Human Gene NMB (ENST00000360476.8_13) from GENCODE V47lift37
  Description: neuromedin B, transcript variant 1 (from RefSeq NM_021077.4)
Gencode Transcript: ENST00000360476.8_13
Gencode Gene: ENSG00000197696.10_15
Transcript (Including UTRs)
   Position: hg19 chr15:85,198,363-85,201,430 Size: 3,068 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr15:85,198,605-85,201,383 Size: 2,779 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:85,198,363-85,201,430)mRNA (may differ from genome)Protein (121 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NMB_HUMAN
DESCRIPTION: RecName: Full=Neuromedin-B; Contains: RecName: Full=Neuromedin-B-32; Contains: RecName: Full=Neuromedin-B; Flags: Precursor;
FUNCTION: Stimulates smooth muscle contraction in a manner similar to that of bombesin.
SUBCELLULAR LOCATION: Secreted.
SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NMB
Diseases sorted by gene-association score: gastrinoma (12), neuronal ceroid lipofuscinosis (6), lung cancer (4), obesity (3), small cell cancer of the lung, somatic (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.76 RPKM in Adipose - Visceral (Omentum)
Total median expression: 276.47 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.3047-0.432 Picture PostScript Text
3' UTR -66.70242-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000874 - Bombesin

Pfam Domains:
PF02044 - Bombesin-like peptide

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1C98 - NMR 1C9A - NMR


ModBase Predicted Comparative 3D Structure on P08949
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005179 hormone activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007267 cell-cell signaling
GO:0010469 regulation of receptor activity

Cellular Component:
GO:0005576 extracellular region


-  Descriptions from all associated GenBank mRNAs
  BC007407 - Homo sapiens neuromedin B, mRNA (cDNA clone MGC:2277 IMAGE:3030430), complete cds.
BC007431 - Homo sapiens neuromedin B, mRNA (cDNA clone MGC:3936 IMAGE:3030430), complete cds.
BC008603 - Homo sapiens neuromedin B, mRNA (cDNA clone MGC:17211 IMAGE:4185578), complete cds.
M21551 - Human neuromedin B mRNA, complete cds.
JD090845 - Sequence 71869 from Patent EP1572962.
AL110112 - Homo sapiens EST from clone 323828, 5' end.
JD421211 - Sequence 402235 from Patent EP1572962.
KJ897249 - Synthetic construct Homo sapiens clone ccsbBroadEn_06643 NMB gene, encodes complete protein.
KR709975 - Synthetic construct Homo sapiens clone CCSBHm_00008596 NMB (NMB) mRNA, encodes complete protein.
JD237844 - Sequence 218868 from Patent EP1572962.
KJ905837 - Synthetic construct Homo sapiens clone ccsbBroadEn_15507 NMB gene, encodes complete protein.
JD056606 - Sequence 37630 from Patent EP1572962.
JD127459 - Sequence 108483 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P08949 (Reactome details) participates in the following event(s):

R-HSA-375384 Bombesin-like receptors bind bombesin homologues
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000360476.1, ENST00000360476.2, ENST00000360476.3, ENST00000360476.4, ENST00000360476.5, ENST00000360476.6, ENST00000360476.7, NMB_HUMAN, NM_021077, P08949, Q96A06, Q96HH5, uc318bop.1, uc318bop.2
UCSC ID: ENST00000360476.8_13
RefSeq Accession: NM_021077.4
Protein: P08949 (aka NMB_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.