ID:PTTG_HUMAN DESCRIPTION: RecName: Full=Pituitary tumor-transforming gene 1 protein-interacting protein; AltName: Full=Pituitary tumor-transforming gene protein-binding factor; Short=PBF; Short=PTTG-binding factor; Flags: Precursor; FUNCTION: May facilitate PTTG1 nuclear translocation. SUBUNIT: Interacts with PTTG1. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Nucleus. Note=According to PubMed:10781616, it is found in the cytoplasm and the nucleus. TISSUE SPECIFICITY: Ubiquitous. INDUCTION: By transcription factor RUNX2. SIMILARITY: Contains 1 PSI domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PTTG1IPID41944ch21q22.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P53801
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006606 protein import into nucleus GO:0031398 positive regulation of protein ubiquitination GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1903364 positive regulation of cellular protein catabolic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
