Human Gene PLEKHF2 (ENST00000315367.4_5) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: PKHF2_HUMAN
DESCRIPTION: RecName: Full=Pleckstrin homology domain-containing family F member 2; Short=PH domain-containing family F member 2; AltName: Full=PH and FYVE domain-containing protein 2; AltName: Full=Phafin-2; AltName: Full=Zinc finger FYVE domain-containing protein 18;
INTERACTION: Q9UKJ5:CHIC2; NbExp=3; IntAct=EBI-742388, EBI-741528; Q9NS73:MBIP; NbExp=3; IntAct=EBI-742388, EBI-741953; P10644:PRKAR1A; NbExp=3; IntAct=EBI-742388, EBI-476431; Q9UI14:RABAC1; NbExp=3; IntAct=EBI-742388, EBI-712367;
SIMILARITY: Contains 1 FYVE-type zinc finger.
SIMILARITY: Contains 1 PH domain.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR000306 - Znf_FYVE
IPR017455 - Znf_FYVE-rel
IPR011011 - Znf_FYVE_PHD
IPR013083 - Znf_RING/FYVE/PHD
Pfam Domains:
PF00169 - PH domain
PF01363 - FYVE zinc finger
SCOP Domains:
50729 - PH domain-like
57903 - FYVE/PHD zinc finger
ModBase Predicted Comparative 3D Structure on Q9H8W4
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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LP895593 - Sequence 457 from Patent EP3253886.
AL834473 - Homo sapiens mRNA; cDNA DKFZp762A0711 (from clone DKFZp762A0711).
BC011806 - Homo sapiens pleckstrin homology domain containing, family F (with FYVE domain) member 2, mRNA (cDNA clone MGC:19473 IMAGE:4335031), complete cds.
AK023249 - Homo sapiens cDNA FLJ13187 fis, clone NT2RP3004242, weakly similar to PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR.
JD467129 - Sequence 448153 from Patent EP1572962.
JD458501 - Sequence 439525 from Patent EP1572962.
AB464029 - Synthetic construct DNA, clone: pF1KB7109, Homo sapiens PLEKHF2 gene for pleckstrin homology domain containing, family F (with FYVE domain) member 2, without stop codon, in Flexi system.
AM392581 - Synthetic construct Homo sapiens clone IMAGE:100002370 for hypothetical protein (PLEKHF2 gene).
AM393625 - Synthetic construct Homo sapiens clone IMAGE:100002369 for hypothetical protein (PLEKHF2 gene).
DQ896728 - Synthetic construct Homo sapiens clone IMAGE:100011188; FLH199392.01L; RZPDo839D0681D pleckstrin homology domain containing, family F (with FYVE domain) member 2 (PLEKHF2) gene, encodes complete protein.
DQ893409 - Synthetic construct clone IMAGE:100006039; FLH199486.01X; RZPDo839D0682D pleckstrin homology domain containing, family F (with FYVE domain) member 2 (PLEKHF2) gene, encodes complete protein.
KJ894710 - Synthetic construct Homo sapiens clone ccsbBroadEn_04104 PLEKHF2 gene, encodes complete protein.
AF434819 - Homo sapiens phafin 2 mRNA, complete cds.
JD265120 - Sequence 246144 from Patent EP1572962.
JD562955 - Sequence 543979 from Patent EP1572962.
JD562956 - Sequence 543980 from Patent EP1572962.
JD350738 - Sequence 331762 from Patent EP1572962.
JD078646 - Sequence 59670 from Patent EP1572962.
JD290040 - Sequence 271064 from Patent EP1572962.
JD386610 - Sequence 367634 from Patent EP1572962.
LF206389 - JP 2014500723-A/13892: Polycomb-Associated Non-Coding RNAs.
JD237467 - Sequence 218491 from Patent EP1572962.
JD552921 - Sequence 533945 from Patent EP1572962.
LF353849 - JP 2014500723-A/161352: Polycomb-Associated Non-Coding RNAs.
JD347970 - Sequence 328994 from Patent EP1572962.
LF353848 - JP 2014500723-A/161351: Polycomb-Associated Non-Coding RNAs.
JD381881 - Sequence 362905 from Patent EP1572962.
LF353847 - JP 2014500723-A/161350: Polycomb-Associated Non-Coding RNAs.
JD237517 - Sequence 218541 from Patent EP1572962.
JD504091 - Sequence 485115 from Patent EP1572962.
LF353846 - JP 2014500723-A/161349: Polycomb-Associated Non-Coding RNAs.
JD082238 - Sequence 63262 from Patent EP1572962.
JD082553 - Sequence 63577 from Patent EP1572962.
LF353845 - JP 2014500723-A/161348: Polycomb-Associated Non-Coding RNAs.
MA441966 - JP 2018138019-A/13892: Polycomb-Associated Non-Coding RNAs.
MA589426 - JP 2018138019-A/161352: Polycomb-Associated Non-Coding RNAs.
MA589425 - JP 2018138019-A/161351: Polycomb-Associated Non-Coding RNAs.
MA589424 - JP 2018138019-A/161350: Polycomb-Associated Non-Coding RNAs.
MA589423 - JP 2018138019-A/161349: Polycomb-Associated Non-Coding RNAs.
MA589422 - JP 2018138019-A/161348: Polycomb-Associated Non-Coding RNAs.
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000315367.1, ENST00000315367.2, ENST00000315367.3, NM_024613, PKHF2_HUMAN, Q9H8W4, uc317pul.1, uc317pul.2, ZFYVE18
UCSC ID: ENST00000315367.4_5
RefSeq Accession: NM_024613.4
Protein: Q9H8W4
(aka PKHF2_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
