Human Gene STK26 (ENST00000394334.7_4) from GENCODE V47lift37
  Description: serine/threonine kinase 26, transcript variant 1 (from RefSeq NM_016542.4)
Gencode Transcript: ENST00000394334.7_4
Gencode Gene: ENSG00000134602.16_7
Transcript (Including UTRs)
   Position: hg19 chrX:131,157,330-131,209,971 Size: 52,642 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chrX:131,157,646-131,208,187 Size: 50,542 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:131,157,330-131,209,971)mRNA (may differ from genome)Protein (416 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MST4_HUMAN
DESCRIPTION: RecName: Full=Serine/threonine-protein kinase MST4; EC=2.7.11.1; AltName: Full=Mammalian STE20-like protein kinase 4; Short=MST-4; AltName: Full=Mst3 and SOK1-related kinase; AltName: Full=STE20-like kinase MST4; AltName: Full=Serine/threonine-protein kinase MASK;
FUNCTION: Mediator of cell growth. Modulates apoptosis.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium (By similarity).
ENZYME REGULATION: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C- terminal cleavage.
SUBUNIT: Homodimer. Interacts with PDCD10 and GOLGA2.
INTERACTION: Self; NbExp=4; IntAct=EBI-618239, EBI-618239; Q9P2B4:CTTNBP2NL; NbExp=3; IntAct=EBI-618239, EBI-1774273; Q5VSL9:FAM40A; NbExp=2; IntAct=EBI-618239, EBI-1773588;
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the Golgi apparatus.
SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
SIMILARITY: Contains 1 protein kinase domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.26 RPKM in Uterus
Total median expression: 209.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -87.50216-0.405 Picture PostScript Text
3' UTR -365.801784-0.205 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom

Pfam Domains:
PF00069 - Protein kinase domain
PF07714 - Protein tyrosine and serine/threonine kinase

SCOP Domains:
56112 - Protein kinase-like (PK-like)

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3GGF - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9P289
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008349 MAP kinase kinase kinase kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding

Biological Process:
GO:0000165 MAPK cascade
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007346 regulation of mitotic cell cycle
GO:0009267 cellular response to starvation
GO:0016310 phosphorylation
GO:0030033 microvillus assembly
GO:0030336 negative regulation of cell migration
GO:0031098 stress-activated protein kinase signaling cascade
GO:0042542 response to hydrogen peroxide
GO:0042981 regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0048812 neuron projection morphogenesis
GO:1903205 regulation of hydrogen peroxide-induced cell death

