ID:NEST_HUMAN DESCRIPTION: RecName: Full=Nestin; FUNCTION: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). SUBUNIT: Forms homodimers and homotetramers in vitro. In mixtures with other intermediate filament proteins such as vimentin and alpha-internexin, tis protein preferentially forms heterodimers which can assemble to form intermediate filaments if nestin does not exceed 25%. Interacts with FHOD3 (By similarity). TISSUE SPECIFICITY: CNS stem cells. DEVELOPMENTAL STAGE: Upon terminal neural differentiation, nestin is down-regulated and replaced by neurofilaments. PTM: Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity). SIMILARITY: Belongs to the intermediate filament family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00038 - Intermediate filament protein
SCOP Domains: 64593 - Intermediate filament protein, coiled coil region
ModBase Predicted Comparative 3D Structure on P48681
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000086 G2/M transition of mitotic cell cycle GO:0007275 multicellular organism development GO:0007399 nervous system development GO:0007417 central nervous system development GO:0007420 brain development GO:0030844 positive regulation of intermediate filament depolymerization GO:0031076 embryonic camera-type eye development GO:0032091 negative regulation of protein binding GO:0043086 negative regulation of catalytic activity GO:0072089 stem cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
