ID:MPDZ_HUMAN DESCRIPTION: RecName: Full=Multiple PDZ domain protein; AltName: Full=Multi-PDZ domain protein 1; FUNCTION: Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. SUBUNIT: Interacts with CLDN5, DLG4, GRIN1, F11R/JAM, CLDN1, NG2, CRB1, MPP4 and MPP5 (By similarity). Interacts with HTR2A, HTR2B, HTR2C, PLEKHA1/TAPP1, PLEKHA2/TAPP2, CXADR, SYNGAP1, CAMK2A and CAMK2B. Interacts with the adenovirus type 9 E4-ORF1 protein. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell junction, tight junction. Cell junction, synapse. Cell junction, synapse, synaptosome. Note=Associated with membranes. Colocalizes with HTR2C on the apical membrane of epithelial choroid plexus cells. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker DLG4. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells (By similarity). In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. TISSUE SPECIFICITY: Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. DOMAIN: The PDZ domain 1 binds NG2. The PDZ domains 7 and 10 bind the Ad9 E4-ORF1 oncoprotein. The PDZ domain 9 binds F11R. The PDZ domain 10 binds the C-terminus of CLDN1 and KIT and the C-terminal PDZ-binding motif of HTR2C. The PDZ domain 13 binds CXADR (By similarity). The PDZ domain 2 binds CAMK2A and CAMK2B. The PDZ domains 10 and 13 bind PLEKHA1 and PLEKHA2. The PDZ domain 13 binds SYNGAP1. SIMILARITY: Contains 1 L27 domain. SIMILARITY: Contains 13 PDZ (DHR) domains. SEQUENCE CAUTION: Sequence=AAC61870.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAC05409.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE06123.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH71900.1; Type=Erroneous gene model prediction; Sequence=CAI40490.1; Type=Erroneous gene model prediction; Sequence=CAI40491.1; Type=Erroneous gene model prediction; Sequence=CAI40492.1; Type=Erroneous gene model prediction; Sequence=CAI40494.1; Type=Erroneous gene model prediction; Sequence=CAI40495.1; Type=Erroneous gene model prediction; Sequence=CAI41236.1; Type=Erroneous gene model prediction; Sequence=CAI41237.1; Type=Erroneous gene model prediction; Sequence=CAI41238.1; Type=Erroneous gene model prediction; Sequence=CAI41240.1; Type=Erroneous gene model prediction; Sequence=CAI56786.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75970
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
