Human Gene RABL2A (ENST00000683472.1_4) from GENCODE V47lift37

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Description: RAB, member of RAS oncogene family like 2A, transcript variant 25 (from RefSeq NM_001354427.2)
Gencode Transcript: ENST00000683472.1_4
Gencode Gene: ENSG00000144134.19_13
Transcript (Including UTRs)
Position: hg19 chr2:114,384,843-114,400,969 Size: 16,127 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr2:114,386,184-114,399,706 Size: 13,523 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:114,384,843-114,400,969)			mRNA (may differ from genome)		Protein (229 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RBL2A_HUMAN DESCRIPTION: RecName: Full=Rab-like protein 2A; SIMILARITY: Belongs to the small GTPase superfamily. Rab family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D001564 Benzo(a)pyrene D019256 Cadmium Chloride D006861 Hydrogen Peroxide D008748 Methylcholanthrene D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C017947 sodium arsenite

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-73.00	188	-0.388	Picture	PostScript	Text
3' UTR	-382.60	1263	-0.303	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9UBK7


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding

Descriptions from all associated GenBank mRNAs


	BC111008 - Homo sapiens RAB, member of RAS oncogene family-like 2A, mRNA (cDNA clone MGC:117180 IMAGE:5769737), complete cds. AK289496 - Homo sapiens cDNA FLJ78724 complete cds, highly similar to Homo sapiens RAB, member of RAS oncogene family-like 2B (RABL2B), transcript variant 1, mRNA. JD211753 - Sequence 192777 from Patent EP1572962. AF095350 - Homo sapiens RAB-like protein 2A (RABL2A) mRNA, complete cds. AF095351 - Homo sapiens RAB-like protein 2A (RABL2A) mRNA, complete cds. JD137727 - Sequence 118751 from Patent EP1572962. BC126129 - Homo sapiens RAB, member of RAS oncogene family-like 2A, mRNA (cDNA clone MGC:161407 IMAGE:8991845), complete cds. BC144050 - Homo sapiens RAB, member of RAS oncogene family-like 2A, mRNA (cDNA clone MGC:177587 IMAGE:9052570), complete cds. BC144052 - Homo sapiens RAB, member of RAS oncogene family-like 2A, mRNA (cDNA clone MGC:177589 IMAGE:9052572), complete cds. CR456554 - Homo sapiens RABL2B full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.RABL2B.V2). JD049902 - Sequence 30926 from Patent EP1572962. JD132799 - Sequence 113823 from Patent EP1572962. BC062578 - Homo sapiens cDNA clone IMAGE:5198566, partial cds. HQ258363 - Synthetic construct Homo sapiens clone IMAGE:100072792 Unknown protein gene, encodes complete protein. KJ902211 - Synthetic construct Homo sapiens clone ccsbBroadEn_11605 RABL2A gene, encodes complete protein. AB528220 - Synthetic construct DNA, clone: pF1KE0538, Homo sapiens RABL2A gene for RAB, member of RAS oncogene family-like 2A, without stop codon, in Flexi system. CU013442 - Homo sapiens RABL2B, mRNA (cDNA clone IMAGE:100000411), complete cds, without stop codon, in Gateway system. KJ902212 - Synthetic construct Homo sapiens clone ccsbBroadEn_11606 RABL2A gene, encodes complete protein. CU013154 - Homo sapiens RABL2B, mRNA (cDNA clone IMAGE:100000507), complete cds, with stop codon, in Gateway system. DQ581316 - Homo sapiens piRNA piR-49428, complete sequence. AL137649 - Homo sapiens mRNA; cDNA DKFZp434J0713 (from clone DKFZp434J0713). AK092971 - Homo sapiens cDNA FLJ35652 fis, clone SPLEN2013673, moderately similar to Homo sapiens