Human Gene MTCH2 (ENST00000302503.8_7) from GENCODE V47lift37

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Description: mitochondrial carrier 2, transcript variant 1 (from RefSeq NM_014342.4)
Gencode Transcript: ENST00000302503.8_7
Gencode Gene: ENSG00000109919.10_11
Transcript (Including UTRs)
Position: hg19 chr11:47,638,869-47,664,111 Size: 25,243 Total Exon Count: 13 Strand: -
Coding Region
Position: hg19 chr11:47,640,385-47,664,017 Size: 23,633 Coding Exon Count: 13

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:47,638,869-47,664,111)			mRNA (may differ from genome)		Protein (303 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: MTCH2_HUMAN DESCRIPTION: RecName: Full=Mitochondrial carrier homolog 2; AltName: Full=Met-induced mitochondrial protein; FUNCTION: The substrate transported is not yet known. Induces mitochondrial depolarization. SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the mitochondrial carrier family. SIMILARITY: Contains 2 Solcar repeats.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MTCH2 Diseases sorted by gene-association score: obesity (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D019327 Copper Sulfate D013749 Tetrachlorodibenzodioxin C049325 1,2-dithiol-3-thione C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid D000082 Acetaminophen C099555 CD 437 D002922 Ciguatoxins D003513 Cycloheximide more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 56.75 RPKM in Testis Total median expression: 905.19 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-40.40	94	-0.430	Picture	PostScript	Text
3' UTR	-347.60	1516	-0.229	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR018108 - Mitochondrial_sb/sol_carrier
IPR023395 - Mt_carrier_dom

Pfam Domains:
PF00153 - Mitochondrial carrier protein

SCOP Domains:
103506 - Mitochondrial carrier

ModBase Predicted Comparative 3D Structure on Q9Y6C9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0043065 positive regulation of apoptotic process GO:0070585 protein localization to mitochondrion Cellular Component: GO:0005634 nucleus GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	LF383702 - JP 2014500723-A/191205: Polycomb-Associated Non-Coding RNAs. AY380792 - Homo sapiens Met-induced mitochondrial protein long form (MIMP) mRNA, complete cds; nuclear gene for mitochondrial product. AK223097 - Homo sapiens mRNA for mitochondrial carrier homolog 2 variant, clone: KAT04018. AK295218 - Homo sapiens cDNA FLJ51849 complete cds, highly similar to Mitochondrial carrier homolog 2. BC000875 - Homo sapiens mitochondrial carrier homolog 2 (C. elegans), mRNA (cDNA clone MGC:4903 IMAGE:3461469), complete cds. AF085361 - Homo sapiens HSPC032 mRNA, complete cds. AF176008 - Homo sapiens mitochondrial carrier homolog 2 mRNA, complete cds; nuclear gene for mitochondrial product. LF347868 - JP 2014500723-A/155371: Polycomb-Associated Non-Coding RNAs. LF347867 - JP 2014500723-A/155370: Polycomb-Associated Non-Coding RNAs. JD375573 - Sequence 356597 from Patent EP1572962. AK313032 - Homo sapiens cDNA, FLJ93503, Homo sapiens mitochondrial carrier homolog 2 (C. elegans) (MTCH2),nuclear gene encoding mitochondrial protein, mRNA. CU674434 - Synthetic construct Homo sapiens gateway clone IMAGE:100018780 5' read MTCH2 mRNA. KJ893448 - Synthetic construct Homo sapiens clone ccsbBroadEn_02842 MTCH2 gene, encodes complete protein. DQ891810 - Synthetic construct clone IMAGE:100004440; FLH180151.01X; RZPDo839G06132D mitochondrial carrier homolog 2 (C. elegans) (MTCH2) gene, encodes complete protein; nuclear gene for mitochondrial product. DQ894993 - Synthetic construct Homo sapiens clone IMAGE:100009453; FLH180147.01L; RZPDo839G06131D mitochondrial carrier homolog 2 (C. elegans) (MTCH2) gene, encodes complete protein; nuclear gene for mitochondrial product. LF347861 - JP 2014500723-A/155364: Polycomb-Associated Non-Coding RNAs. MA619279 - JP 2018138019-A/191205: Polycomb-Associated Non-Coding RNAs. MA583445 - JP 2018138019-A/155371: Polycomb-Associated Non-Coding RNAs. MA583444 - JP 2018138019-A/155370: Polycomb-Associated Non-Coding RNAs. MA583438 - JP 2018138019-A/155364: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B2R7L8, ENST00000302503.1, ENST00000302503.2, ENST00000302503.3, ENST00000302503.4, ENST00000302503.5, ENST00000302503.6, ENST00000302503.7, HSPC032, MIMP , MTCH2 , MTCH2_HUMAN, NM_014342, Q9Y6C9, uc317nbe.1, uc317nbe.2 UCSC ID: ENST00000302503.8_7 RefSeq Accession: NM_001317231.2 Protein: Q9Y6C9 (aka MTCH2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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