Human Gene NOM1 (ENST00000275820.4_4) from GENCODE V47lift37

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Description: nucleolar protein with MIF4G domain 1, transcript variant 1 (from RefSeq NM_138400.2)
Gencode Transcript: ENST00000275820.4_4
Gencode Gene: ENSG00000146909.8_7
Transcript (Including UTRs)
Position: hg19 chr7:156,742,406-156,765,870 Size: 23,465 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr7:156,742,432-156,762,397 Size: 19,966 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:156,742,406-156,765,870)			mRNA (may differ from genome)		Protein (860 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NOM1_HUMAN DESCRIPTION: RecName: Full=Nucleolar MIF4G domain-containing protein 1; AltName: Full=SGD1 homolog; FUNCTION: Plays a role in targeting PPP1CA to the nucleolus. SUBUNIT: May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC. SUBCELLULAR LOCATION: Nucleus, nucleolus. TISSUE SPECIFICITY: Expressed in heart and skeletal muscle. SIMILARITY: Belongs to the CWC22 family. SIMILARITY: Contains 1 MI domain. SIMILARITY: Contains 1 MIF4G domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NOM1 Diseases sorted by gene-association score: ovarian mucinous adenocarcinoma (7)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone C075773 4-phenylbutyric acid D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen D016604 Aflatoxin B1 D000535 Aluminum D003375 Coumestrol D004958 Estradiol D005472 Fluorouracil D005557 Formaldehyde C006780 bisphenol A

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 5.67 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 162.56 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-4.80	26	-0.185	Picture	PostScript	Text
3' UTR	-1263.60	3473	-0.364	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016024 - ARM-type_fold
IPR003891 - Initiation_fac_eIF4g_MI
IPR016021 - MIF4-like_typ_1/2/3
IPR003890 - MIF4G-like_typ-3

Pfam Domains:
PF02847 - MA3 domain
PF02854 - MIF4G domain

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q5C9Z4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding Biological Process: GO:0008150 biological_process GO:0022008 neurogenesis GO:0042274 ribosomal small subunit biogenesis GO:0048820 hair follicle maturation Cellular Component: GO:0005634 nucleus GO:0005730 nucleolus

Descriptions from all associated GenBank mRNAs


	AY576779 - Homo sapiens nucleolar protein with MIF4G domain 1 (NOM1) mRNA, complete cds. BC167821 - Synthetic construct Homo sapiens clone IMAGE:100068211, MGC:195828 nucleolar protein with MIF4G domain 1 (NOM1) mRNA, encodes complete protein. AF107455 - Homo sapiens clone HFBck28 mRNA sequence. BC007902 - Homo sapiens nucleolar protein with MIF4G domain 1, mRNA (cDNA clone IMAGE:4138787), partial cds. JD399406 - Sequence 380430 from Patent EP1572962. JD167981 - Sequence 149005 from Patent EP1572962. JD076250 - Sequence 57274 from Patent EP1572962. JD040230 - Sequence 21254 from Patent EP1572962. JD109061 - Sequence 90085 from Patent EP1572962. JD336427 - Sequence 317451 from Patent EP1572962. JD461153 - Sequence 442177 from Patent EP1572962. JD340375 - Sequence 321399 from Patent EP1572962. JD082711 - Sequence 63735 from Patent EP1572962. JD312389 - Sequence 293413 from Patent EP1572962. AK131362 - Homo sapiens cDNA FLJ16401 fis, clone UTERU2004299. AK308719 - Homo sapiens cDNA, FLJ98760. JD342807 - Sequence 323831 from Patent EP1572962. JD410794 - Sequence 391818 from Patent EP1572962. JD262247 - Sequence 243271 from Patent EP1572962. JD221542 - Sequence 202566 from Patent EP1572962. JD440590 - Sequence 421614 from Patent EP1572962. JD127834 - Sequence 108858 from Patent EP1572962. JD143883 - Sequence 124907 from Patent EP1572962. JD222878 - Sequence 203902 from Patent EP1572962. JD497706 - Sequence 478730 from Patent EP1572962. JD542633 - Sequence 523657 from Patent EP1572962. JD542635 - Sequence 523659 from Patent EP1572962. JD542634 - Sequence 523658 from Patent EP1572962. JD197939 - Sequence 178963 from Patent EP1572962. JD413137 - Sequence 394161 from Patent EP1572962. JD513738 - Sequence 494762 from Patent EP1572962. JD362395 - Sequence 343419 from Patent EP1572962. JD179453 - Sequence 160477 from Patent EP1572962. JD118073 - Sequence 99097 from Patent EP1572962. JD449747 - Sequence 430771 from Patent EP1572962. JD052806 - Sequence 33830 from Patent EP1572962. JD237823 - Sequence 218847 from Patent EP1572962. JD313664 - Sequence 294688 from Patent EP1572962. JD201671 - Sequence 182695 from Patent EP1572962. JD432095 - Sequence 413119 from Patent EP1572962. JD560007 - Sequence 541031 from Patent EP1572962. JD470612 - Sequence 451636 from Patent EP1572962. JD439856 - Sequence 420880 from Patent EP1572962. JD055822 - Sequence 36846 from Patent EP1572962. JD334195 - Sequence 315219 from Patent EP1572962. JD092895 - Sequence 73919 from Patent EP1572962. JD295344 - Sequence 276368 from Patent EP1572962. JD240836 - Sequence 221860 from Patent EP1572962. JD505561 - Sequence 486585 from Patent EP1572962. JD022485 - Sequence 3509 from Patent EP1572962. JD552373 - Sequence 533397 from Patent EP1572962. JD242928 - Sequence 223952 from Patent EP1572962. JD028935 - Sequence 9959 from Patent EP1572962. JD031103 - Sequence 12127 from Patent EP1572962. BC011187 - Homo sapiens, clone IMAGE:4151011, mRNA. JD388586 - Sequence 369610 from Patent EP1572962. JD457271 - Sequence 438295 from Patent EP1572962. DQ572187 - Homo sapiens piRNA piR-40299, complete sequence.

Other Names for This Gene


	Alternate Gene Symbols: C7orf3, ENST00000275820.1, ENST00000275820.2, ENST00000275820.3, NM_138400, NOM1_HUMAN, Q5C9Z4, Q96I08, uc317jiv.1, uc317jiv.2 UCSC ID: ENST00000275820.4_4 RefSeq Accession: NM_138400.2 Protein: Q5C9Z4 (aka NOM1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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