequence 259773 from Patent EP1572962. JD445545 - Sequence 426569 from Patent EP1572962. JD445546 - Sequence 426570 from Patent EP1572962. JD501579 - Sequence 482603 from Patent EP1572962. JD293175 - Sequence 274199 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A024R9S8, ARHH , ENST00000381799.1, ENST00000381799.2, ENST00000381799.3, ENST00000381799.4, ENST00000381799.5, ENST00000381799.6, ENST00000381799.7, ENST00000381799.8, ENST00000381799.9, hCG_37394 , NM_004310, Q6ICP4, Q6ICP4_HUMAN, RHOH , uc318qmb.1, uc318qmb.2 UCSC ID: ENST00000381799.10_4 RefSeq Accession: NM_004310.5 Protein: Q6ICP4

Gene Model Information


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Methods, Credits, and Use Restrictions


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