ID:NEK3_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase Nek3; EC=2.7.11.1; AltName: Full=HSPK 36; AltName: Full=Never in mitosis A-related kinase 3; Short=NimA-related protein kinase 3; FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin- mediated phosphorylation of PXN and VAV2. Implicated in prolactin- mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Prolactin stimulates its activity. SUBUNIT: Interacts with PXN, PRLR, VAV1 and VAV2 and this interaction is prolactin-dependent. INTERACTION: P52735:VAV2; NbExp=3; IntAct=EBI-476041, EBI-297549; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, axon (By similarity). TISSUE SPECIFICITY: Up-regulated in malignant versus normal breast tissue. Isoform 2 shows a high level of expression in testis, ovary and brain. PTM: Phosphorylation at Thr-479 regulates its catalytic activity (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=CAI12895.1; Type=Erroneous gene model prediction; Sequence=EAX08907.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00069 - Protein kinase domain PF03109 - ABC1 atypical kinase-like domain PF07714 - Protein tyrosine and serine/threonine kinase PF14531 - Kinase-like
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on P51956
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