RAB-like protein 2A (RABL2A) mRNA. AX747831 - Sequence 1356 from Patent EP1308459. JD554006 - Sequence 535030 from Patent EP1572962. JD418718 - Sequence 399742 from Patent EP1572962. JD417899 - Sequence 398923 from Patent EP1572962. JD253609 - Sequence 234633 from Patent EP1572962. JD365511 - Sequence 346535 from Patent EP1572962. JD451621 - Sequence 432645 from Patent EP1572962. JD206769 - Sequence 187793 from Patent EP1572962. JD301269 - Sequence 282293 from Patent EP1572962. JD386105 - Sequence 367129 from Patent EP1572962. JD549893 - Sequence 530917 from Patent EP1572962. JD266127 - Sequence 247151 from Patent EP1572962. JD523607 - Sequence 504631 from Patent EP1572962. JD523606 - Sequence 504630 from Patent EP1572962. JD140629 - Sequence 121653 from Patent EP1572962. JD140628 - Sequence 121652 from Patent EP1572962. JD140627 - Sequence 121651 from Patent EP1572962. JD198441 - Sequence 179465 from Patent EP1572962. JD198440 - Sequence 179464 from Patent EP1572962. JD559320 - Sequence 540344 from Patent EP1572962. JD198439 - Sequence 179463 from Patent EP1572962. JD272061 - Sequence 253085 from Patent EP1572962. JD198438 - Sequence 179462 from Patent EP1572962. JD153215 - Sequence 134239 from Patent EP1572962. JD153216 - Sequence 134240 from Patent EP1572962. JD153217 - Sequence 134241 from Patent EP1572962. JD247459 - Sequence 228483 from Patent EP1572962. JD325923 - Sequence 306947 from Patent EP1572962. JD367232 - Sequence 348256 from Patent EP1572962. JD527699 - Sequence 508723 from Patent EP1572962. JD527702 - Sequence 508726 from Patent EP1572962. JD294984 - Sequence 276008 from Patent EP1572962. JD527705 - Sequence 508729 from Patent EP1572962. JD488413 - Sequence 469437 from Patent EP1572962. JD527704 - Sequence 508728 from Patent EP1572962. JD546050 - Sequence 527074 from Patent EP1572962. JD527703 - Sequence 508727 from Patent EP1572962. JD227558 - Sequence 208582 from Patent EP1572962. JD228613 - Sequence 209637 from Patent EP1572962. JD258873 - Sequence 239897 from Patent EP1572962. JD407766 - Sequence 388790 from Patent EP1572962. JD479040 - Sequence 460064 from Patent EP1572962. JD519890 - Sequence 500914 from Patent EP1572962. JD135566 - Sequence 116590 from Patent EP1572962. JD165738 - Sequence 146762 from Patent EP1572962. JD409250 - Sequence 390274 from Patent EP1572962. JD488996 - Sequence 470020 from Patent EP1572962. JD488997 - Sequence 470021 from Patent EP1572962. JD396146 - Sequence 377170 from Patent EP1572962. JD426708 - Sequence 407732 from Patent EP1572962. JD128221 - Sequence 109245 from Patent EP1572962. JD074124 - Sequence 55148 from Patent EP1572962. JD488169 - Sequence 469193 from Patent EP1572962. JD114397 - Sequence 95421 from Patent EP1572962. JD261458 - Sequence 242482 from Patent EP1572962. JD038669 - Sequence 19693 from Patent EP1572962. JD317824 - Sequence 298848 from Patent EP1572962. JD378855 - Sequence 359879 from Patent EP1572962. JD504365 - Sequence 485389 from Patent EP1572962. JD046727 - Sequence 27751 from Patent EP1572962. JD403558 - Sequence 384582 from Patent EP1572962. JD460433 - Sequence 441457 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B7ZBD6, NM_001354427, Q9NU37, Q9UBK7, RBL2A_HUMAN, uc330lli.1, uc330lli.2 UCSC ID: ENST00000683472.1_4 RefSeq Accession: NM_001306158.2 Protein: Q9UBK7 (aka RBL2A_HUMAN or RBLA_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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