ID:NTM1A_HUMAN DESCRIPTION: RecName: Full=N-terminal Xaa-Pro-Lys N-methyltransferase 1; EC=2.1.1.244; AltName: Full=Alpha N-terminal protein methyltransferase 1A; AltName: Full=Methyltransferase-like protein 11A; AltName: Full=N-terminal RCC1 methyltransferase; AltName: Full=X-Pro-Lys N-terminal protein methyltransferase 1A; Short=NTM1A; FUNCTION: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1. CATALYTIC ACTIVITY: 3 S-adenosyl-L-methionine + N-terminal- (A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal- N,N,N-trimethyl-N-(A,S)PK-[protein]. CATALYTIC ACTIVITY: 2 S-adenosyl-L-methionine + N-terminal-PPK- [protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl- N-PPK-[protein]. INTERACTION: Q9Y2L1:DIS3; NbExp=1; IntAct=EBI-373016, EBI-373539; SUBCELLULAR LOCATION: Nucleus. Note=Predominantly nuclear. SIMILARITY: Belongs to the methyltransferase superfamily. NTM1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BV86
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
