Human Gene PTP4A3 (ENST00000521578.6_4) from GENCODE V47lift37
  Description: protein tyrosine phosphatase 4A3, transcript variant 1 (from RefSeq NM_032611.3)
Gencode Transcript: ENST00000521578.6_4
Gencode Gene: ENSG00000184489.13_11
Transcript (Including UTRs)
   Position: hg19 chr8:142,402,121-142,442,554 Size: 40,434 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr8:142,432,341-142,441,144 Size: 8,804 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:142,402,121-142,442,554)mRNA (may differ from genome)Protein (173 aa)
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-  Comments and Description Text from UniProtKB
  ID: TP4A3_HUMAN
DESCRIPTION: RecName: Full=Protein tyrosine phosphatase type IVA 3; EC=3.1.3.48; AltName: Full=PRL-R; AltName: Full=Protein-tyrosine phosphatase 4a3; AltName: Full=Protein-tyrosine phosphatase of regenerating liver 3; Short=PRL-3; Flags: Precursor;
FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
ENZYME REGULATION: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine.
SUBUNIT: Interacts with tubulin.
SUBCELLULAR LOCATION: Cell membrane. Early endosome.
TISSUE SPECIFICITY: Mainly expressed in cardiomyocytes and skeletal muscle; also found in pancreas. Consistently overexpressed in colon cancer metastasis.
PTM: Farnesylated. Farnesylation is required for membrane targeting (By similarity).
SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: PTP4A3
Diseases sorted by gene-association score: uveal melanoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 205.55 RPKM in Heart - Left Ventricle
Total median expression: 1836.98 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -393.20917-0.429 Picture PostScript Text
3' UTR -723.101410-0.513 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000387 - Tyr/Dual-specificity_Pase
IPR000242 - Tyr_Pase_rcpt/non-rcpt

Pfam Domains:
PF00102 - Protein-tyrosine phosphatase

SCOP Domains:
52799 - (Phosphotyrosine protein) phosphatases II

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1R6H - NMR MuPIT 1V3A - NMR MuPIT


ModBase Predicted Comparative 3D Structure on O75365
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0004727 prenylated protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity

Biological Process:
GO:0006355 regulation of transcription, DNA-templated
GO:0006470 protein dephosphorylation
GO:0007219 Notch signaling pathway
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0043117 positive regulation of vascular permeability
GO:0043542 endothelial cell migration
GO:1900746 regulation of vascular endothelial growth factor signaling pathway
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1904951 positive regulation of establishment of protein localization
GO:1990830 cellular response to leukemia inhibitory factor

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AK311257 - Homo sapiens cDNA, FLJ18299.
BC003105 - Homo sapiens protein tyrosine phosphatase type IVA, member 3, mRNA (cDNA clone MGC:1950 IMAGE:3357244), complete cds.
AF041434 - Homo sapiens potentially prenylated protein tyrosine phosphatase hPRL-3 mRNA, complete cds.
AJ276554 - Homo sapiens mRNA for protein tyrosine phosphatase hPRL-3, short form.
JD353222 - Sequence 334246 from Patent EP1572962.
JD106190 - Sequence 87214 from Patent EP1572962.
JD195427 - Sequence 176451 from Patent EP1572962.
AB590741 - Synthetic construct DNA, clone: pFN21AE1656, Homo sapiens PTP4A3 gene for protein tyrosine phosphatase type IVA, member 3, without stop codon, in Flexi system.
KJ893238 - Synthetic construct Homo sapiens clone ccsbBroadEn_02632 PTP4A3 gene, encodes complete protein.
BT007303 - Homo sapiens protein tyrosine phosphatase type IVA, member 3 mRNA, complete cds.
U87168 - Human protein tyrosine phosphatase homolog hPRL-R mRNA, partial cds.
AK128380 - Homo sapiens cDNA FLJ46523 fis, clone THYMU3034099.
AY819648 - Homo sapiens HCV p7-transregulated protein 2 mRNA, complete cds.
JD280428 - Sequence 261452 from Patent EP1572962.
JD099544 - Sequence 80568 from Patent EP1572962.
JD425690 - Sequence 406714 from Patent EP1572962.
JD427080 - Sequence 408104 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000521578.1, ENST00000521578.2, ENST00000521578.3, ENST00000521578.4, ENST00000521578.5, NM_032611, O75365, PRL3, Q8IVN5, Q99849, Q9BTW5, TP4A3_HUMAN, uc323vgh.1, uc323vgh.2
UCSC ID: ENST00000521578.6_4
RefSeq Accession: NM_032611.3
Protein: O75365 (aka TP4A3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.