Human Gene NPR3 (ENST00000265074.13_8) from GENCODE V47lift37
  Description: natriuretic peptide receptor 3, transcript variant 5 (from RefSeq NM_001364458.2)
Gencode Transcript: ENST00000265074.13_8
Gencode Gene: ENSG00000113389.16_12
Transcript (Including UTRs)
   Position: hg19 chr5:32,711,427-32,791,826 Size: 80,400 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg19 chr5:32,711,883-32,786,451 Size: 74,569 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:32,711,427-32,791,826)mRNA (may differ from genome)Protein (541 aa)
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-  Comments and Description Text from UniProtKB
  ID: ANPRC_HUMAN
DESCRIPTION: RecName: Full=Atrial natriuretic peptide receptor 3; AltName: Full=Atrial natriuretic peptide clearance receptor; AltName: Full=Atrial natriuretic peptide receptor type C; Short=ANP-C; Short=ANPR-C; Short=NPR-C; Flags: Precursor;
FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
SUBUNIT: Homodimer; disulfide-linked. Dimers can also be formed through the C-terminal cysteine of isoform 2.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
MISCELLANEOUS: Has low affinity for peptide hormones in the absence of bound chloride.
SIMILARITY: Belongs to the ANF receptor family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NPR3
Diseases sorted by gene-association score: short-rib thoracic dysplasia 5 with or without polydactyly (8), acromesomelic dysplasia (5), hypertension, essential (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.16 RPKM in Cells - Cultured fibroblasts
Total median expression: 21.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.80456-0.265 Picture PostScript Text
3' UTR -1425.905375-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001828 - ANF_lig-bd_rcpt
IPR001170 - Ntpep_rcpt

Pfam Domains:
PF01094 - Receptor family ligand binding region

SCOP Domains:
53822 - Periplasmic binding protein-like I

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1JDN - X-ray MuPIT 1JDP - X-ray MuPIT 1YK0 - X-ray MuPIT 1YK1 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P17342
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008528 G-protein coupled peptide receptor activity
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0031404 chloride ion binding
GO:0042277 peptide binding
GO:0042562 hormone binding
GO:0042803 protein homodimerization activity

Biological Process:
GO:0001501 skeletal system development
GO:0002158 osteoclast proliferation
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0030157 pancreatic juice secretion
GO:0033688 regulation of osteoblast proliferation
GO:0035810 positive regulation of urine volume
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity

Cellular Component:
GO:0005622 intracellular
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032991 macromolecular complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AK308301 - Homo sapiens cDNA, FLJ98249.
AK300094 - Homo sapiens cDNA FLJ60348 complete cds, highly similar to Atrial natriuretic peptide clearance receptor precursor.
AK290870 - Homo sapiens cDNA FLJ77482 complete cds, highly similar to Human atrial natriuretic peptide clearance receptor (ANP C-receptor) mRNA.
M59305 - Human atrial natriuretic peptide clearance receptor (ANP C-receptor) mRNA, complete cds.
BC131540 - Homo sapiens natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), mRNA (cDNA clone MGC:141892 IMAGE:40085188), complete cds.
X52282 - Human mRNA for atrial natriuretic peptide clearance receptor (ANP-C receptor).
KJ905243 - Synthetic construct Homo sapiens clone ccsbBroadEn_14719 NPR3-like gene, encodes complete protein.
AF025998 - Homo sapiens atrial natriuretic peptide clearance receptor (ANPRC) mRNA, complete cds.
JD300341 - Sequence 281365 from Patent EP1572962.
BC022250 - Homo sapiens chromosome 5 open reading frame 23, mRNA (cDNA clone MGC:22189 IMAGE:4702775), complete cds.
JD234471 - Sequence 215495 from Patent EP1572962.
JD225698 - Sequence 206722 from Patent EP1572962.
JD294558 - Sequence 275582 from Patent EP1572962.
AK024116 - Homo sapiens cDNA FLJ14054 fis, clone HEMBB1000240.
JD096110 - Sequence 77134 from Patent EP1572962.
KJ894696 - Synthetic construct Homo sapiens clone ccsbBroadEn_04090 NPR3 gene, encodes complete protein.
JD542256 - Sequence 523280 from Patent EP1572962.
JD438755 - Sequence 419779 from Patent EP1572962.
JD494653 - Sequence 475677 from Patent EP1572962.
JD157381 - Sequence 138405 from Patent EP1572962.
JD270877 - Sequence 251901 from Patent EP1572962.
JD164907 - Sequence 145931 from Patent EP1572962.
JD290749 - Sequence 271773 from Patent EP1572962.
JD408944 - Sequence 389968 from Patent EP1572962.
JD244729 - Sequence 225753 from Patent EP1572962.
JD502397 - Sequence 483421 from Patent EP1572962.
JD215867 - Sequence 196891 from Patent EP1572962.
JD182251 - Sequence 163275 from Patent EP1572962.
JD074030 - Sequence 55054 from Patent EP1572962.
JD036558 - Sequence 17582 from Patent EP1572962.
JD191535 - Sequence 172559 from Patent EP1572962.
JD233699 - Sequence 214723 from Patent EP1572962.
JD146821 - Sequence 127845 from Patent EP1572962.
JD051441 - Sequence 32465 from Patent EP1572962.
JD500627 - Sequence 481651 from Patent EP1572962.
JD224111 - Sequence 205135 from Patent EP1572962.
JD509129 - Sequence 490153 from Patent EP1572962.
JD298226 - Sequence 279250 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2RRD1, ANPRC, ANPRC_HUMAN, B4DT84, C5orf23, E7EPG9, ENST00000265074.1, ENST00000265074.10, ENST00000265074.11, ENST00000265074.12, ENST00000265074.2, ENST00000265074.3, ENST00000265074.4, ENST00000265074.5, ENST00000265074.6, ENST00000265074.7, ENST00000265074.8, ENST00000265074.9, NM_001364458, NPRC, P17342, uc317hyg.1, uc317hyg.2
UCSC ID: ENST00000265074.13_8
RefSeq Accession: NM_001204375.2
Protein: P17342 (aka ANPRC_HUMAN or ANPC_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.