Human Gene NXT1 (ENST00000254998.3_4) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: NXT1_HUMAN
DESCRIPTION: RecName: Full=NTF2-related export protein 1; AltName: Full=Protein p15;
FUNCTION: Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5.
SUBUNIT: Heterodimer with NXF1. Interacts (via NTF2 domain) with NXF1. Stablizes the NTF2 domain of NXF1 by heterodimerization. The formation of NXF1/NXT1 heterodimers is required for the NXF1- mediated nuclear mRNA export. Preferentially binds Ran-GTP. Associates with NXF2, NXF3 and NXF5. Does not bind nucleoporins (NPC) directly, its association to NPC is mediated by NXF1.
INTERACTION: Q9UBU9:NXF1; NbExp=2; IntAct=EBI-301889, EBI-398874; Q9H4D5:NXF3; NbExp=3; IntAct=EBI-301889, EBI-750038; Q9BP41:Ranbp21 (xeno); NbExp=2; IntAct=EBI-301889, EBI-301896;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
SIMILARITY: Contains 1 NTF2 domain.
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Primer design for this transcript
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR002075 - NTF2
IPR018222 - Nuclear_transport_factor_2_euk
Pfam Domains:
PF02136 - Nuclear transport factor 2 (NTF2) domain
SCOP Domains:
54427 - NTF2-like
Protein Data Bank (PDB) 3-D Structure
MuPIT help
ModBase Predicted Comparative 3D Structure on Q9UKK6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC003410 - Homo sapiens NTF2-like export factor 1, mRNA (cDNA clone MGC:4978 IMAGE:3450767), complete cds.
AK026360 - Homo sapiens cDNA: FLJ22707 fis, clone HSI13259, highly similar to AF156957 Homo sapiens NTF2-related export protein NXT1 (NXT1) mRNA.
JD407095 - Sequence 388119 from Patent EP1572962.
BC000759 - Homo sapiens NTF2-like export factor 1, mRNA (cDNA clone MGC:2701 IMAGE:2820775), complete cds.
BC003029 - Homo sapiens NTF2-like export factor 1, mRNA (cDNA clone MGC:4329 IMAGE:2820775), complete cds.
AF156957 - Homo sapiens NTF2-related export protein NXT1 (NXT1) mRNA, complete cds.
BC002687 - Homo sapiens NTF2-like export factor 1, mRNA (cDNA clone MGC:3469 IMAGE:3608037), complete cds.
JD148755 - Sequence 129779 from Patent EP1572962.
JD380475 - Sequence 361499 from Patent EP1572962.
JD095944 - Sequence 76968 from Patent EP1572962.
JD062603 - Sequence 43627 from Patent EP1572962.
JD471396 - Sequence 452420 from Patent EP1572962.
JD178342 - Sequence 159366 from Patent EP1572962.
JD319035 - Sequence 300059 from Patent EP1572962.
CU678460 - Synthetic construct Homo sapiens gateway clone IMAGE:100017924 5' read NXT1 mRNA.
AB464644 - Synthetic construct DNA, clone: pF1KB8750, Homo sapiens NXT1 gene for NTF2-like export factor 1, without stop codon, in Flexi system.
KJ893687 - Synthetic construct Homo sapiens clone ccsbBroadEn_03081 NXT1 gene, encodes complete protein.
JD051842 - Sequence 32866 from Patent EP1572962.
JD554196 - Sequence 535220 from Patent EP1572962.
JD425648 - Sequence 406672 from Patent EP1572962.
JD220477 - Sequence 201501 from Patent EP1572962.
JD565301 - Sequence 546325 from Patent EP1572962.
JD133764 - Sequence 114788 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Reactome (by CSHL, EBI, and GO)
Protein Q9UKK6 (Reactome details) participates in the following event(s):
R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC
R-HSA-159101 NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)
R-HSA-75096 Docking of the TAP:EJC Complex with the NPC
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-8953854 Metabolism of RNA
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000254998.1, ENST00000254998.2, NM_013248, NXT1_HUMAN, Q9UKK6, uc317fqo.1, uc317fqo.2
UCSC ID: ENST00000254998.3_4
RefSeq Accession: NM_013248.3
Protein: Q9UKK6
(aka NXT1_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
