Human Gene NDUFA3 (ENST00000485876.6_4) from GENCODE V47lift37

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Description: NADH:ubiquinone oxidoreductase subunit A3 (from RefSeq NM_004542.4)
Gencode Transcript: ENST00000485876.6_4
Gencode Gene: ENSG00000170906.16_10
Transcript (Including UTRs)
Position: hg19 chr19:54,606,163-54,610,875 Size: 4,713 Total Exon Count: 4 Strand: +
Coding Region
Position: hg19 chr19:54,606,187-54,610,209 Size: 4,023 Coding Exon Count: 4

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:54,606,163-54,610,875)			mRNA (may differ from genome)		Protein (84 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D012402 Rotenone C006253 pirinixic acid D000082 Acetaminophen D002994 Clofibrate D003407 Creosote D016572 Cyclosporine D003993 Dibutyl Phthalate D004051 Diethylhexyl Phthalate D004958 Estradiol D005485 Flutamide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 24.59 RPKM in Heart - Left Ventricle Total median expression: 652.14 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-7.60	24	-0.317	Picture	PostScript	Text
3' UTR	-225.70	666	-0.339	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR026626 - NDUFA3

Pfam Domains:
PF14987 - NADH dehydrogenase 1 alpha subcomplex subunit 3

ModBase Predicted Comparative 3D Structure on Q6FGG4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0005743 mitochondrial inner membrane GO:0005747 mitochondrial respiratory chain complex I GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AF070653 - Homo sapiens NADH-ubiquinone oxidoreductase subunit B9 homolog mRNA, complete cds. BC061644 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa, mRNA (cDNA clone MGC:70789 IMAGE:5748578), complete cds. BC011021 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa, mRNA (cDNA clone IMAGE:4280437), partial cds. BC022369 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa, mRNA (cDNA clone MGC:23902 IMAGE:4737656), complete cds. AK289489 - Homo sapiens cDNA FLJ76508 complete cds, highly similar to Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa (NDUFA3), mRNA. AF044955 - Homo sapiens NADH:ubiquinone oxidoreductase B9 subunit mRNA, nuclear gene encoding mitochondrial protein, complete cds. CR542143 - Homo sapiens full open reading frame cDNA clone RZPDo834H0323D for gene NDUFA3, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa; complete cds, incl. stopcodon. DQ891360 - Synthetic construct clone IMAGE:100003990; FLH176198.01X; RZPDo839A08122D NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa (NDUFA3) gene, encodes complete protein. DQ894540 - Synthetic construct Homo sapiens clone IMAGE:100009000; FLH176194.01L; RZPDo839A08121D NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa (NDUFA3) gene, encodes complete protein. KJ891671 - Synthetic construct Homo sapiens clone ccsbBroadEn_01065 NDUFA3 gene, encodes complete protein. JD434592 - Sequence 415616 from Patent EP1572962. JD473807 - Sequence 454831 from Patent EP1572962. CU678655 - Synthetic construct Homo sapiens gateway clone IMAGE:100018060 3' read TFPT mRNA. JD024715 - Sequence 5739 from Patent EP1572962. JD256519 - Sequence 237543 from Patent EP1572962. JD476694 - Sequence 457718 from Patent EP1572962. JD560672 - Sequence 541696 from Patent EP1572962. JD476695 - Sequence 457719 from Patent EP1572962. JD557991 - Sequence 539015 from Patent EP1572962. JD172886 - Sequence 153910 from Patent EP1572962. JD397025 - Sequence 378049 from Patent EP1572962. JD414735 - Sequence 395759 from Patent EP1572962. JD120511 - Sequence 101535 from Patent EP1572962. JD094078 - Sequence 75102 from Patent EP1572962. JD311583 - Sequence 292607 from Patent EP1572962. JD311584 - Sequence 292608 from Patent EP1572962. JD081341 - Sequence 62365 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)

Other Names for This Gene


	Alternate Gene Symbols: ENST00000485876.1, ENST00000485876.2, ENST00000485876.3, ENST00000485876.4, ENST00000485876.5, hCG_20947 , NDUFA3 , NM_004542, Q6FGG4, Q6FGG4_HUMAN, uc322fux.1, uc322fux.2 UCSC ID: ENST00000485876.6_4 RefSeq Accession: NM_004542.4 Protein: Q6FGG4

Gene Model Information


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Methods, Credits, and Use Restrictions


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