ID:NDUV3_HUMAN DESCRIPTION: RecName: Full=NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; AltName: Full=Complex I-9kD; Short=CI-9kD; AltName: Full=NADH-ubiquinone oxidoreductase 9 kDa subunit; AltName: Full=Renal carcinoma antigen NY-REN-4; Flags: Precursor; FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. SUBUNIT: Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. SIMILARITY: Belongs to the complex I NDUFV3 subunit family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P56181
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0032981 mitochondrial respiratory chain complex I assembly GO:0042775 mitochondrial ATP synthesis coupled electron transport GO:0055114 oxidation-reduction process
AK056041 - Homo sapiens cDNA FLJ31479 fis, clone NT2NE2001634, moderately similar to NADH-UBIQUINONE OXIDOREDUCTASE 9 KD SUBUNIT PRECURSOR (EC 1.6.5.3). LF385182 - JP 2014500723-A/192685: Polycomb-Associated Non-Coding RNAs. BC054016 - Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa, mRNA (cDNA clone IMAGE:6739558), complete cds. BC021217 - Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa, mRNA (cDNA clone MGC:12790 IMAGE:4302265), complete cds. AK308228 - Homo sapiens cDNA, FLJ98176. AK289586 - Homo sapiens cDNA FLJ76512 complete cds, highly similar to Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (NDUFV3), transcript variant 2, mRNA. BC033766 - Homo sapiens NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa, mRNA (cDNA clone IMAGE:4177041), complete cds. CU676876 - Synthetic construct Homo sapiens gateway clone IMAGE:100017339 5' read NDUFV3 mRNA. CU689730 - Synthetic construct Homo sapiens gateway clone IMAGE:100017905 5' read NDUFV3 mRNA. KJ891685 - Synthetic construct Homo sapiens clone ccsbBroadEn_01079 NDUFV3 gene, encodes complete protein. KJ897232 - Synthetic construct Homo sapiens clone ccsbBroadEn_06626 NDUFV3 gene, encodes complete protein. CR542190 - Homo sapiens full open reading frame cDNA clone RZPDo834G0524D for gene NDUFV3, NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa; complete cds, without stopcodon. CR542174 - Homo sapiens full open reading frame cDNA clone RZPDo834B0924D for gene NDUFV3, NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa; complete cds, incl. stopcodon. LF341033 - JP 2014500723-A/148536: Polycomb-Associated Non-Coding RNAs. AY173949 - Homo sapiens mitochondrial NADH oxidoreductase-like protein mRNA, complete cds; nuclear gene for mitochondrial product. DQ892718 - Synthetic construct clone IMAGE:100005348; FLH189081.01X; RZPDo839B0574D NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (NDUFV3) gene, encodes complete protein. DQ895967 - Synthetic construct Homo sapiens clone IMAGE:100010427; FLH189077.01L; RZPDo839B0564D NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa (NDUFV3) gene, encodes complete protein. LF341034 - JP 2014500723-A/148537: Polycomb-Associated Non-Coding RNAs. LF341035 - JP 2014500723-A/148538: Polycomb-Associated Non-Coding RNAs. LF341036 - JP 2014500723-A/148539: Polycomb-Associated Non-Coding RNAs. LF341037 - JP 2014500723-A/148540: Polycomb-Associated Non-Coding RNAs. LF341038 - JP 2014500723-A/148541: Polycomb-Associated Non-Coding RNAs. JD143641 - Sequence 124665 from Patent EP1572962. JD287529 - Sequence 268553 from Patent EP1572962. JD536583 - Sequence 517607 from Patent EP1572962. JD514047 - Sequence 495071 from Patent EP1572962. JD514048 - Sequence 495072 from Patent EP1572962. JD121114 - Sequence 102138 from Patent EP1572962. JD381331 - Sequence 362355 from Patent EP1572962. JD381332 - Sequence 362356 from Patent EP1572962. JD537304 - Sequence 518328 from Patent EP1572962. JD100945 - Sequence 81969 from Patent EP1572962. JD142589 - Sequence 123613 from Patent EP1572962. JD196144 - Sequence 177168 from Patent EP1572962. JD140161 - Sequence 121185 from Patent EP1572962. JD381003 - Sequence 362027 from Patent EP1572962. JD089587 - Sequence 70611 from Patent EP1572962. JD135531 - Sequence 116555 from Patent EP1572962. JD222924 - Sequence 203948 from Patent EP1572962. JD543279 - Sequence 524303 from Patent EP1572962. JD478592 - Sequence 459616 from Patent EP1572962. JD478593 - Sequence 459617 from Patent EP1572962. JD463841 - Sequence 444865 from Patent EP1572962. JD463796 - Sequence 444820 from Patent EP1572962. JD148284 - Sequence 129308 from Patent EP1572962. JD488590 - Sequence 469614 from Patent EP1572962. JD199439 - Sequence 180463 from Patent EP1572962. JD421430 - Sequence 402454 from Patent EP1572962. JD179041 - Sequence 160065 from Patent EP1572962. JD179042 - Sequence 160066 from Patent EP1572962. JD187786 - Sequence 168810 from Patent EP1572962. DQ596756 - Homo sapiens piRNA piR-34822, complete sequence. JD558418 - Sequence 539442 from Patent EP1572962. MA620759 - JP 2018138019-A/192685: Polycomb-Associated Non-Coding RNAs. MA576610 - JP 2018138019-A/148536: Polycomb-Associated Non-Coding RNAs. MA576611 - JP 2018138019-A/148537: Polycomb-Associated Non-Coding RNAs. MA576612 - JP 2018138019-A/148538: Polycomb-Associated Non-Coding RNAs. MA576613 - JP 2018138019-A/148539: Polycomb-Associated Non-Coding RNAs. MA576614 - JP 2018138019-A/148540: Polycomb-Associated Non-Coding RNAs. MA576615 - JP 2018138019-A/148541: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
Reactome (by CSHL, EBI, and GO)
Protein P56181 (Reactome details) participates in the following event(s):
R-HSA-6800870 NDUF subunits bind to form the FP subcomplex R-HSA-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex R-HSA-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 R-HSA-6799198 Complex I biogenesis R-HSA-611105 Respiratory electron transport R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
