Human Gene NMT2 (ENST00000378165.9_7) from GENCODE V47lift37

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Description: N-myristoyltransferase 2, transcript variant 1 (from RefSeq NM_004808.3)
Gencode Transcript: ENST00000378165.9_7
Gencode Gene: ENSG00000152465.18_10
Transcript (Including UTRs)
Position: hg19 chr10:15,147,769-15,210,692 Size: 62,924 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr10:15,151,194-15,210,611 Size: 59,418 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:15,147,769-15,210,692)			mRNA (may differ from genome)		Protein (498 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	Reactome	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NMT2_HUMAN DESCRIPTION: RecName: Full=Glycylpeptide N-tetradecanoyltransferase 2; EC=2.3.1.97; AltName: Full=Myristoyl-CoA:protein N-myristoyltransferase 2; Short=NMT 2; AltName: Full=Peptide N-myristoyltransferase 2; AltName: Full=Type II N-myristoyltransferase; FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. CATALYTIC ACTIVITY: Tetradecanoyl-CoA + glycylpeptide = CoA + N- tetradecanoylglycylpeptide. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the NMT family. CAUTION: Sequence AAF36406.2 was incorrectly indicated as originating from bovine.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone D000082 Acetaminophen D002794 Choline D019327 Copper Sulfate D003375 Coumestrol D003474 Curcumin D016572 Cyclosporine D003993 Dibutyl Phthalate more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 14.59 RPKM in Adipose - Subcutaneous Total median expression: 262.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-42.60	81	-0.526	Picture	PostScript	Text
3' UTR	-1145.10	3425	-0.334	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR016181 - Acyl_CoA_acyltransferase
IPR000903 - MyristoylCoA_TrFase
IPR022677 - MyristoylCoA_TrFase_C
IPR022678 - MyristoylCoA_TrFase_CS
IPR022676 - MyristoylCoA_TrFase_N

Pfam Domains:
PF01233 - Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
PF02799 - Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

SCOP Domains:
55729 - Acyl-CoA N-acyltransferases (Nat)

ModBase Predicted Comparative 3D Structure on O60551


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004379 glycylpeptide N-tetradecanoyltransferase activity GO:0016740 transferase activity GO:0016746 transferase activity, transferring acyl groups Biological Process: GO:0006499 N-terminal protein myristoylation GO:0018008 N-terminal peptidyl-glycine N-myristoylation GO:0022400 regulation of rhodopsin mediated signaling pathway GO:0075733 intracellular transport of virus Cellular Component: GO:0005737 cytoplasm GO:0005794 Golgi apparatus GO:0005829 cytosol GO:0005886 plasma membrane GO:0016020 membrane GO:0019898 extrinsic component of membrane GO:0043657 host cell

