ID:RBM22_HUMAN DESCRIPTION: RecName: Full=Pre-mRNA-splicing factor RBM22; AltName: Full=RNA-binding motif protein 22; AltName: Full=Zinc finger CCCH domain-containing protein 16; FUNCTION: Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. SUBUNIT: Identified in the spliceosome C complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm. INTERACTION: P04156:PRNP; NbExp=1; IntAct=EBI-2602260, EBI-977302; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol. DOMAIN: The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding (By similarity). SIMILARITY: Belongs to the SLT11 family. SIMILARITY: Contains 1 C3H1-type zinc finger. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SEQUENCE CAUTION: Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NW64
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000060 protein import into nucleus, translocation GO:0000387 spliceosomal snRNP assembly GO:0000398 mRNA splicing, via spliceosome GO:0006397 mRNA processing GO:0008380 RNA splicing GO:0033120 positive regulation of RNA splicing GO:0035690 cellular response to drug GO:0042307 positive regulation of protein import into nucleus GO:0045292 mRNA cis splicing, via spliceosome GO:0046827 positive regulation of protein export from nucleus
AL136933 - Homo sapiens mRNA; cDNA DKFZp586I1822 (from clone DKFZp586I1822). BC003402 - Homo sapiens RNA binding motif protein 22, mRNA (cDNA clone MGC:4943 IMAGE:3449258), complete cds. AK001152 - Homo sapiens cDNA FLJ10290 fis, clone MAMMA1002385, weakly similar to RIBONUCLEOPROTEIN RB97D. AK297019 - Homo sapiens cDNA FLJ55715 complete cds, highly similar to Homo sapiens RNA binding motif protein 22 (RBM22), mRNA. AB463237 - Synthetic construct DNA, clone: pF1KB8661, Homo sapiens RBM22 gene for RNA binding motif protein 22, without stop codon, in Flexi system. AM393639 - Synthetic construct Homo sapiens clone IMAGE:100001690 for hypothetical protein (RBM22 gene). AK096728 - Homo sapiens cDNA FLJ39409 fis, clone PLACE6013883. JD419211 - Sequence 400235 from Patent EP1572962. JD433946 - Sequence 414970 from Patent EP1572962. JD356866 - Sequence 337890 from Patent EP1572962. JD354915 - Sequence 335939 from Patent EP1572962. U39402 - Human fetal brain (199G4) mRNA, complete cds. JD160669 - Sequence 141693 from Patent EP1572962. JD296489 - Sequence 277513 from Patent EP1572962. JD333460 - Sequence 314484 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NW64 (Reactome details) participates in the following event(s):
R-HSA-72127 Formation of the Spliceosomal B Complex R-HSA-72143 Lariat Formation and 5'-Splice Site Cleavage R-HSA-72139 Formation of the active Spliceosomal C (B*) complex R-HSA-72130 Formation of an intermediate Spliceosomal C (Bact) complex R-HSA-156661 Formation of Exon Junction Complex R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72172 mRNA Splicing R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA R-HSA-8953854 Metabolism of RNA
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
