Human Gene PPIP5K1 (ENST00000420765.6_7) from GENCODE V48lift37

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Description: diphosphoinositol pentakisphosphate kinase 1, transcript variant 32 (from RefSeq NM_001394395.1)
Gencode Transcript: ENST00000420765.6_7
Gencode Gene: ENSG00000168781.24_21
Transcript (Including UTRs)
Position: hg19 chr15:43,825,673-43,882,406 Size: 56,734 Total Exon Count: 32 Strand: -
Coding Region
Position: hg19 chr15:43,826,872-43,876,702 Size: 49,831 Coding Exon Count: 30

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Pathways	Other Names
Model Information	Methods

Data last updated at UCSC: 2025-04-10 15:10:12

Sequence and Links to Tools and Databases

Genomic Sequence (chr15:43,825,673-43,882,406)			mRNA (may differ from genome)		Protein (1490 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
MGI	PubMed	UniProtKB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C547126 AZM551248 D016604 Aflatoxin B1 D002251 Carbon Tetrachloride D016572 Cyclosporine D004052 Diethylnitrosamine C016517 indole-3-carbinol D020122 tert-Butylhydroperoxide C009495 titanium dioxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 25.57 RPKM in Brain - Cerebellum Total median expression: 220.91 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-61.50	159	-0.387	Picture	PostScript	Text
3' UTR	-389.50	1199	-0.325	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	KJ902008 - Synthetic construct Homo sapiens clone ccsbBroadEn_11402 PPIP5K1 gene, encodes complete protein. LF205858 - JP 2014500723-A/13361: Polycomb-Associated Non-Coding RNAs. BX647870 - Homo sapiens mRNA; cDNA DKFZp313L0221 (from clone DKFZp313L0221). BC035611 - Homo sapiens Histidine acid phosphatase domain containing 2A, mRNA (cDNA clone IMAGE:3865623). BC057395 - Homo sapiens histidine acid phosphatase domain containing 2A, mRNA (cDNA clone MGC:60345 IMAGE:6142663), complete cds. BX538022 - Homo sapiens mRNA; cDNA DKFZp686I0669 (from clone DKFZp686I0669). BX647814 - Homo sapiens mRNA; cDNA DKFZp686O2251 (from clone DKFZp686O2251). JD266864 - Sequence 247888 from Patent EP1572962. AB002375 - Homo sapiens mRNA for KIAA0377 gene. JD049049 - Sequence 30073 from Patent EP1572962. JD343456 - Sequence 324480 from Patent EP1572962. JD429665 - Sequence 410689 from Patent EP1572962. JD093629 - Sequence 74653 from Patent EP1572962. JD295311 - Sequence 276335 from Patent EP1572962. JD480826 - Sequence 461850 from Patent EP1572962. AF543190 - Homo sapiens KIAA0377 splice variant 4 mRNA, complete cds; alternatively spliced. AF502586 - Homo sapiens KIAA0377 splice variant 1 mRNA, complete cds, alternatively spliced. AF502588 - Homo sapiens KIAA0377 splice variant 3 mRNA, complete cds, alternatively spliced. AF502589 - Homo sapiens KIAA0377 splice variant 4 mRNA, complete cds, alternatively spliced. JD074252 - Sequence 55276 from Patent EP1572962. JD249114 - Sequence 230138 from Patent EP1572962. JD249113 - Sequence 230137 from Patent EP1572962. JD302668 - Sequence 283692 from Patent EP1572962. JD131871 - Sequence 112895 from Patent EP1572962. JD386281 - Sequence 367305 from Patent EP1572962. AF502587 - Homo sapiens KIAA0377 splice variant 2 mRNA, complete cds, alternatively spliced. JD305332 - Sequence 286356 from Patent EP1572962. JD404446 - Sequence 385470 from Patent EP1572962. JD489783 - Sequence 470807 from Patent EP1572962. JD282031 - Sequence 263055 from Patent EP1572962. JD162348 - Sequence 143372 from Patent EP1572962. JD323275 - Sequence 304299 from Patent EP1572962. JD196785 - Sequence 177809 from Patent EP1572962. JD486698 - Sequence 467722 from Patent EP1572962. JD064991 - Sequence 46015 from Patent EP1572962. JD086616 - Sequence 67640 from Patent EP1572962. JD486815 - Sequence 467839 from Patent EP1572962. AB385319 - Synthetic construct DNA, clone: pF1KA0377, Homo sapiens HISPPD2A gene for histidine acid phosphatase domain-containing protein 2A isoform 2, complete cds, without stop codon, in Flexi system. DQ102768 - Homo sapiens unknown mRNA, alternatively spliced. AK307438 - Homo sapiens cDNA, FLJ97386. MA441435 - JP 2018138019-A/13361: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-6369 - inositol diphosphates biosynthesis PWY-6371 - superpathway of inositol phosphate compounds

Other Names for This Gene


	Alternate Gene Symbols: A0A8J8ZH50, A0A8J8ZH50_HUMAN, ENST00000420765.1, ENST00000420765.2, ENST00000420765.3, ENST00000420765.4, ENST00000420765.5, NM_001394395, PPIP5K1 , uc319qfm.1, uc319qfm.2 UCSC ID: ENST00000420765.6_7 RefSeq Accession: NM_001394395.1

Gene Model Information


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Methods, Credits, and Use Restrictions


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