ID:NMU_HUMAN DESCRIPTION: RecName: Full=Neuromedin-U; Contains: RecName: Full=Neuromedin-U-25; Short=NmU-25; Flags: Precursor; FUNCTION: Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed throughout the enteric nervous system with highest levels being found in the jejunum. SIMILARITY: Belongs to the NmU family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P48645
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005102 receptor binding GO:0005515 protein binding GO:0031839 type 1 neuromedin U receptor binding GO:0031840 type 2 neuromedin U receptor binding GO:0042922 neuromedin U receptor binding
Biological Process: GO:0001659 temperature homeostasis GO:0001696 gastric acid secretion GO:0006940 regulation of smooth muscle contraction GO:0007186 G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007218 neuropeptide signaling pathway GO:0009648 photoperiodism GO:0010460 positive regulation of heart rate GO:0019233 sensory perception of pain GO:0031652 positive regulation of heat generation GO:0042755 eating behavior GO:0044497 positive regulation of blood pressure in other organism GO:0045187 regulation of circadian sleep/wake cycle, sleep GO:0045987 positive regulation of smooth muscle contraction GO:0046887 positive regulation of hormone secretion GO:0050806 positive regulation of synaptic transmission GO:0060259 regulation of feeding behavior GO:0060455 negative regulation of gastric acid secretion GO:0097009 energy homeostasis GO:1902722 positive regulation of prolactin secretion GO:1903999 negative regulation of eating behavior GO:1904058 positive regulation of sensory perception of pain GO:2000252 negative regulation of feeding behavior GO:2000821 regulation of grooming behavior
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
