Human Gene PNRC2 (ENST00000334351.8_4) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: PNRC2_HUMAN
DESCRIPTION: RecName: Full=Proline-rich nuclear receptor coactivator 2;
FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure.
SUBUNIT: Interacts with UPF1/RENT1; preferentially interacts with hyperphosphorylated form. Interacts with DCP1A. Interacts with many nuclear receptors including ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR.
INTERACTION: Q92900:UPF1; NbExp=9; IntAct=EBI-726549, EBI-373471;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, P-body.
TISSUE SPECIFICITY: Expressed in heart, lung, muscle and brain.
DOMAIN: The interaction between PNRC2 and nuclear receptors is dependent on the SH3 binding motif.
SIMILARITY: Belongs to the PNRC family. PNRC2 subfamily.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR026781 - PNRC2
Pfam Domains:
PF15365 - Proline-rich nuclear receptor coactivator motif
ModBase Predicted Comparative 3D Structure on Q9NPJ4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AF151042 - Homo sapiens HSPC208 mRNA, complete cds.
AK300522 - Homo sapiens cDNA FLJ57595 complete cds, moderately similar to Proline-rich nuclear receptor coactivator 2.
BC068475 - Homo sapiens cDNA clone IMAGE:5275756, containing frame-shift errors.
AK311305 - Homo sapiens cDNA, FLJ18347.
BC001959 - Homo sapiens proline-rich nuclear receptor coactivator 2, mRNA (cDNA clone MGC:885 IMAGE:3536977), complete cds.
BC085018 - Homo sapiens proline-rich nuclear receptor coactivator 2, mRNA (cDNA clone MGC:99541 IMAGE:6650445), complete cds.
BC078177 - Homo sapiens proline-rich nuclear receptor coactivator 2, mRNA (cDNA clone MGC:87829 IMAGE:6526331), complete cds.
AF374386 - Homo sapiens proline-rich nuclear receptor coactivator 2 (PNRC2) mRNA, complete cds.
JD417297 - Sequence 398321 from Patent EP1572962.
JD228730 - Sequence 209754 from Patent EP1572962.
JD228731 - Sequence 209755 from Patent EP1572962.
JD173710 - Sequence 154734 from Patent EP1572962.
JD307600 - Sequence 288624 from Patent EP1572962.
JD422380 - Sequence 403404 from Patent EP1572962.
JD175024 - Sequence 156048 from Patent EP1572962.
JD231178 - Sequence 212202 from Patent EP1572962.
AK000319 - Homo sapiens cDNA FLJ20312 fis, clone HEP07362.
JD495216 - Sequence 476240 from Patent EP1572962.
AB464670 - Synthetic construct DNA, clone: pF1KB8741, Homo sapiens PNRC2 gene for proline-rich nuclear receptor coactivator 2, without stop codon, in Flexi system.
KJ894218 - Synthetic construct Homo sapiens clone ccsbBroadEn_03612 PNRC2 gene, encodes complete protein.
AK024774 - Homo sapiens cDNA: FLJ21121 fis, clone CAS05913.
JD376694 - Sequence 357718 from Patent EP1572962.
JD085286 - Sequence 66310 from Patent EP1572962.
JD357757 - Sequence 338781 from Patent EP1572962.
JD188457 - Sequence 169481 from Patent EP1572962.
JD280271 - Sequence 261295 from Patent EP1572962.
JD224265 - Sequence 205289 from Patent EP1572962.
JD410683 - Sequence 391707 from Patent EP1572962.
JD242379 - Sequence 223403 from Patent EP1572962.
JD114307 - Sequence 95331 from Patent EP1572962.
JD114308 - Sequence 95332 from Patent EP1572962.
JD088579 - Sequence 69603 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: B4DU72, ENST00000334351.1, ENST00000334351.2, ENST00000334351.3, ENST00000334351.4, ENST00000334351.5, ENST00000334351.6, ENST00000334351.7, HSPC208, NM_017761, PNRC2_HUMAN, Q9NPJ4, uc317txy.1, uc317txy.2
UCSC ID: ENST00000334351.8_4
RefSeq Accession: NM_017761.4
Protein: Q9NPJ4
(aka PNRC2_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
