ID:RGS9_HUMAN DESCRIPTION: RecName: Full=Regulator of G-protein signaling 9; Short=RGS9; FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(t)-alpha. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity). SUBUNIT: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5. Component of the RGS9-1-Gbeta5 complex composed of isoform 3 of RGS9 (RGS9-1), Gbeta5 (GNB5) and RGS9BP (Probable). SUBCELLULAR LOCATION: Isoform 3: Membrane; Peripheral membrane protein. Note=Isoform 3 is targeted to the membrane via its interaction with RGS9BP (By similarity). TISSUE SPECIFICITY: Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors). DOMAIN: In photoreceptor cells the DEP domain is essential for targeting RGS9 to the outer rod segments. PTM: Retinal isoform 3 is light-dependent phosphorylated at 'Ser- 478'. Phosphorylation is decreased by light exposition (By similarity). DISEASE: Defects in RGS9 are a cause of prolonged electroretinal response suppression (PERRS) [MIM:608415]; also known as bradyopsia. PERRS is characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. SIMILARITY: Contains 1 DEP domain. SIMILARITY: Contains 1 G protein gamma domain. SIMILARITY: Contains 1 RGS domain. SEQUENCE CAUTION: Sequence=AAC25430.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00610 - Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PF00615 - Regulator of G protein signaling domain PF00631 - GGL domain PF18148 - Regulator of G-protein signalling DHEX domain
ModBase Predicted Comparative 3D Structure on O75916
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