Descriptions from all associated GenBank mRNAs


	AF043325 - Homo sapiens N-myristoyltransferase 2 mRNA, complete cds. BC006376 - Homo sapiens N-myristoyltransferase 2, mRNA (cDNA clone MGC:12700 IMAGE:4299115), complete cds. AK094904 - Homo sapiens cDNA FLJ37585 fis, clone BRCOC2005542, highly similar to Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97). AK295277 - Homo sapiens cDNA FLJ52915 complete cds, highly similar to Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97). BT007024 - Homo sapiens N-myristoyltransferase 2 mRNA, complete cds. DQ890667 - Synthetic construct clone IMAGE:100003297; FLH164931.01X; RZPDo839D09158D N-myristoyltransferase 2 (NMT2) gene, encodes complete protein. AK315085 - Homo sapiens cDNA, FLJ96041, highly similar to Homo sapiens N-myristoyltransferase 2 (NMT2), mRNA. KJ898016 - Synthetic construct Homo sapiens clone ccsbBroadEn_07410 NMT2 gene, encodes complete protein. DQ893848 - Synthetic construct Homo sapiens clone IMAGE:100008308; FLH164927.01L; RZPDo839D09157D N-myristoyltransferase 2 (NMT2) gene, encodes complete protein. CU675371 - Synthetic construct Homo sapiens gateway clone IMAGE:100018351 5' read NMT2 mRNA. BC005232 - Homo sapiens N-myristoyltransferase 2, mRNA (cDNA clone IMAGE:3838507), partial cds. AK025065 - Homo sapiens cDNA: FLJ21412 fis, clone COL03987. AK123732 - Homo sapiens cDNA FLJ41738 fis, clone HSYRA2002103. JD443526 - Sequence 424550 from Patent EP1572962. JD512773 - Sequence 493797 from Patent EP1572962. JD412800 - Sequence 393824 from Patent EP1572962. JD197814 - Sequence 178838 from Patent EP1572962. JD212423 - Sequence 193447 from Patent EP1572962. JD222865 - Sequence 203889 from Patent EP1572962. JD512772 - Sequence 493796 from Patent EP1572962. JD412799 - Sequence 393823 from Patent EP1572962. JD373784 - Sequence 354808 from Patent EP1572962. JD277537 - Sequence 258561 from Patent EP1572962. JD421976 - Sequence 403000 from Patent EP1572962. JD446462 - Sequence 427486 from Patent EP1572962. AF086423 - Homo sapiens full length insert cDNA clone ZD78F07. JD219988 - Sequence 201012 from Patent EP1572962. JD517936 - Sequence 498960 from Patent EP1572962. JD366682 - Sequence 347706 from Patent EP1572962. JD138243 - Sequence 119267 from Patent EP1572962. JD344691 - Sequence 325715 from Patent EP1572962. JD447097 - Sequence 428121 from Patent EP1572962. JD322437 - Sequence 303461 from Patent EP1572962. JD306910 - Sequence 287934 from Patent EP1572962. JD170067 - Sequence 151091 from Patent EP1572962. JD529606 - Sequence 510630 from Patent EP1572962. JD557517 - Sequence 538541 from Patent EP1572962. JD430414 - Sequence 411438 from Patent EP1572962. JD201336 - Sequence 182360 from Patent EP1572962. JD134045 - Sequence 115069 from Patent EP1572962. JD170066 - Sequence 151090 from Patent EP1572962. JD211766 - Sequence 192790 from Patent EP1572962. JD217806 - Sequence 198830 from Patent EP1572962. JD522460 - Sequence 503484 from Patent EP1572962. JD351481 - Sequence 332505 from Patent EP1572962. JD427159 - Sequence 408183 from Patent EP1572962. JD244346 - Sequence 225370 from Patent EP1572962. AK302101 - Homo sapiens cDNA FLJ54198 complete cds, highly similar to Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97).

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein O60551 (Reactome details) participates in the following event(s): R-HSA-184392 N-myristoylation of GAG polyprotein by NMT2 R-HSA-2534087 NMT1/2 transfer MYS to GNAT1 R-HSA-174490 Membrane binding and targetting of GAG proteins R-HSA-174495 Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade R-HSA-175474 Assembly Of The HIV Virion R-HSA-2514856 The phototransduction cascade R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-2187338 Visual phototransduction R-HSA-162587 HIV Life Cycle R-HSA-418594 G alpha (i) signalling events R-HSA-162906 HIV Infection R-HSA-388396 GPCR downstream signalling R-HSA-5663205 Infectious disease R-HSA-372790 Signaling by GPCR R-HSA-1643685 Disease R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: B0YJ49, ENST00000378165.1, ENST00000378165.2, ENST00000378165.3, ENST00000378165.4, ENST00000378165.5, ENST00000378165.6, ENST00000378165.7, ENST00000378165.8, NMT2 , NMT2_HUMAN, NM_004808, O60551, Q53Y38, Q5VUC8, Q9BRB4, uc318ocm.1, uc318ocm.2 UCSC ID: ENST00000378165.9_7 RefSeq Accession: NM_004808.3 Protein: O60551 (aka NMT2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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