Human Gene PTER (ENST00000535784.7_5) from GENCODE V47lift37

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Description: phosphotriesterase related, transcript variant 2 (from RefSeq NM_030664.5)
Gencode Transcript: ENST00000535784.7_5
Gencode Gene: ENSG00000165983.15_8
Transcript (Including UTRs)
Position: hg19 chr10:16,479,009-16,555,744 Size: 76,736 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr10:16,526,384-16,553,255 Size: 26,872 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:16,479,009-16,555,744)			mRNA (may differ from genome)		Protein (349 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: PTER_HUMAN DESCRIPTION: RecName: Full=Phosphotriesterase-related protein; EC=3.1.-.-; AltName: Full=Parathion hydrolase-related protein; Short=hPHRP; COFACTOR: Binds 2 divalent metal cations per subunit (By similarity). SIMILARITY: Belongs to the phosphotriesterase family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PTER Diseases sorted by gene-association score: chromosome 16p13.3 duplication syndrome (4), spinocerebellar ataxia type 16 (3), potocki-luspski syndrome (2), nodular tenosynovitis (2), chromosomal deletion syndrome (2), chromosome 18p deletion syndrome (2), bartholin's gland benign neoplasm (2), holoprosencephaly 4 (2), chromosomal disease (2), chromosome xp21 deletion syndrome (2), rieger syndrome, type 2 (2), chromosome 5p13 duplication syndrome (2), congenital nervous system abnormality (1), specific developmental disorder (1), non-gestational choriocarcinoma (1), physical disorder (1), diaphragmatic eventration (1), hereditary wilms' tumor (1), chromosome 3q29 microdeletion syndrome (1), pineal parenchymal tumor of intermediate differentiation (1), aland island eye disease (1), fibrosarcoma of bone (1), acute contagious conjunctivitis (1), malignant fibrous histiocytoma of bone (1), hypoparathyroidism-deafness-renal disease syndrome (1), trichorhinophalangeal syndrome, type i (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene C006253 pirinixic acid C029141 2,2,5,7,8-pentamethyl-1-hydroxychroman C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C035207 4-amino-2,6-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D000643 Ammonium Chloride D019327 Copper Sulfate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.98 RPKM in Brain - Anterior cingulate cortex (BA24) Total median expression: 203.97 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-18.60	86	-0.216	Picture	PostScript	Text
3' UTR	-530.40	2489	-0.213	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR017947 - AryldialkylPase_Zn-BS
IPR001559 - Aryldialkylphosphatase

Pfam Domains:
PF01026 - TatD related DNase
PF02126 - Phosphotriesterase family

SCOP Domains:
51569 - Aldolase
51395 - FMN-linked oxidoreductases
51556 - Metallo-dependent hydrolases
53383 - PLP-dependent transferases

ModBase Predicted Comparative 3D Structure on Q96BW5


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details		Gene Details
Gene Sorter	Gene Sorter		Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003674 molecular_function GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016788 hydrolase activity, acting on ester bonds GO:0046872 metal ion binding Biological Process: GO:0009056 catabolic process GO:0030855 epithelial cell differentiation Cellular Component: GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	AK314910 - Homo sapiens cDNA, FLJ95816, Homo sapiens phosphotriesterase related (PTER), mRNA. BC015092 - Homo sapiens phosphotriesterase related, mRNA (cDNA clone MGC:22656 IMAGE:4049884), complete cds. BC050411 - Homo sapiens phosphotriesterase related, mRNA (cDNA clone MGC:54070 IMAGE:6472327), complete cds. BX648556 - Homo sapiens mRNA; cDNA DKFZp779I2035 (from clone DKFZp779I2035). AK095486 - Homo sapiens cDNA FLJ38167 fis, clone DFNES2007113, highly similar to Phosphotriesterase-related protein. AF212237 - Homo sapiens HPHRP mRNA, complete cds. JD376904 - Sequence 357928 from Patent EP1572962. JD111038 - Sequence 92062 from Patent EP1572962. CU677211 - Synthetic construct Homo sapiens gateway clone IMAGE:100023411 5' read PTER mRNA. CU690666 - Synthetic construct Homo sapiens gateway clone IMAGE:100021397 5' read PTER mRNA. KJ905995 - Synthetic construct Homo sapiens clone ccsbBroadEn_15665 PTER gene, encodes complete protein. HQ448592 - Synthetic construct Homo sapiens clone IMAGE:100072030; CCSB011558_01 phosphotriesterase related (PTER) gene, encodes complete protein. KJ892741 - Synthetic construct Homo sapiens clone ccsbBroadEn_02135 PTER gene, encodes complete protein. JD162173 - Sequence 143197 from Patent EP1572962. JD435247 - Sequence 416271 from Patent EP1572962. JD420794 - Sequence 401818 from Patent EP1572962. JD280969 - Sequence 261993 from Patent EP1572962. JD555188 - Sequence 536212 from Patent EP1572962. JD303831 - Sequence 284855 from Patent EP1572962. JD104629 - Sequence 85653 from Patent EP1572962. JD502264 - Sequence 483288 from Patent EP1572962. JD360537 - Sequence 341561 from Patent EP1572962. JD431347 - Sequence 412371 from Patent EP1572962. JD539131 - Sequence 520155 from Patent EP1572962. JD503302 - Sequence 484326 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B0YJ77, B3KTF5, D3DRU0, ENST00000535784.1, ENST00000535784.2, ENST00000535784.3, ENST00000535784.4, ENST00000535784.5, ENST00000535784.6, NM_030664, PTER_HUMAN, Q96BW5, Q9BY46, uc324ogh.1, uc324ogh.2 UCSC ID: ENST00000535784.7_5 RefSeq Accession: NM_001261836.2 Protein: Q96BW5 (aka PTER_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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