Cellular Component:
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005829 cytosol
GO:0012506 vesicle membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular exosome
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  AB040057 - Homo sapiens mRNA for serine/threonine protein kinase MASK, complete cds.
AK316137 - Homo sapiens cDNA, FLJ79036 complete cds, highly similar to Serine/threonine-protein kinase MST4 (EC 2.7.11.1).
AK303583 - Homo sapiens cDNA FLJ54528 complete cds, highly similar to Serine/threonine-protein kinase MST4 (EC 2.7.11.1).
AK075150 - Homo sapiens cDNA FLJ90669 fis, clone PLACE1005519, moderately similar to Homo sapiens STE20-like kinase 3 (mst-3) mRNA.
AK314356 - Homo sapiens cDNA, FLJ95124, Homo sapiens Mst3 and SOK1-related kinase (MST4), mRNA.
BC070056 - Homo sapiens cDNA clone IMAGE:30344239, containing frame-shift errors.
AK075107 - Homo sapiens cDNA FLJ90626 fis, clone PLACE1003135, weakly similar to SPORULATION-SPECIFIC PROTEIN 1 (EC 2.7.1.-).
BC098315 - Homo sapiens serine/threonine protein kinase MST4, mRNA (cDNA clone MGC:120602 IMAGE:40026349), complete cds.
BC099737 - Homo sapiens cDNA clone IMAGE:40026351, containing frame-shift errors.
BC099843 - Homo sapiens serine/threonine protein kinase MST4, mRNA (cDNA clone MGC:120601 IMAGE:40026348), complete cds.
BC103503 - Homo sapiens serine/threonine protein kinase MST4, mRNA (cDNA clone MGC:120603 IMAGE:40026350), complete cds.
BC017213 - Homo sapiens serine/threonine protein kinase MST4, mRNA (cDNA clone IMAGE:3958088), containing frame-shift errors.
AF231012 - Homo sapiens STE20-like kinase MST4 (MST4) mRNA, complete cds.
AF344882 - Homo sapiens serine/threonine protein kinase MST4 (MST4) mRNA, complete cds, alternatively spliced.
AF344883 - Homo sapiens serine/threonine protein kinase MST4a (MST4) mRNA, complete cds, alternatively spliced.
AB527620 - Synthetic construct DNA, clone: pF1KE0934, Homo sapiens RP6-213H19.1 gene for serine/threonine protein kinase MST4, without stop codon, in Flexi system.
EU832781 - Synthetic construct Homo sapiens clone HAIB:100067810; DKFZo008B1233 serine/threonine protein kinase MST4 protein (RP6-213H19.1) gene, encodes complete protein.
GQ129321 - Synthetic construct Homo sapiens clone HAIB:100068470; DKFZo004B1234 serine/threonine protein kinase MST4 protein (RP6-213H19.1) gene, partial cds.
KJ902622 - Synthetic construct Homo sapiens clone ccsbBroadEn_12016 MST4 gene, encodes complete protein.
KJ905480 - Synthetic construct Homo sapiens clone ccsbBroadEn_15074 MST4 gene, encodes complete protein.
BT020099 - Homo sapiens Mst3 and SOK1-related kinase mRNA, complete cds.
AK000556 - Homo sapiens cDNA FLJ20549 fis, clone KAT11561.
AK074837 - Homo sapiens cDNA FLJ90356 fis, clone NT2RP2003545, weakly similar to Homo sapiens STE20-like kinase 3 (mst-3) mRNA.
AK027589 - Homo sapiens cDNA FLJ14683 fis, clone NT2RP2004768, weakly similar to SERINE/THREONINE-PROTEIN KINASE NRK1 (EC 2.7.1.-).
JD152149 - Sequence 133173 from Patent EP1572962.
JD058871 - Sequence 39895 from Patent EP1572962.
BC013856 - Homo sapiens Mst3 and SOK1-related kinase, mRNA (cDNA clone IMAGE:4522313).
JD357377 - Sequence 338401 from Patent EP1572962.
JD467663 - Sequence 448687 from Patent EP1572962.
JD532643 - Sequence 513667 from Patent EP1572962.
JD359476 - Sequence 340500 from Patent EP1572962.
JD083918 - Sequence 64942 from Patent EP1572962.
JD087243 - Sequence 68267 from Patent EP1572962.
JD501187 - Sequence 482211 from Patent EP1572962.
JD302890 - Sequence 283914 from Patent EP1572962.
JD313189 - Sequence 294213 from Patent EP1572962.
JD197710 - Sequence 178734 from Patent EP1572962.
JD433046 - Sequence 414070 from Patent EP1572962.
JD447765 - Sequence 428789 from Patent EP1572962.
JD080892 - Sequence 61916 from Patent EP1572962.
JD503590 - Sequence 484614 from Patent EP1572962.
JD350518 - Sequence 331542 from Patent EP1572962.
JD553340 - Sequence 534364 from Patent EP1572962.
JD451238 - Sequence 432262 from Patent EP1572962.
JD182041 - Sequence 163065 from Patent EP1572962.
JD353963 - Sequence 334987 from Patent EP1572962.
JD039245 - Sequence 20269 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9P289 (Reactome details) participates in the following event(s):

R-HSA-350651 Caspase-mediated cleavage of MASK
R-HSA-111465 Apoptotic cleavage of cellular proteins
R-HSA-75153 Apoptotic execution phase
R-HSA-109581 Apoptosis
R-HSA-5357801 Programmed Cell Death

-  Other Names for This Gene
  Alternate Gene Symbols: B2RAU2, ENST00000394334.1, ENST00000394334.2, ENST00000394334.3, ENST00000394334.4, ENST00000394334.5, ENST00000394334.6, MASK , MST4 , NM_016542, Q3ZB77, Q8NC04, Q9BXC3, Q9BXC4, Q9P289, STK26 , STK26_HUMAN, uc318wox.1, uc318wox.2
UCSC ID: ENST00000394334.7_4
RefSeq Accession: NM_016542.4
Protein: Q9P289 (aka MST4_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.