Human Gene RAB44 (ENST00000612677.6_5) from GENCODE V47lift37
  Description: RAB44, member RAS oncogene family (from RefSeq NM_001257357.2)
Gencode Transcript: ENST00000612677.6_5
Gencode Gene: ENSG00000255587.9_8
Transcript (Including UTRs)
   Position: hg19 chr6:36,665,603-36,700,961 Size: 35,359 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr6:36,672,013-36,699,870 Size: 27,858 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:36,665,603-36,700,961)mRNA (may differ from genome)Protein (1021 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedReactomeUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RAB44_HUMAN
DESCRIPTION: RecName: Full=Ras-related protein Rab-44;
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
SEQUENCE CAUTION: Sequence=CAD92808.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.40102-0.376 Picture PostScript Text
3' UTR -382.601091-0.351 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005225 - Small_GTP-bd_dom
IPR001806 - Small_GTPase
IPR003579 - Small_GTPase_Rab_type

Pfam Domains:
PF00025 - ADP-ribosylation factor family
PF00071 - Ras family
PF01926 - 50S ribosome-binding GTPase
PF04670 - Gtr1/RagA G protein conserved region
PF08477 - Ras of Complex, Roc, domain of DAPkinase
PF13833 - EF-hand domain pair

SCOP Domains:
47473 - EF-hand
52540 - P-loop containing nucleoside triphosphate hydrolases
58069 - Virus ectodomain

ModBase Predicted Comparative 3D Structure on Q7Z6P3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005525 GTP binding

Biological Process:
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0035577 azurophil granule membrane
GO:0035579 specific granule membrane


-  Descriptions from all associated GenBank mRNAs
  AK125083 - Homo sapiens cDNA FLJ43093 fis, clone CORDB1000140.
JD026483 - Sequence 7507 from Patent EP1572962.
JD030542 - Sequence 11566 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z6P3 (Reactome details) participates in the following event(s):

R-HSA-6798739 Exocytosis of azurophil granule membrane proteins
R-HSA-6799350 Exocytosis of specific granule membrane proteins
R-HSA-8870466 RGGT:CHM binds RABs
R-HSA-8870469 RGGT geranylgeranylates RAB proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-8873719 RAB geranylgeranylation
R-HSA-168256 Immune System
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087WXI0, ENST00000612677.1, ENST00000612677.2, ENST00000612677.3, ENST00000612677.4, ENST00000612677.5, NM_001257357, Q7Z6P3, RAB44_HUMAN, uc327odr.1, uc327odr.2
UCSC ID: ENST00000612677.6_5
RefSeq Accession: NM_001257357.2
Protein: Q7Z6P3 (aka RAB44_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.