Human Gene PPBP (ENST00000296028.4_8) from GENCODE V47lift37

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Description: pro-platelet basic protein (from RefSeq NM_002704.3)
Gencode Transcript: ENST00000296028.4_8
Gencode Gene: ENSG00000163736.5_11
Transcript (Including UTRs)
Position: hg19 chr4:74,852,156-74,853,907 Size: 1,752 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr4:74,852,989-74,853,820 Size: 832 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr4:74,852,156-74,853,907)			mRNA (may differ from genome)		Protein (128 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: CXCL7_HUMAN DESCRIPTION: RecName: Full=Platelet basic protein; Short=PBP; AltName: Full=C-X-C motif chemokine 7; AltName: Full=Leukocyte-derived growth factor; Short=LDGF; AltName: Full=Macrophage-derived growth factor; Short=MDGF; AltName: Full=Small-inducible cytokine B7; Contains: RecName: Full=Connective tissue-activating peptide III; Short=CTAP-III; AltName: Full=LA-PF4; AltName: Full=Low-affinity platelet factor IV; Contains: RecName: Full=TC-2; Contains: RecName: Full=Connective tissue-activating peptide III(1-81); Short=CTAP-III(1-81); Contains: RecName: Full=Beta-thromboglobulin; Short=Beta-TG; Contains: RecName: Full=Neutrophil-activating peptide 2(74); Short=NAP-2(74); Contains: RecName: Full=Neutrophil-activating peptide 2(73); Short=NAP-2(73); Contains: RecName: Full=Neutrophil-activating peptide 2; Short=NAP-2; Contains: RecName: Full=TC-1; Contains: RecName: Full=Neutrophil-activating peptide 2(1-66); Short=NAP-2(1-66); Contains: RecName: Full=Neutrophil-activating peptide 2(1-63); Short=NAP-2(1-63); Flags: Precursor; FUNCTION: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. SUBUNIT: Beta-thromboglobulin is a homotetramer. SUBCELLULAR LOCATION: Secreted. PTM: Proteolytic removal of residues 1-9 produces the active peptide connective tissue-activating peptide III (CTAP-III) (low- affinity platelet factor IV (LA-PF4)). PTM: Proteolytic removal of residues 1-13 produces the active peptide beta-thromboglobulin, which is released from platelets along with platelet factor 4 and platelet-derived growth factor. PTM: NAP-2(1-66) is produced by proteolytical processing, probably after secretion by leukocytes other than neutrophils. PTM: NAP-2(73) and NAP-2(74) seem not be produced by proteolytical processing of secreted precursors but are released in an active form from platelets. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=CXCL7 entry; URL="http://en.wikipedia.org/wiki/CXCL7";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: PPBP Diseases sorted by gene-association score: erythromelalgia (8), essential thrombocythemia (5), colloid adenoma (4), peripheral vascular disease (4), atrial fibrillation (3), hemorrhagic disease (3), asthma (2), vascular disease (2), migraine with or without aura 1 (2), hypertension, essential (2), myocardial infarction (2), stroke, ischemic (2), listeria meningitis (1), thrombotic thrombocytopenic purpura, acquired (0)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D015112 4-Nitroquinoline-1-oxide D000082 Acetaminophen D000244 Adenosine Diphosphate D000535 Aluminum D017311 Amlodipine D000643 Ammonium Chloride D001151 Arsenic D001241 Aspirin D001554 Benzene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 46.84 RPKM in Whole Blood Total median expression: 85.75 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-15.70	87	-0.180	Picture	PostScript	Text
3' UTR	-146.70	833	-0.176	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001089 - Chemokine_CXC
IPR018048 - Chemokine_CXC_CS
IPR002473 - Chemokine_CXCL8/IL8
IPR001811 - Chemokine_IL8-like_dom

Pfam Domains:
PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like

SCOP Domains:
54117 - Interleukin 8-like chemokines

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1F9P - X-ray

1NAP - X-ray MuPIT

1TVX - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P02775


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005125 cytokine activity GO:0005355 glucose transmembrane transporter activity GO:0008009 chemokine activity GO:0008083 growth factor activity GO:0045236 CXCR chemokine receptor binding Biological Process: GO:0002576 platelet degranulation GO:0006935 chemotaxis GO:0006952 defense response GO:0006954 inflammatory response GO:0006955 immune response GO:0007186 G-protein coupled receptor signaling pathway GO:0010469 regulation of receptor activity GO:0031640 killing of cells of other organism GO:0032496 response to lipopolysaccharide GO:0042127 regulation of cell proliferation GO:0042742 defense response to bacterium GO:0043312 neutrophil degranulation GO:0051781 positive regulation of cell division GO:0060326 cell chemotaxis GO:0070098 chemokine-mediated signaling pathway GO:0090023 positive regulation of neutrophil chemotaxis GO:1904659 glucose transmembrane transport Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:1904724 tertiary granule lumen

Descriptions from all associated GenBank mRNAs


	KJ891856 - Synthetic construct Homo sapiens clone ccsbBroadEn_01250 PPBP gene, encodes complete protein. BC028217 - Homo sapiens pro-platelet basic protein (chemokine (C-X-C motif) ligand 7), mRNA (cDNA clone MGC:40008 IMAGE:5214257), complete cds. M54995 - Human connective tissue activation peptide III mRNA, complete cds. JD549288 - Sequence 530312 from Patent EP1572962. CR456805 - Homo sapiens full open reading frame cDNA clone RZPDo834A1015D for gene PPBP, pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); complete cds, incl. stopcodon. AK312166 - Homo sapiens cDNA, FLJ92452, Homo sapiens pro-platelet basic protein (chemokine (C-X-C motif)ligand 7) (PPBP), mRNA. DQ891020 - Synthetic construct clone IMAGE:100003650; FLH168582.01X; RZPDo839A1294D pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (PPBP) gene, encodes complete protein. DQ894200 - Synthetic construct Homo sapiens clone IMAGE:100008660; FLH168578.01L; RZPDo839A1293D pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) (PPBP) gene, encodes complete protein. AB464075 - Synthetic construct DNA, clone: pF1KB6702, Homo sapiens PPBP gene for pro-platelet basic protein, without stop codon, in Flexi system. JD422839 - Sequence 403863 from Patent EP1572962. JD289976 - Sequence 271000 from Patent EP1572962. JD106185 - Sequence 87209 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P02775 (Reactome details) participates in the following event(s): R-HSA-481007 Exocytosis of platelet alpha granule contents R-HSA-373813 Receptor CXCR2 binds ligands CXCL1 to 7 R-HSA-6798745 Exocytosis of tertiary granule lumen proteins R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-114608 Platelet degranulation R-HSA-380108 Chemokine receptors bind chemokines R-HSA-6798695 Neutrophil degranulation R-HSA-76005 Response to elevated platelet cytosolic Ca2+ R-HSA-418594 G alpha (i) signalling events R-HSA-375276 Peptide ligand-binding receptors R-HSA-168249 Innate Immune System R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-168256 Immune System R-HSA-109582 Hemostasis R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: B2R5F3, CTAP3, CXCL7, CXCL7_HUMAN, ENST00000296028.1, ENST00000296028.2, ENST00000296028.3, NM_002704, P02775, Q6IBJ8, SCYB7, TGB1, THBGB1, uc317lqo.1, uc317lqo.2 UCSC ID: ENST00000296028.4_8 RefSeq Accession: NM_002704.3 Protein: P02775 (aka CXCL7_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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